WEBVTT - #1916 The Sperm-Decapitating Parasite - Dr. Bill Sullivan

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<v Speaker 1>Doctor Bill, welcome back to the You Project, my friend.

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<v Speaker 2>How you doing, Craig, It's good to be back.

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<v Speaker 1>We always love chatting with you. We won't go too

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<v Speaker 1>far down the rabbit hole like we did a minute ago,

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<v Speaker 1>but we'll just I think I have to acknowledge that.

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<v Speaker 1>And of course everyone doctor Bill lives in the States.

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<v Speaker 1>It's it's we'll just go with It's interesting times over there.

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<v Speaker 2>Interesting is a good word, Yeah, well I would, I would,

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<v Speaker 2>I would use bizarre world or chaos, but interesting it

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<v Speaker 2>is a nice way to put it. Is there?

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<v Speaker 1>What is them? I mean, I'm sure there's Let's do

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<v Speaker 1>two minutes on this because I'm sure, especially my Australian

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<v Speaker 1>listeners wouldn't mind an insight from somebody who's living in

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<v Speaker 1>the middle of I don't know, I don't know what

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<v Speaker 1>I was going to say, chaos, but you're probably not

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<v Speaker 1>directly in the chaos, but kind of what's the most

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<v Speaker 1>when you say bizarro world, what's the most bizarre to

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<v Speaker 1>you just as a being in the middle or as

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<v Speaker 1>an observer of it, But what just kind of blows

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<v Speaker 1>your mind that's happening right now?

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<v Speaker 2>Well, I still can't get my head wrapped around the

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<v Speaker 2>fact that seventy million people in this country felt comfortable

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<v Speaker 2>putting a convicted felon who has a horrible track record

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<v Speaker 2>of fraud and you know, malevolence and just abject cruelty

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<v Speaker 2>into the office of the president, not to mention his

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<v Speaker 2>you know, colossally poor intellect and judgment that is demonstrable.

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<v Speaker 2>I mean, you can just investigate his history for this.

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<v Speaker 2>You know, he lives in a different universe and it's

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<v Speaker 2>not reality, it's not evidence based, and it's taking this

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<v Speaker 2>country right off a cliff to a point, a lawyer

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<v Speaker 2>who is utterly unqualified to lead you know, human health

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<v Speaker 2>services over here, which controls like our vaccine schedule and

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<v Speaker 2>a whole slew of other really critical health decisions, is

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<v Speaker 2>just beyond the point of absurdity. I feel like I'm

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<v Speaker 2>living in some kind of towilight zone. I mean, a

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<v Speaker 2>responsible leader just does not appoint these outrageously unqualified and

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<v Speaker 2>downright dangerous people into positions of power like that He's

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<v Speaker 2>going to get people killed.

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<v Speaker 1>Yeah, wow, it's from us. I mean, we just see.

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<v Speaker 1>I think every country in the world is somewhat obsessed

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<v Speaker 1>with America, and Australia is no different. I mean, if

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<v Speaker 1>we're not talking about us, we're talking about you as

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<v Speaker 1>he's probably everyone. But from the outside looking in, it's

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<v Speaker 1>I don't even know why, but even people in Australia

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<v Speaker 1>are like a bit scared. Some people a bit like

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<v Speaker 1>are the world's the world spinning out of control? And

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<v Speaker 1>you know, there's always been a bit of like background

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<v Speaker 1>stuff going on and a bit of this sense, and

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<v Speaker 1>you know, the outbreak here there, or a minor war

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<v Speaker 1>over here, not that there's such a thing as a

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<v Speaker 1>minor war, but you know what I mean is and

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<v Speaker 1>but right now it just seems like the volume has

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<v Speaker 1>been turned up on all the craziness like in the States,

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<v Speaker 1>but everywhere.

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<v Speaker 2>Yeah, it certainly seems that way, and I think that's

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<v Speaker 2>by design. Like I said, every day there's multiple things

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<v Speaker 2>happening that just don't make any sense or we're so outrageous,

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<v Speaker 2>you know, you can't believe someone just said that or

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<v Speaker 2>someone just did that, and there's no one saying anything

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<v Speaker 2>to like normalize or get people back to what used

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<v Speaker 2>to be normal. It just seems like we're going more

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<v Speaker 2>and more closer to the edge. And yeah, I share

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<v Speaker 2>your concern about that. It's not a comfortable feeling. So yeah,

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<v Speaker 2>it's it's pretty crazy times.

