WEBVTT - #1837 Ozempic: Magic or Madness - David Gillespie 0:00:00.600 --> 0:00:04.200 Tivy and cook, David Bryan K Patrick Gillespian. It's the 0:00:04.200 --> 0:00:07.440 bloody you project. It's jumbo up the front. Where else 0:00:07.480 --> 0:00:10.600 would I be? We'll start with the lady in the room, height. 0:00:10.360 --> 0:00:13.680 Tiv front and center. You never he stumbled over all 0:00:13.720 --> 0:00:15.320 of those middle names this time. 0:00:15.800 --> 0:00:17.680 Yeah, I don't know. I don't know. He's told me 0:00:17.720 --> 0:00:20.520 I forget. Do you remember now? Do you remember? 0:00:21.160 --> 0:00:24.959 I don't remember them my real one. No, I have 0:00:25.000 --> 0:00:28.000 a real middle name. I remember. It makes that's right. 0:00:28.240 --> 0:00:32.760 See look at Tiffany wow because it makes an embarrassing acronym. 0:00:33.159 --> 0:00:36.320 Yeah, Dad, I thought of that attic as it came 0:00:36.360 --> 0:00:39.600 out of your mouth. Tiff Have you been cookie? How's 0:00:39.680 --> 0:00:44.600 the piano career, the musical career has it taken off? 0:00:45.360 --> 0:00:50.320 It's it's volatile because I go from in a moment yeah, 0:00:50.360 --> 0:00:52.320 because you know, I'm like a little bit impatient and 0:00:52.360 --> 0:00:56.400 I'm like, all right, boring, next, got this mastered, And 0:00:56.440 --> 0:00:58.960 in the moment I'm onto something new, I get frustrated. 0:00:58.960 --> 0:01:03.040 I'm like, why is this doing even had? How could 0:01:03.040 --> 0:01:06.480 they make it make any less sense? Music and reading music? 0:01:07.000 --> 0:01:10.000 Really, I don't know that that's meant to be one 0:01:10.040 --> 0:01:14.679 of the emotional and or psychological outcomes of playing music. 0:01:14.760 --> 0:01:17.560 I feel like it's meant to do the opposite. 0:01:17.000 --> 0:01:20.360 For one, that's where I'm at my best. 0:01:20.880 --> 0:01:23.320 I don't know that you're meant to be competitive when 0:01:23.360 --> 0:01:24.760 you're learning the piano tip. 0:01:25.160 --> 0:01:27.040 I know, but that's how I do everything. 0:01:27.880 --> 0:01:28.600 How's that going? 0:01:29.640 --> 0:01:29.920 Well? 0:01:30.080 --> 0:01:34.319 Really it is it? Could I run you through a. 0:01:36.520 --> 0:01:39.959 Have I dropped in on a psychology session here or something? Ever? 0:01:40.920 --> 0:01:48.360 Sorry? Sorry coming from Australia's leading anti psychology advocate. How 0:01:48.400 --> 0:01:49.920 are you, sir? How's your day going? 0:01:50.240 --> 0:01:50.320 What? 0:01:50.400 --> 0:01:55.040 It's Wednesday? Arbo? What's going on up there? Did you 0:01:55.040 --> 0:01:56.640 go to work today? Did you put on a suit? 0:01:57.920 --> 0:01:59.520 I did go to work. I didn't put on a 0:01:59.560 --> 0:02:02.680 suit because I didn't leave my office to go to work. 0:02:02.760 --> 0:02:04.840 But yeah, I did some work. 0:02:05.320 --> 0:02:07.240 Like an absolute grown up. Well, you wrote a good 0:02:07.320 --> 0:02:08.880 article that I don't know when you write it, but 0:02:08.919 --> 0:02:09.280 it went. 0:02:09.240 --> 0:02:12.519 Up today on finish it this morning. Yes, it's been 0:02:12.720 --> 0:02:14.280 in progress all week. 0:02:15.200 --> 0:02:19.440 So it's on substack everyone. Doctor Gillespie, as many of 0:02:19.440 --> 0:02:23.160 our listeners call you, Doctor Gillespie, who, just to be clear, 0:02:23.200 --> 0:02:28.240 isn't a doctor but could be could be. Doctor Gillespie 0:02:28.360 --> 0:02:33.919 has written an article silencing the food noise, and it's 0:02:34.080 --> 0:02:40.359 basically the once upon a time of ozeenpic. So it's 0:02:40.520 --> 0:02:46.160 now just so it's a g LP one what do 0:02:46.200 --> 0:02:46.720 they call it? 0:02:46.760 --> 0:02:51.720 And yes, yeah, yeah, agonist. 