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<v Speaker 1>Yeah, yeah, it's a challenge. It's a challenge for everyone.

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<v Speaker 1>And it's even in Australia. It's not that, but it's.

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<v Speaker 1>Australia is an interesting place right now. You may or

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<v Speaker 1>may not know this, but we have the dearest real

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<v Speaker 1>estate in the world. Like it's it's like in Melbourne

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<v Speaker 1>where I live, to buy a property for the average

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<v Speaker 1>young person, the average young couple that are twenty five,

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<v Speaker 1>thirty thirty five, that just got married, whatever. For the

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<v Speaker 1>average people, they'll never own a home outright. But you

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<v Speaker 1>just can't, like a very in Melbourne. An average not

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<v Speaker 1>a good, not a you know, I don't mean not good,

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<v Speaker 1>but not nothing. Fancy you run in the mill three bedroom,

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<v Speaker 1>one or two bathroom, maybe thirty forty fifty year old

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<v Speaker 1>house is going to cost you one to one point

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<v Speaker 1>five million dollars.

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<v Speaker 2>Wow, that's just insane.

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<v Speaker 1>Is that crazy?

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<v Speaker 2>Is that causing a lot more people to rent instead

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<v Speaker 2>of buying a home?

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<v Speaker 1>Yeah, yeah, yeah, yeah, yeah, right.

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<v Speaker 2>Yeah, that's not good and that people can't save money

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<v Speaker 2>that way.

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<v Speaker 1>Where I live, which is not I mean, it's nice,

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<v Speaker 1>but it's not you know, there are some fancy areas.

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<v Speaker 1>But down the road from literally five hundred meters from me,

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<v Speaker 1>they've just built this new apartment complex. We'll get off

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<v Speaker 1>this in a minute, because we just sound like those

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<v Speaker 1>two old guys in the Muppets up in the bloody

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<v Speaker 1>you know stands.

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<v Speaker 2>But everybody loves those two craigs. Keeps done.

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<v Speaker 1>Yeah, well that's that's true. That's true. But just down

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<v Speaker 1>the road from me, they've built these apartments and they

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<v Speaker 1>start two bedroom apartments. There's two and three, but the

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<v Speaker 1>cheapest apartment you can buy is two bedroom, and it

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<v Speaker 1>says it kicks off at between one and three and

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<v Speaker 1>one point four million dollars. These are the starting prices

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<v Speaker 1>for a two bedroom apartment, which is you know, I

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<v Speaker 1>don't know, probably eight squares or something like that, ten

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<v Speaker 1>squares maybe, which is like a thousand square feet, you know,

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<v Speaker 1>give or take. I mean, yeah, it's crazy, and it's

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<v Speaker 1>I think, I don't know, it's an interesting time for

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<v Speaker 1>the specie. It's like it's an interesting time for humanity.

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<v Speaker 1>Like I'm wondering, one if we're going to be here

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<v Speaker 1>in a hundred years, I don't know, and two if

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<v Speaker 1>we are as a species here in one hundred years

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<v Speaker 1>what they're going to be saying about this time in history, you.

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<v Speaker 2>Know, right right, Well, yeah, I don't think it's going

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<v Speaker 2>to be anything good. I think there's going to be

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<v Speaker 2>a lot of what the hell were they thinking? Well,

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<v Speaker 2>you know, why were they being so stupid and ignoring

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<v Speaker 2>you know what scientists and experts are saying about the world,

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<v Speaker 2>you know, the dangers that are in front of us,

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<v Speaker 2>and then just totally dismissing experts for for charlatans and

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<v Speaker 2>you know, conspiracy theorists. It's just really difficult in this

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<v Speaker 2>modern day and age to see this kind of medieval

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<v Speaker 2>logic resurfacing. You know, it's just kind of it's downright scary,

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<v Speaker 2>and if we don't get a handle on it, it could

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<v Speaker 2>really spell disaster, a lot of suffering and death, very unnecessary.

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<v Speaker 2>What scares me the most is the increasing inequality, and

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<v Speaker 2>this is happening in all countries, where the very few

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<v Speaker 2>people who are just ridiculously wealthy are going to get

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<v Speaker 2>even wealthier at the expense of people who are trying

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<v Speaker 2>to climb out of poverty or just hold their own

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<v Speaker 2>in the middle class. I've studied quite a bit of

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<v Speaker 2>history on this topic. And every civilization just prior to

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<v Speaker 2>falling experience gross inequality that seemed to be one of

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<v Speaker 2>the key factors that was a telltale sign of societal collapse.

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<v Speaker 2>And it's getting worse every day. So we really need

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<v Speaker 2>to rein in this inequality that exists throughout the world

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<v Speaker 2>and getting rid of these billionaires. Millionaires should not exist

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<v Speaker 2>when we still have people who are starving in this world.

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<v Speaker 2>It's just such a gross, you know, distribution of the

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<v Speaker 2>world's resources, and it just cannot be sustained.

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<v Speaker 1>It must frustrate you as I mean, you're a proper scientist.

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<v Speaker 1>I'm not. I'm a summer pretend one. But it like

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<v Speaker 1>even for me on social media and people speaking out

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<v Speaker 1>about stuff, so I kind of inhabit more the psychology

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<v Speaker 1>or the more biology physiology. But when people come out

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<v Speaker 1>and they're saying essentially pop psychology bullshitty, you know, misleading

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<v Speaker 1>things about whatever about psychology or human behavior or the mind,

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<v Speaker 1>or they're trying to you know, they're talking about something significant,

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<v Speaker 1>like you know, trauma or grief or and you know,

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<v Speaker 1>some three step solution, and I roll my eyes. But

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<v Speaker 1>the truth is that a lot of people don't know

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<v Speaker 1>the difference between basically an Instagram post and science or

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<v Speaker 1>research or something that's you know, even people who so

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<v Speaker 1>my other degree, as you know, is XI science. But

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<v Speaker 1>people who will bring to me their supplements or their

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<v Speaker 1>you know, a food product and they'll, you know, because

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<v Speaker 1>it's got some tick or some star on the front,

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<v Speaker 1>this is good, right, And I'm like, no, let's turn

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<v Speaker 1>around and let's look at the back where the actual

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<v Speaker 1>information is. And I have to say to people, so,

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<v Speaker 1>what's on the front. This is not information. This is

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<v Speaker 1>a sales pitch to get you to pick it up

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<v Speaker 1>and buy it, right, That's not that's not information. The

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<v Speaker 1>information that they don't want you to see is around here.

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<v Speaker 1>I don't know what it is in the state it's

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<v Speaker 1>been in Australia. It's in the tiniest font that you

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<v Speaker 1>can't read in the bottom right hand or left hand corner.

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<v Speaker 1>That they try to make this thing as obscure as

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<v Speaker 1>possible because they don't want people to read it or

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<v Speaker 1>understand it or know what they're actually putting in their body.

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<v Speaker 1>I feel like that's going on a lot, and not

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<v Speaker 1>with just nutritional psychology or exercise, but across the board,

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<v Speaker 1>a version of that deception.

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<v Speaker 2>Yeah, and that's and that's that's really where it's at.

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<v Speaker 2>It's a deception. And people who market and you know,

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<v Speaker 2>profit from this stuff, they're the real villains. It's really

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<v Speaker 2>easy to blame people for not thinking or critically evaluating

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<v Speaker 2>things because we have a lot of trust in the society.

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<v Speaker 2>That's the way we're supposed to be functioning. But there's

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<v Speaker 2>a lot of cheaters, and one of the roles of

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<v Speaker 2>government is to neutralize these cheaters. So the real problem

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<v Speaker 2>comes back full circle to where we began this conversation, Craig,

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<v Speaker 2>is when you put cheaters into government, you really are

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<v Speaker 2>setting society up for an absolute disaster. And that's what

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<v Speaker 2>we've done in this country.

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<v Speaker 1>Yeah. Yeah, I don't know whether to make one maniac

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<v Speaker 1>steering this sheep.

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<v Speaker 2>Never is a good idea as a leader in politics,

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<v Speaker 2>in business, or in academia. It's just bad news any

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<v Speaker 2>which way you try to slice it.

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<v Speaker 1>M Well, speaking of bad news, Uh, speaking of bad news,

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<v Speaker 1>what about this article that you wrote, A common parasite

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<v Speaker 1>can decapitate human sperm with implications? Well, male fertility and

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<v Speaker 1>sperm count has been plumbing for decades, hasn't it, And

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<v Speaker 1>so give us a synopsis of the article that you wrote,

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<v Speaker 1>if you would doc.