0:02:51.440 --> 0:02:56.400 So it's it's intended purpose Originally, I think I have 0:02:56.480 --> 0:02:58.680 not read the article. I should have. I apologize, but 0:02:58.720 --> 0:03:03.920 it's lower blood sugar. Was that its original intent? In fact, 0:03:03.919 --> 0:03:06.920 why don't you just tell us the story? You should 0:03:07.000 --> 0:03:10.640 read these articles. You know, it's a place I normally do. 0:03:10.720 --> 0:03:15.440 I had a corporate gig, Thesavo, and so I apologize. 0:03:16.120 --> 0:03:18.600 Okay. So it sort of started in the seventies when 0:03:18.639 --> 0:03:23.480 they were first started fiddling around with insulin and its 0:03:23.520 --> 0:03:31.320 counterpart of glucagon. Sorry, not glucagen. It's the They were 0:03:31.320 --> 0:03:35.600 doing it because a brand new disease was starting to occur, 0:03:35.840 --> 0:03:38.760 called type two diabetes. And it might seem odd to 0:03:38.800 --> 0:03:41.400 people today to think of type two diabetes as being 0:03:41.520 --> 0:03:45.360 a brand new disease, but it is. It really really 0:03:45.440 --> 0:03:48.440 wasn't a problem before the early nineteen eighties when we 0:03:49.000 --> 0:03:54.600 started taking health advice from the government and it so 0:03:54.680 --> 0:03:58.240 scientists were tooling around with some of the hormones which 0:03:58.280 --> 0:04:05.520 they knew were in this most particularly insulin. And you know, 0:04:05.600 --> 0:04:09.440 insulin's main job is to move glucose out of the 0:04:09.440 --> 0:04:14.440 bloodstream and into cells that need it. So you know, 0:04:14.920 --> 0:04:17.760 if muscles need energy, then they put receptors up to 0:04:17.760 --> 0:04:21.400 their cell surface, and insulin comes along and unlocks the 0:04:21.480 --> 0:04:24.799 receptor to allow the glucose to enter. Glucose just can't 0:04:24.800 --> 0:04:27.560 really nearly enter any cell in the body. It needs 0:04:27.640 --> 0:04:31.640 insulin to do it. And so insulin is produced in 0:04:31.720 --> 0:04:36.760 response to us eating stuff, and that raises our blood 0:04:36.800 --> 0:04:41.039 sugar level, which then causes insulin to be released, and 0:04:41.080 --> 0:04:44.720 then the insulin helps remove the glucose from the bloodstream. 0:04:45.120 --> 0:04:49.919 But you don't want to overshoot, because you know, you 0:04:49.920 --> 0:04:52.359 don't want all that insulin in your bloodstream running around 0:04:52.480 --> 0:04:56.240 releasing all the glucose out, and then you've got no 0:04:56.240 --> 0:04:59.279 glucose left in your bloodstream and you're dropped dead. So 0:04:59.600 --> 0:05:03.880 we have a counterpart to that called gluckagon, which is 0:05:03.920 --> 0:05:09.000 sort of anti insulin, if you like. And so when 0:05:09.160 --> 0:05:13.320 blood sugar levels start to go too low, either because 0:05:13.360 --> 0:05:16.360 you haven't eaten for a while or you've been exercising 0:05:16.480 --> 0:05:19.640 like a nutbag, then your body needs to bring those 0:05:19.720 --> 0:05:23.719 levels back up again, otherwise your brain will stop working 0:05:23.960 --> 0:05:30.680 and other important organs will probably too. And the glugagon 0:05:30.880 --> 0:05:36.480 travels to the liver and instructs the liver to release 0:05:36.600 --> 0:05:39.599 some sugar back into the bloodstream, so bring the sugar 0:05:39.600 --> 0:05:41.960 back up again. So that's what they knew in the 0:05:42.040 --> 0:05:48.880 nineteen seventies, and they, looking at that, thought, oh, maybe 0:05:48.920 --> 0:05:52.600 if we get to fiddle around with these hormones a bit, 0:05:53.880 --> 0:05:56.840 maybe we'll be able to do something about type two diabetes. 