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<v Speaker 2>So, yeah, before we I'm going to get right into that,

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<v Speaker 2>but I'm going to frame this as good news because

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<v Speaker 2>we've learned something here. You know, these studies are telling

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<v Speaker 2>us something important and there's things we can do to

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<v Speaker 2>prevent getting this infection. So we're going to spin this as, hey,

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<v Speaker 2>this is remarkable finding, disturbing, but remarkable, and now we

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<v Speaker 2>know what to do.

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<v Speaker 1>And that's why you're the that's why you're the professor,

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<v Speaker 1>and I'm the student.

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<v Speaker 2>That's well, you're getting your PhD sudents so you can

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<v Speaker 2>take me to school. But it also underscores you know,

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<v Speaker 2>you say, we went down a rabbit hole with our

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<v Speaker 2>little discussion, but it's really important and people in the

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<v Speaker 2>States and other places in the world need to realize

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<v Speaker 2>how important funding of basic science research is. It's what

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<v Speaker 2>produces results like the one we're going to talk about today,

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<v Speaker 2>so that society can take action to protect themselves from

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<v Speaker 2>potential danger. The administration we have in the States has

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<v Speaker 2>proposed it hasn't passed yet, but they propose to slash

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<v Speaker 2>biomedical research funding. This is the funding that allows me

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<v Speaker 2>to go to work and do experiments. They want to

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<v Speaker 2>cut it forty four percent so they can have more

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<v Speaker 2>money to feed these billionaires, you know, and this is

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<v Speaker 2>just devastating to everybody. So I can say that from

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<v Speaker 2>a very selfish angle. It's going to hurt me in

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<v Speaker 2>my lab. I might have to fire students or postdocs

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<v Speaker 2>as a result of this, Okay if it passes, and

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<v Speaker 2>that's just heartbreaking to me. But think about, you know,

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<v Speaker 2>the things that many scientific labs in the States are

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<v Speaker 2>going to produce over the next couple of years. Yeah,

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<v Speaker 2>you know, all sorts of wonderful things that could advance

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<v Speaker 2>treatments towards everything from Alzheimer's to zecravirus and everything in between.

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<v Speaker 2>And that's just not going to happen if the budget

0:13:38.360 --> 0:13:42.800
<v Speaker 2>gets slashed almost fifty percent. It's just insanity. And it's

0:13:42.880 --> 0:13:46.520
<v Speaker 2>even further insanity when you look at the money that

0:13:46.640 --> 0:13:52.160
<v Speaker 2>science gets. It actually produces almost a three percent profit

0:13:52.520 --> 0:13:55.200
<v Speaker 2>of economic activity in return. I mean, if you're going

0:13:55.200 --> 0:13:58.360
<v Speaker 2>to invest your government dollars in something, scientific research is

0:13:58.400 --> 0:14:03.160
<v Speaker 2>the most economically viable choice. So that's my soapbox. I'll

0:14:03.160 --> 0:14:04.040
<v Speaker 2>get off it for now.

0:14:04.200 --> 0:14:05.120
<v Speaker 1>No, I love it.

0:14:04.920 --> 0:14:09.520
<v Speaker 2>Well, might get into we'll get into the study. That

0:14:10.120 --> 0:14:13.800
<v Speaker 2>underscores how important it is that scientists are in their

0:14:13.880 --> 0:14:18.280
<v Speaker 2>labs and working on problems like this common parasite, which

0:14:18.559 --> 0:14:22.680
<v Speaker 2>we have talked about before. But for those of you

0:14:22.680 --> 0:14:26.480
<v Speaker 2>you know, who haven't heard of Tosoplasma GANDHII, this is

0:14:26.520 --> 0:14:30.040
<v Speaker 2>a parasite that's infected anywhere from thirty to fifty percent

0:14:30.080 --> 0:14:33.680
<v Speaker 2>of the world's population. That's a huge number of people.

0:14:33.720 --> 0:14:37.600
<v Speaker 2>We're talking billions now. Doesn't make people sick, you know,

0:14:37.680 --> 0:14:41.640
<v Speaker 2>unless you're severely immune compromised, but it stays with you

0:14:41.760 --> 0:14:45.680
<v Speaker 2>for life, gets into your brains as a cyst, gets

0:14:45.680 --> 0:14:48.440
<v Speaker 2>into your heart and scale to muscle. And what this

0:14:48.480 --> 0:14:50.960
<v Speaker 2>study that you alluded to, Craig, has just shown is

0:14:51.000 --> 0:14:57.000
<v Speaker 2>that it can get into male testicles and possibly be

0:14:57.320 --> 0:15:01.560
<v Speaker 2>affecting male fertility, which, as you said, over the past

0:15:01.800 --> 0:15:09.160
<v Speaker 2>decades has just nosedived and scientists have absolutely no idea why.

0:15:09.560 --> 0:15:12.760
<v Speaker 2>And to put that problem into perspective, here's one of

0:15:12.800 --> 0:15:18.080
<v Speaker 2>the statistics. Male infertility rates have increased nearly eighty percent

0:15:18.760 --> 0:15:23.720
<v Speaker 2>from nineteen ninety to twenty nineteen. Now that's crazy, and

0:15:23.760 --> 0:15:27.880
<v Speaker 2>you know that is something that should alarm everyone, and

0:15:27.960 --> 0:15:30.920
<v Speaker 2>it's something that scientists have really got to investigate more

0:15:30.960 --> 0:15:33.680
<v Speaker 2>rigorously because we have no idea what the hell's going on?

0:15:35.240 --> 0:15:39.880
<v Speaker 1>What about I know not much about this, well next

0:15:39.920 --> 0:15:43.760
<v Speaker 1>to nothing, But I heard somebody talking about a correlation

0:15:43.920 --> 0:15:49.720
<v Speaker 1>between plastics and thallites, you know, and all of the

0:15:49.880 --> 0:15:53.040
<v Speaker 1>leeching from plastic into foods and into water bottles and

0:15:53.120 --> 0:15:56.040
<v Speaker 1>into things that we cook in, and that in part

0:15:56.440 --> 0:16:02.359
<v Speaker 1>having an impact on you know, testosterone levels and fertility

0:16:02.400 --> 0:16:04.880
<v Speaker 1>and sperm count and all of those things. Is that

0:16:05.720 --> 0:16:06.320
<v Speaker 1>anything in.

0:16:06.280 --> 0:16:11.600
<v Speaker 2>That, Yeah, there's a lot of evidence to that effect.

0:16:12.520 --> 0:16:15.360
<v Speaker 2>What you're referring to are so called endocrine disruptors, and

0:16:15.400 --> 0:16:18.840
<v Speaker 2>these are chemicals that can get into our bodies and

0:16:19.000 --> 0:16:21.960
<v Speaker 2>they're so called forever chemicals, so once they get out

0:16:22.000 --> 0:16:25.800
<v Speaker 2>into the environment, they're very slow to break down, so

0:16:25.840 --> 0:16:29.000
<v Speaker 2>they're kind of out there for good. And you know,

0:16:29.040 --> 0:16:33.000
<v Speaker 2>they get into our tissues and disrupt our hormones, and

0:16:33.040 --> 0:16:37.040
<v Speaker 2>that can clearly have an effect on fertility, and in

0:16:37.080 --> 0:16:39.840
<v Speaker 2>some cases it seems to be heritable, you know, so

0:16:39.920 --> 0:16:43.040
<v Speaker 2>if you do have a child, the next generation seems

0:16:43.080 --> 0:16:46.960
<v Speaker 2>to be disadvantaged with respect to propagating the species. It's

0:16:47.320 --> 0:16:50.880
<v Speaker 2>pretty scary. But some of the other more common culprits

0:16:51.320 --> 0:16:56.320
<v Speaker 2>are obesity, poor diet, like malnutrition. You know, people eat

0:16:56.360 --> 0:16:58.800
<v Speaker 2>a lot of calories, but they're not necessarily getting the

0:16:58.920 --> 0:17:02.440
<v Speaker 2>nutrients they need. That can affect fertility for sure for

0:17:02.560 --> 0:17:05.800
<v Speaker 2>men and women. And then of course environmental toxins, which

0:17:05.840 --> 0:17:09.320
<v Speaker 2>includes the chemicals that you are talking about and a

0:17:09.320 --> 0:17:11.520
<v Speaker 2>whole slew of other ones. You know, there's so many