0:05:57.040 --> 0:06:02.680 Because type two diabetes is where you essentially have, you know, 0:06:02.839 --> 0:06:06.760 the blood shower is too high, and the body becomes 0:06:06.800 --> 0:06:10.800 effectively insulin resistant, that is, it's no longer listening to 0:06:10.880 --> 0:06:14.800 the signal from insulin telling cells to absorb the glucose 0:06:14.839 --> 0:06:19.240 out of the bloodstream, and having persistently glucose can start 0:06:19.240 --> 0:06:22.880 to do real damage. So they thought, oh, well, what 0:06:22.920 --> 0:06:25.000 if we fiddle around with the glucagon bit of that 0:06:25.240 --> 0:06:28.599 and see if we can, you know, fix that problem 0:06:28.640 --> 0:06:33.000 with a bit of messing about. They weren't terribly successful 0:06:33.080 --> 0:06:39.080 doing that, but they did happen across some other substances 0:06:40.360 --> 0:06:45.080 that were seemed to be part of the equation. They 0:06:45.080 --> 0:06:47.360 weren't quite sure what they did, but they did notice 0:06:47.400 --> 0:06:50.080 that one of them, in particular, one called GLP one 0:06:50.680 --> 0:06:57.080 or glucagon like peptide one, did an interesting thing. It 0:06:57.160 --> 0:06:59.800 seemed to be released around the same time as glucagon, 0:07:00.320 --> 0:07:08.080 and what it did was not only suppress appetite seemingly 0:07:08.240 --> 0:07:12.120 by sending a signal directly to the brain to tell 0:07:12.200 --> 0:07:16.680 us to stop eating, but it also made us feel 0:07:16.800 --> 0:07:21.800 physically full even if we weren't, so it essentially would 0:07:21.840 --> 0:07:25.680 shut us down. It was the biochemical equivalent of I 0:07:25.680 --> 0:07:27.440 don't know, wiring your mouth shut. 0:07:29.320 --> 0:07:29.480 You. 0:07:30.080 --> 0:07:32.280 If you were hit with this stuff, you couldn't eat anymore. 0:07:33.640 --> 0:07:37.760 And so they thought, oh, this is an interesting thing. 0:07:38.880 --> 0:07:42.520 Maybe if we gave people with type two diabetes some 0:07:42.560 --> 0:07:51.760 of this g l P one, then they's they'd eat less, 0:07:51.960 --> 0:07:54.680 but their blood sugar would be lower, and maybe that 0:07:54.720 --> 0:07:58.400 would help their diabetes. So they started doing some trials. 0:07:58.520 --> 0:08:03.040 It actually did, by the way. So the trouble with 0:08:03.160 --> 0:08:08.520 it was that it doesn't last very long in the body. 0:08:10.520 --> 0:08:14.559 So they gave it to people. It normalized their blood 0:08:14.600 --> 0:08:21.000 sugar levels, it made them feel full, but it was 0:08:21.400 --> 0:08:24.840 gone in minutes. It had a half life of minutes 0:08:24.880 --> 0:08:30.360 in the bloodstream. Mostly because we have a thing naturally 0:08:30.360 --> 0:08:33.440 occurring called DPP four, which I'm sure you're all terribly 0:08:33.440 --> 0:08:36.240 interested in, but it's kind of a molecular pac Man 0:08:36.280 --> 0:08:40.120 that goes around eliminating GLP one. Because this is all 0:08:40.160 --> 0:08:43.640 supposed to be being done in real time adjustments minute 0:08:43.640 --> 0:08:45.880 to minute in the human body. You know, you've got 0:08:45.880 --> 0:08:48.439 a bit too much blood sugar adjusted one way, got 0:08:48.480 --> 0:08:51.000 a little too little adjusted the other way, and so 0:08:51.040 --> 0:08:54.000 the body is really good at balancing those things, and 0:08:54.040 --> 0:08:57.520 so pumping us full of one of those hormones, which 0:08:57.559 --> 0:09:01.160 is what they were doing, didn't really work very well 0:09:01.200 --> 0:09:03.480 because the body said, ah, there's too much of that hormone. 0:09:03.520 --> 0:09:05.920 I'll just go and clean that up, and it did 0:09:05.960 --> 0:09:08.880 so within minutes. So the only real way it could 0:09:08.920 --> 0:09:11.800 be effective was to put someone on a drip where 0:09:11.840 --> 0:09:15.080 they were being continuously infused with it, and yes, then 0:09:15.120 --> 0:09:19.840 it did work. But that's not a particularly practicable, practical, 0:09:20.320 --> 0:09:24.200 or saleable way of managing type two diabetes. So this 0:09:24.240 --> 0:09:29.360 is where the drug companies got involved, In particular, Novo 0:09:30.040 --> 0:09:32.599 Nordisk always get their name wrong. Is Nova Nordisk I 0:09:32.679 --> 0:09:36.880 think it was who said let's have a look at 0:09:36.920 --> 0:09:39.400 this let's see if we can crack this nut about 0:09:39.559 --> 0:09:41.559 not having to have people tended to have dripped the 0:09:41.600 --> 0:09:45.360 whole time just to have this effect. And what they 0:09:45.360 --> 0:09:48.760 did is they managed to engineer a fatty coating to 0:09:49.080 --> 0:09:52.360 the GLT one that stopped it being destroyed by the 0:09:52.440 --> 0:09:56.679 DPP four and it would last thirteen hours rather than 0:09:57.200 --> 0:10:01.440 a minute. So suddenly you've got something that you could 0:10:01.520 --> 0:10:07.000 inject that will last a day effectively because the rest 0:10:07.000 --> 0:10:10.640 of the time you're asleep, And now you've got a 0:10:10.679 --> 0:10:14.760 marketable drug. So that's what they first came out with 0:10:15.400 --> 0:10:20.959 in the nineties I think it was, And from there 0:10:21.280 --> 0:10:26.280 the development took it further and said, hey, all right, 0:10:26.559 --> 0:10:30.160 we're making lots of money from that. What if we 0:10:30.160 --> 0:10:32.400 could do something that didn't have to be injected daily 0:10:32.600 --> 0:10:35.720 because even that's still a big ask, just say to 0:10:35.760 --> 0:10:38.240 someone with type to diabetes where you do have to 0:10:38.280 --> 0:10:42.320 inject this thing every day. And there was the other 0:10:42.360 --> 0:10:46.600 little problem, which is that, rather like GLP one, it 0:10:46.640 --> 0:10:49.960 also tended to make people extremely nauseous to the point 0:10:49.960 --> 0:10:53.960 of vomiting. Remembering that one of the effects of this thing, 0:10:54.080 --> 0:10:56.679 GLP one, is to make us feel full, and if 0:10:56.760 --> 0:11:00.320 you are on a continuous infusion of this. It is 0:11:00.480 --> 0:11:02.320 like you have just eaten the biggest meal of your 0:11:02.360 --> 0:11:05.280 life the entire time, and a lot of people's reaction 0:11:05.360 --> 0:11:09.400 to that is to vomit. So they feel so nauseous 0:11:09.440 --> 0:11:13.040 and so sick from being so full feeling that they vomit. 0:11:13.200 --> 0:11:15.760 So that's a bit of a nasty side effect as well, 0:11:15.960 --> 0:11:17.760 which limited its use. But it was a little bit 0:11:17.840 --> 0:11:19.600 less with the one that they made that had the 0:11:19.600 --> 0:11:23.920 fatty covering and that lasted thirteen hours. Wind forward a 0:11:23.920 --> 0:11:29.160 bit and they eventually cracked the problem, came up with 0:11:29.200 --> 0:11:32.160 a better version of it, one that would last an 0:11:32.280 --> 0:11:36.160 entire week before it was destroyed by the body. And 0:11:36.200 --> 0:11:40.920 that's what we call a zenpic now. And so suddenly 0:11:41.000 --> 0:11:44.880 they'd created all of this time while all this research 0:11:45.000 --> 0:11:47.080 was going on. Of course, diabetes begetting worse and worse 0:11:47.120 --> 0:11:49.719 and worse and worse at an exponential race. So we're 0:11:49.720 --> 0:11:52.400 gone from the nineteen eighties where it barely existed. They're 0:11:52.400 --> 0:11:54.200 doing all this research. By the time we get into 0:11:54.240 --> 0:11:59.080 the early noughties, then there's a market. Then there's a 0:11:59.120 --> 0:12:02.480 real market, and suddenly they've got a license to print money. 0:12:04.160 --> 0:12:07.760 Then they paid close attention to something they had noticed 0:12:07.800 --> 0:12:11.000 in some of the earlier studies, which is, not only 0:12:11.040 --> 0:12:15.559 did it seem to hold people's type two diabetes in check, 0:12:16.320 --> 0:12:18.720 they seem to lose a lot of weight while they 0:12:18.760 --> 0:12:23.280 were consuming it. And I guess that's not unexpected, you know, 0:12:23.480 --> 0:12:26.520 if you're having something that makes you feel full to 0:12:26.559 --> 0:12:29.560 the point where you want to throw up, you've got 0:12:29.600 --> 0:12:35.439 to eat less. So and then suddenly they found out 0:12:35.440 --> 0:12:37.880 that if you increase the dose a bit, you can 0:12:37.920 --> 0:12:40.120 really up that weight loss into the sort of ten 0:12:40.200 --> 0:12:44.199 to fifteen percent range for most people. And that's products 0:12:44.240 --> 0:12:46.840 like Wegovi, for example, which is a higher dose version, 0:12:47.840 --> 0:12:50.800 and it has approval to be sold as a weight 0:12:50.840 --> 0:12:53.480 loss medication, at least in the United States. 