0:17:11.560 --> 0:17:16.320
<v Speaker 2>candidates out there that could be potentially hurting fertility. It's

0:17:16.359 --> 0:17:20.639
<v Speaker 2>really hard to, uh, you know, pinpoint which one or

0:17:20.840 --> 0:17:24.000
<v Speaker 2>which group is doing the most damage. And of course

0:17:24.040 --> 0:17:28.040
<v Speaker 2>it could be a combination of all these things. Microplastics

0:17:28.080 --> 0:17:31.600
<v Speaker 2>is coming into the picture now as another potential danger,

0:17:32.760 --> 0:17:38.280
<v Speaker 2>but what gets underappreciated are infectious diseases. They could also

0:17:38.359 --> 0:17:42.560
<v Speaker 2>be contributing to this problem, probably not to the same

0:17:42.680 --> 0:17:48.960
<v Speaker 2>extent as some environmental toxin or you know, bad health. Yes,

0:17:49.160 --> 0:17:51.400
<v Speaker 2>but I don't think it can be ignored, especially after

0:17:51.440 --> 0:17:53.879
<v Speaker 2>we go over some of the results you know of

0:17:53.920 --> 0:17:57.080
<v Speaker 2>this paper and studies that led up to it. But

0:17:57.200 --> 0:18:01.880
<v Speaker 2>infectious diseases like toxoplasma, which like microplastics, kind of get

0:18:01.880 --> 0:18:04.879
<v Speaker 2>in us and stay with us for life, but also

0:18:05.000 --> 0:18:08.400
<v Speaker 2>kind of rita and chlamydia. These are sexually transmitted diseases

0:18:08.800 --> 0:18:15.360
<v Speaker 2>that have a clear role in decreasing fertility or damaging fertility,

0:18:15.480 --> 0:18:20.160
<v Speaker 2>and they're just not emphasized enough part of the equation

0:18:21.240 --> 0:18:23.320
<v Speaker 2>and they just need to be talked about more.

0:18:24.920 --> 0:18:27.800
<v Speaker 1>Is before we jump into the specifics of your article.

0:18:29.480 --> 0:18:31.199
<v Speaker 1>If you've got a cat, everyone get rid of it.

0:18:34.080 --> 0:18:38.600
<v Speaker 2>We don't want to do that. I'll be here to

0:18:38.600 --> 0:18:42.400
<v Speaker 2>give you some guidelines on how to safely maintain a cat.

0:18:43.240 --> 0:18:45.960
<v Speaker 1>All right, what about important?

0:18:46.000 --> 0:18:47.960
<v Speaker 2>Why you said that? You know, we do have to

0:18:47.960 --> 0:18:49.160
<v Speaker 2>talk about why you said that.

0:18:49.440 --> 0:18:51.399
<v Speaker 1>We'll definitely talk about why I said that. But my

0:18:51.760 --> 0:18:55.200
<v Speaker 1>last one before I get out of your why is

0:18:55.200 --> 0:18:57.359
<v Speaker 1>is it would seem to me, I don't know if

0:18:57.400 --> 0:19:00.440
<v Speaker 1>we just talk about it more or there's a higher

0:19:00.520 --> 0:19:04.600
<v Speaker 1>incidence of people who don't seem to sleep well people

0:19:04.680 --> 0:19:07.600
<v Speaker 1>there seems to be maybe there's just more awareness, but

0:19:07.640 --> 0:19:10.760
<v Speaker 1>I think there's a high prevalence of anxiety and stress

0:19:10.800 --> 0:19:13.800
<v Speaker 1>and mental health issues. I would think that would be

0:19:14.560 --> 0:19:18.040
<v Speaker 1>that would have an impact on the endo crime system

0:19:18.080 --> 0:19:21.800
<v Speaker 1>as well, like poor sleep, inadequate sleep, you know, chronically

0:19:21.880 --> 0:19:25.880
<v Speaker 1>over time, so those things also would have a negative

0:19:25.920 --> 0:19:26.919
<v Speaker 1>correlation peraps.

0:19:29.160 --> 0:19:32.080
<v Speaker 2>Yeah, no question about it. I think they're all interrelated,

0:19:32.240 --> 0:19:34.679
<v Speaker 2>you know, to an extent. I mean, if you just

0:19:34.680 --> 0:19:37.600
<v Speaker 2>look at like poor diet and lack of exercise, that's

0:19:37.640 --> 0:19:40.440
<v Speaker 2>going to snowball into a lot of other risk factors

0:19:41.200 --> 0:19:45.600
<v Speaker 2>like obesity, some of the chemicals and ultraposit processed food.