0:12:53.520 --> 0:12:54.360 So it. 0:12:56.000 --> 0:13:00.600 That's how we've gotten to today, which is first of all, 0:13:00.640 --> 0:13:03.000 just trying to find a way to do something about 0:13:03.000 --> 0:13:05.880 the hormones and fix type two diabetes, which was then 0:13:06.400 --> 0:13:09.359 not much of a problem but was clearly a growing problem. 0:13:09.880 --> 0:13:12.000 Now we've got an epidemic of type two diabetes and 0:13:12.040 --> 0:13:14.440 it's getting worse by the minute. And we've also got 0:13:14.480 --> 0:13:17.240 an epidemic of obesity, and it's getting worse by the minute. 0:13:17.360 --> 0:13:21.280 And this drug appears to address both of them, at 0:13:21.360 --> 0:13:24.440 least as long as you keep taking the drug. So 0:13:25.679 --> 0:13:28.120 it is unfortunately the case that as soon as you 0:13:28.240 --> 0:13:32.440 stop injecting this stuff, your body goes back to the 0:13:32.440 --> 0:13:33.040 way it was. 0:13:34.160 --> 0:13:37.400 But I just ask, and so is the weight loss 0:13:37.480 --> 0:13:41.640 mechanism is essentially just because people are consuming less calories, 0:13:41.679 --> 0:13:44.240 so still energy in and out is the I. 0:13:44.200 --> 0:13:48.480 Mean it's to do. It does have an effect on 0:13:48.559 --> 0:13:52.000 the brain's appetite control system a little as well, but 0:13:53.000 --> 0:13:56.720 it's a transient effect. The primary effect of it is 0:13:56.760 --> 0:13:59.800 that you feel so full that you couldn't eat anything anyway. 0:14:00.280 --> 0:14:04.000 So I guess it messes also with grellin and you know, 0:14:04.040 --> 0:14:06.720 the hunger hormone, and I think it's leptin, the society 0:14:06.800 --> 0:14:10.040 hormone or whatever like, so people. 0:14:09.920 --> 0:14:13.440 Part of that matrix of the hormones of appetite. 0:14:13.559 --> 0:14:17.440 Yes, and then so people, I mean, what unless I'm 0:14:17.480 --> 0:14:19.280 missing something and I don't know. So this is a 0:14:19.360 --> 0:14:22.720 legit question because I've done this is my first real 0:14:22.800 --> 0:14:25.560 lesson in ozen pic Like, I had a vague idea 0:14:25.840 --> 0:14:28.760 and I knew that it was originally designed for blood 0:14:28.760 --> 0:14:33.600 sugar regulation or flurering. You know, blood sugar blah blah blah. 0:14:33.680 --> 0:14:36.840 But and for type two diabetics, which is, as you said, 0:14:36.920 --> 0:14:42.640 is basically a new new condition. But like, ultimately the 0:14:42.680 --> 0:14:45.800 weight loss is still coming because or it's still a 0:14:45.800 --> 0:14:48.880 byproduct of people just consuming less food. 0:14:49.240 --> 0:14:54.640 Correct, Yeah, it's the it's the biochemical equivalent of stomach stapeling. 0:14:55.640 --> 0:14:57.280 So you know that. 0:14:58.840 --> 0:15:01.360 You could be just as a active by wiring people's 0:15:01.360 --> 0:15:07.760 mouth shut. It's the same essential principle, except you're doing 0:15:07.760 --> 0:15:15.080 it with drugs rather than physical impairments. So it's that's 0:15:15.120 --> 0:15:18.080 the principle of it, and it's effective for as long 0:15:18.360 --> 0:15:22.880 as you keep taking it or can tolerate it, remembering 0:15:22.920 --> 0:15:25.280 that the nausea thing is still there and some people 0:15:25.400 --> 0:15:27.600 can't tolerate that. Think. 0:15:27.920 --> 0:15:30.840 I think the lie though, is, oh, this drug makes 0:15:30.880 --> 0:15:35.520 you lose weight. Well, well, this drug makes you less hungry, 0:15:35.800 --> 0:15:38.080 and what makes you lose weight is the fact that 0:15:38.120 --> 0:15:43.560 you're fucking eating less, Like you're consuming less calories because 0:15:43.600 --> 0:15:47.760 you feel somewhere between full and sick and nauseous. And 0:15:47.800 --> 0:15:52.320 I'm reading the side effects here constipated, fatigued. Fuck. You know, 0:15:52.480 --> 0:15:56.960 it's like like the real reason that you're losing weight 0:15:57.200 --> 0:16:00.880 is just because you're reducing your calories, which and I 0:16:00.920 --> 0:16:03.680 know people will jump up and down, but you can 0:16:03.800 --> 0:16:05.560 kind of do that without these drugs. 0:16:06.600 --> 0:16:09.840 Yeah, And in fact, you can do it with weight 0:16:09.880 --> 0:16:11.880 loss shakes for example, for as long as you can 0:16:11.920 --> 0:16:15.200 tolerate that. I'm not believing, I'm not advocating for them. 0:16:15.600 --> 0:16:18.960 I'm just saying that they're the same essential principle, which 0:16:19.000 --> 0:16:23.800 is you just drastically reduce what you're consuming and then 0:16:23.880 --> 0:16:27.320 you will lose weight. There is another way to lose weight, 0:16:27.360 --> 0:16:29.880 which is stop consuming things which mess up your appetite 0:16:29.960 --> 0:16:35.840 control system, like fructose, and this doesn't help that at all. 0:16:36.320 --> 0:16:38.480 You can still you know, if the three grams of 0:16:38.480 --> 0:16:42.760 stuff that you can tolerate is fructose, then you're not 0:16:42.880 --> 0:16:46.240 changing anything about what you're consuming. You'll still lose weight 0:16:47.520 --> 0:16:50.720 because how much you can consume will be controlled. But 0:16:51.360 --> 0:16:53.880 the damage that's being done in there by the sugar 0:16:53.920 --> 0:16:57.120 a you know, which is you know, fatty, liver disease, 0:16:57.880 --> 0:17:03.120 kidney disease, hypertension, disease, all of those good things that 0:17:03.200 --> 0:17:07.560 sugar brings to us are all still there, but it's 0:17:07.640 --> 0:17:12.200 being masked by this drug which is hiding the obvious symptom, 0:17:12.400 --> 0:17:15.960 which is that you look fat or that you've got 0:17:16.000 --> 0:17:20.200 type two diabetes. So masking those symptoms is not very helpful. 0:17:21.920 --> 0:17:25.960 You're still doing the damage, you're just hiding it. And 0:17:26.880 --> 0:17:29.040 that's I guess the point of the article I wrote, 0:17:29.040 --> 0:17:36.840 which is to say, let's understand that this is like 0:17:36.920 --> 0:17:39.760 having a boat with a leak in it and then 0:17:39.880 --> 0:17:42.240 putting a pump in, and so the boat still keeps 0:17:42.280 --> 0:17:44.879 working for as long as the pump keeps working because 0:17:44.920 --> 0:17:46.920 it doesn't fill with water and sink to the bottom. 0:17:47.520 --> 0:17:50.720 But as soon as you turn the pump off, you've 0:17:50.720 --> 0:17:52.400 still got a boat with a leak in it. And 0:17:52.880 --> 0:17:55.359 that's what's going on here, only it's worse in that 0:17:55.400 --> 0:17:59.040 the pump is also hiding some other things that are occurring, 0:17:59.320 --> 0:18:03.239 which woul whether you were on this stuff or not, 0:18:03.400 --> 0:18:06.240 if you continue to consume the seed, oils or sugar 0:18:06.920 --> 0:18:10.520 that are causing the underlying metabolic conditions. Remembering that we're 0:18:10.560 --> 0:18:14.480 talking about a condition type two diabetes and obesity, both 0:18:14.480 --> 0:18:19.600 conditions that barely existed prior to nineteen eighty barely existed, 0:18:20.080 --> 0:18:24.439 and I know that for all of us living now, 0:18:24.880 --> 0:18:29.240 it seems like they've been there forever, but they really haven't. 0:18:29.840 --> 0:18:36.280 And the fact that that's the case stops us looking 0:18:36.359 --> 0:18:40.399 for the solution to the problem, stops us looking at 0:18:40.440 --> 0:18:43.800 the cause, stops us trying to repair the hole in 0:18:43.840 --> 0:18:47.560 the boat that's causing the leak, and diverts us to 0:18:47.720 --> 0:18:51.720 investing in better and better pumps to disguise it. Yeah. 0:18:52.200 --> 0:18:56.840 Yeah, And I think also it's worth noting that when 0:18:56.880 --> 0:19:00.159 people lose weight quickly, like a lot of weight the 0:19:00.240 --> 0:19:05.840 short time, generally what they're losing in order is water, muscle, 0:19:06.040 --> 0:19:10.600 and fat in that order. And then when they regain it, 0:19:10.840 --> 0:19:17.040 which is not inevitable but common, they regain water, fat, muscle. 