0:19:46.359 --> 0:19:49.600
<v Speaker 2>And you know, without exercise, you don't you know where

0:19:49.640 --> 0:19:52.359
<v Speaker 2>the body out enough to get a good night sleep.

0:19:52.720 --> 0:19:55.400
<v Speaker 2>That can also be detrimental. So yeah, it all kind

0:19:55.440 --> 0:19:57.159
<v Speaker 2>of relates and snowballs together.

0:19:58.119 --> 0:20:01.399
<v Speaker 1>All right, So toxoplasma gone, y'all are the suspect in

0:20:01.440 --> 0:20:04.880
<v Speaker 1>the middle of all of this, all right? The focus

0:20:04.920 --> 0:20:05.840
<v Speaker 1>of today's.

0:20:05.520 --> 0:20:13.160
<v Speaker 2>Chat, a potentially new contributor to the male infertility problem

0:20:13.680 --> 0:20:16.280
<v Speaker 2>is what this new study that came out in April

0:20:16.720 --> 0:20:19.480
<v Speaker 2>is suggesting. And we do want to take it with

0:20:19.520 --> 0:20:23.800
<v Speaker 2>a grain of salt. You know, it's still very preliminary research,

0:20:24.240 --> 0:20:28.879
<v Speaker 2>but it's intriguing enough to warrant discussion and in my mind,

0:20:29.320 --> 0:20:33.879
<v Speaker 2>much larger serious studies to see if there's some truth

0:20:34.240 --> 0:20:40.639
<v Speaker 2>to toxoplasma possibly contributing to the male infertility problem. So

0:20:41.280 --> 0:20:44.160
<v Speaker 2>a little bit about toxoplasma first, just as a quick

0:20:44.240 --> 0:20:49.080
<v Speaker 2>review for people who don't listen to me being on

0:20:49.119 --> 0:20:51.240
<v Speaker 2>your podcast in the past, which they should go do.

0:20:52.640 --> 0:20:56.280
<v Speaker 2>Toxoplasma is transmitted in a number of ways, and that's

0:20:56.320 --> 0:21:00.159
<v Speaker 2>why it is so predominant throughout the human species. Like

0:21:00.160 --> 0:21:03.280
<v Speaker 2>we said, billions of people are infected because there's three

0:21:03.320 --> 0:21:07.800
<v Speaker 2>major routes of infection, the first of which is the cat.

0:21:08.359 --> 0:21:11.960
<v Speaker 2>So cats are the only organism where the parasite undergoes

0:21:11.960 --> 0:21:16.600
<v Speaker 2>its sexual stages. So when cats go to the bathroom,

0:21:16.600 --> 0:21:21.120
<v Speaker 2>they're releasing parasite eggs into the litter box, the sandbox,

0:21:21.359 --> 0:21:25.399
<v Speaker 2>or the environment, so they can contaminate the food and

0:21:25.480 --> 0:21:29.240
<v Speaker 2>water chain when they're infected with this parasite, and cat

0:21:29.280 --> 0:21:32.959
<v Speaker 2>owners can become infected if they don't promptly clean their

0:21:33.040 --> 0:21:39.320
<v Speaker 2>litter box and wash their hands very thoroughly afterwards. Kids

0:21:39.320 --> 0:21:41.680
<v Speaker 2>playing in the yard or sandbox can pick it up,

0:21:42.280 --> 0:21:45.119
<v Speaker 2>you know, people who garden can pick it up if

0:21:45.160 --> 0:21:48.680
<v Speaker 2>a cat's been in the garden unwashed. Fruits and vegetables

0:21:48.760 --> 0:21:52.359
<v Speaker 2>are a source of these parasite eggs, and these eggs,

0:21:52.400 --> 0:21:55.440
<v Speaker 2>once they're released into the environment are stable for one

0:21:55.440 --> 0:21:59.160
<v Speaker 2>to two years, so they don't go away quickly. They

0:21:59.200 --> 0:22:04.160
<v Speaker 2>also contaminate water, so filter feeders like shellfish, clams, and oysters.