0:19:17.480 --> 0:19:21.000 And so somebody who's gone through rapid weight loss, whatever 0:19:21.000 --> 0:19:24.280 the means of the rapid weight loss was, that you 0:19:24.320 --> 0:19:27.399 can find, for example, you know, somebody might start it. 0:19:27.520 --> 0:19:30.480 Let's just say one hundred kilos. They lose twenty kilos 0:19:30.520 --> 0:19:32.439 in eight weeks, which is two and a half kilos 0:19:32.440 --> 0:19:35.240 a week, which is too quick. Generally, they lose a 0:19:35.240 --> 0:19:38.240 lot of weight, and a fair percentage of that is 0:19:38.320 --> 0:19:41.840 lane tissue, is muscle, and then they regain the weight 0:19:42.600 --> 0:19:45.320 because the wedding's over, or the school reunion or the 0:19:45.359 --> 0:19:48.560 whatever is over and then they end up back at 0:19:48.560 --> 0:19:51.240 one hundred kilos, but now they've got a higher body 0:19:51.280 --> 0:19:54.600 fat percentage at the same weight because in this yo 0:19:54.720 --> 0:19:59.560 yoing cycle they've lost lane tissue and that as well. 0:20:00.040 --> 0:20:03.240 It's because you're not, once again not addressing the fundamental 0:20:03.280 --> 0:20:06.320 reason why you needed to lose weight in the first place, 0:20:07.640 --> 0:20:12.359 which is that something is malfunctioning in your environment that's 0:20:12.440 --> 0:20:15.320 causing you to eat more than you should. Something is 0:20:15.400 --> 0:20:20.159 interfering with your appetite control system. And believe it or not, 0:20:20.200 --> 0:20:24.560 we have a perfectly functional appetite control system. It's all 0:20:24.600 --> 0:20:28.720 controlled by hormones. It's all perfectly well regulated. As long 0:20:28.840 --> 0:20:32.520 as we don't mess with it, we will stop eating 0:20:32.520 --> 0:20:34.720 when we've had enough. We will know exactly how many 0:20:35.119 --> 0:20:39.560 calories is enough because our appetite control system will shut 0:20:39.640 --> 0:20:44.080 us down. The only time that doesn't happen is when 0:20:44.200 --> 0:20:48.240 we do something that breaks our appetite control system. So 0:20:50.040 --> 0:20:53.000 that's the fundamental thing, and it's a problem also even 0:20:53.200 --> 0:20:56.960 with most dietary prescriptions these days, whether it's will go 0:20:57.000 --> 0:21:00.000 over you or anything else, which is there's this fundamental 0:21:00.240 --> 0:21:03.680 thing assumption that what you've got to do to lose 0:21:03.720 --> 0:21:06.640 weight is get in there and manually start counting calories, 0:21:06.640 --> 0:21:11.680 which is idiotic because you don't do it when you're 0:21:11.840 --> 0:21:15.560 wanting to put on height. So when you're growing, you know, 0:21:16.280 --> 0:21:19.160 you didn't start out, you know, the fabular six foot 0:21:19.200 --> 0:21:23.159 five you are. You started out significantly smaller than that, 0:21:23.200 --> 0:21:27.600 and your body automatically allocated calories and resources to get 0:21:27.640 --> 0:21:30.600 you to the height that your hormones programmed you to be. 0:21:31.080 --> 0:21:34.240 But somehow when we and nobody would argue with me 0:21:34.320 --> 0:21:36.840 there if I said that to them. But for somehow, 0:21:36.880 --> 0:21:40.160 when we're talking about growing vertical, of growing horizontally rather 0:21:40.160 --> 0:21:44.399 than vertically, suddenly it willpower is required. It's like, in 0:21:44.520 --> 0:21:47.600 order to be six foot five, you had to will 0:21:47.640 --> 0:21:51.399 yourself to that height, and that's nonsense. You are that 0:21:51.520 --> 0:21:56.919 height because hormones made you that height, and the same 0:21:57.119 --> 0:22:01.760 goes for diet. There's this building in assumption that fault 0:22:01.880 --> 0:22:05.479 is involved, that in some way you are a weak person. 0:22:05.720 --> 0:22:08.679 If you're overweight that you are, you know you have 0:22:08.760 --> 0:22:13.159 some sort of moral fault, And bizarrely, it's a moral 0:22:13.160 --> 0:22:15.720 fault that's really only occurred in the population in the 0:22:15.760 --> 0:22:18.560 last fifty years. Prior to that, no one even gave 0:22:18.560 --> 0:22:21.600 it a moment's thought because prior to that, there was 0:22:21.680 --> 0:22:25.640 no significant corruption of our appetite control system, and our 0:22:25.680 --> 0:22:30.320 bodies did what they did, which is, they allowed us 0:22:30.359 --> 0:22:32.720 to eat when we needed to eat, and they stopped 0:22:32.800 --> 0:22:34.920 us eating when we'd had enough, and no one knew 0:22:34.960 --> 0:22:37.399 how to counter calorie and never needed to. 0:22:39.600 --> 0:22:42.119 Yeah. I saw a photo the other day of I 0:22:42.160 --> 0:22:44.959 don't know if you've seen that you too, I don't know. 0:22:45.040 --> 0:22:47.280 I don't know whether it was doctored, but it looked legit. 0:22:47.400 --> 0:22:51.080 It was like a photo of a bunch of ossies 0:22:51.119 --> 0:22:53.800 on the beach in nineteen sixty three. It was like 0:22:54.040 --> 0:22:54.960 hundreds of people. 0:22:55.400 --> 0:22:57.200 Yeah, I've seen the phone. 0:22:56.920 --> 0:22:58.760 Ever, Yeah, everyone in shape. 0:22:59.119 --> 0:23:02.840 Yep, you know, not necessarily in shape. 0:23:02.920 --> 0:23:05.000 I mean, well, what I mean is there was they 0:23:05.000 --> 0:23:08.919 won't overweight, no apparent obedity, is what I'm saying. 0:23:10.280 --> 0:23:12.679 And you don't need photos to see that. There's very 0:23:12.720 --> 0:23:18.040 good statistics on it. So the reality is that our 0:23:18.119 --> 0:23:24.040 current environment and our current population, this is the first 0:23:24.040 --> 0:23:27.360 time in human history that we've had any more than 0:23:27.400 --> 0:23:30.800 about ten percent of the human population overweight or obese. 0:23:33.640 --> 0:23:37.359 But we're up around seventy percent, and that's not ringing 0:23:37.400 --> 0:23:40.399 alarm bells, people looking at that and saying, oh, well, 0:23:40.480 --> 0:23:42.760 there must be some sort of moral turpitude, there must 0:23:42.800 --> 0:23:44.960 be some sort of fault, a lack of willpower. These 0:23:44.960 --> 0:23:49.320 are obviously weak willed individuals, And that's nonsense. It were 0:23:49.359 --> 0:23:52.320 this anything other than something that you could look down 0:23:52.400 --> 0:23:57.920 upon people about, were this growing an extra arm or whatever, 0:23:58.520 --> 0:24:01.320 we'd be trying to solve it. We'd actually be looking 0:24:01.320 --> 0:24:04.320 at the real causes and we'd be sorting it out. 0:24:05.000 --> 0:24:07.680 But for some reason, when it's something that you can 0:24:07.760 --> 0:24:12.800 sneer at people about and have a judgment about, suddenly, oh, 0:24:12.800 --> 0:24:14.639 well that's just because they're weak willed. 0:24:17.080 --> 0:24:23.280 Yeah. Interesting, Wow, it's that kind of you know, the 0:24:23.720 --> 0:24:27.399 inability to feel satisfied. You know that some people like 0:24:27.440 --> 0:24:30.760 where some people eat and it's like it's never enough, 0:24:31.320 --> 0:24:33.520 not because as you said, they're weak willed or they've 0:24:33.560 --> 0:24:39.040 got some psychological issue, but because that satiety they don't 0:24:39.080 --> 0:24:39.920 experience it. 0:24:40.320 --> 0:24:43.639 No, that doesn't because they have a malfunctioning appetite control system. 0:24:43.680 --> 0:24:47.520 And you can actually make this happen, like in animal experience, 0:24:47.560 --> 0:24:49.320 you can make it happen. You can disable the part 0:24:49.320 --> 0:24:55.120 of the brain that does control the appetite and they 0:24:55.119 --> 0:24:57.560 can't stop. Anyone who's ever owned a laborador knows this. 0:24:58.520 --> 0:25:03.399 You know, they're unable to be satisfied until they finished 0:25:03.400 --> 0:25:05.520 eating your socks and all the pebbles in the garden 0:25:05.640 --> 0:25:09.400