0:22:04.600 --> 0:22:08.680
<v Speaker 2>They will trap these oasis into the tissues that people eat.

0:22:08.880 --> 0:22:12.840
<v Speaker 2>So if you eat raw shellfish, you're basically inoculating yourself

0:22:12.880 --> 0:22:18.160
<v Speaker 2>with this huge dose of toxoplasma. Eggs not a good idea.

0:22:18.800 --> 0:22:22.159
<v Speaker 2>So that's just from the cat. Any animal gets infected,

0:22:22.359 --> 0:22:26.920
<v Speaker 2>and like I said before, the parasite insists in brain, heart,

0:22:27.080 --> 0:22:31.320
<v Speaker 2>muscle tissue. So if we have raw or undercooked meat

0:22:31.600 --> 0:22:37.480
<v Speaker 2>almost any animal, pork, lamb, venison, steak, there's a chance

0:22:37.520 --> 0:22:40.400
<v Speaker 2>that toxoplasma could infect you that way if you don't

0:22:40.440 --> 0:22:46.320
<v Speaker 2>properly cook that animal. And then there's a really tragic

0:22:47.200 --> 0:22:51.600
<v Speaker 2>rout of transmission congenital transmission. This is mother to child.

0:22:51.760 --> 0:22:56.280
<v Speaker 2>So the reason why doctors tell people while they're pregnant

0:22:56.680 --> 0:23:00.800
<v Speaker 2>not to change the litter box is because of talk plasma.

0:23:01.640 --> 0:23:05.920
<v Speaker 2>If a woman becomes infected for the first time during

0:23:05.960 --> 0:23:11.040
<v Speaker 2>her pregnancy, that can lead to miscarriage or congenital birth defects,

0:23:11.400 --> 0:23:17.400
<v Speaker 2>and those can be quite devastating. Vision impairment, cognitive defects, defects,

0:23:17.400 --> 0:23:22.119
<v Speaker 2>and motor skills. It really runs the gamut. So three

0:23:22.440 --> 0:23:27.240
<v Speaker 2>major routes of transmission make toxoplasma a really common parasite.

0:23:27.320 --> 0:23:29.159
<v Speaker 2>And then on top of all of that, there's no

0:23:29.240 --> 0:23:31.760
<v Speaker 2>way to cure it. We can't get this parasite out

0:23:31.760 --> 0:23:35.320
<v Speaker 2>of our brains or out of our bodies. We can

0:23:35.440 --> 0:23:40.200
<v Speaker 2>control acute episodes of infection, so if the parasite reactivates

0:23:40.240 --> 0:23:43.880
<v Speaker 2>and starts causing brain damage or heart damage, there are

0:23:44.000 --> 0:23:47.639
<v Speaker 2>medications that people can take that will put the parasite

0:23:47.640 --> 0:23:52.240
<v Speaker 2>into remission. You know, those can be life saving drugs. Unfortunately, though,

0:23:52.280 --> 0:23:55.160
<v Speaker 2>they don't get rid of the parasite, they just put

0:23:55.160 --> 0:24:00.240
<v Speaker 2>it into remission. So when we're talking about this fertility problem,

0:24:00.400 --> 0:24:05.840
<v Speaker 2>you know, toxoplasma can get into men and one of

0:24:05.880 --> 0:24:09.919
<v Speaker 2>the areas that this parasite likes to go to, and

0:24:09.960 --> 0:24:12.800
<v Speaker 2>this has been confirmed not only in humans, but in

0:24:13.240 --> 0:24:17.440
<v Speaker 2>rodent models like mice and rats as well as a

0:24:17.480 --> 0:24:21.200
<v Speaker 2>few other species. This parasite goes to the testes within

0:24:21.280 --> 0:24:27.240
<v Speaker 2>two days of infection, so it's really remarkable to be

0:24:27.359 --> 0:24:31.520
<v Speaker 2>aware of that. So that's not good news. You know,

0:24:31.600 --> 0:24:34.800
<v Speaker 2>if you're a guy and have these parasites that just

0:24:34.920 --> 0:24:37.040
<v Speaker 2>kind of stay in your balls for the rest of

0:24:37.080 --> 0:24:40.719
<v Speaker 2>your life, you know, it's not a good situation. And

0:24:40.760 --> 0:24:46.480
<v Speaker 2>it raises the question if this parasite can invade male

0:24:46.560 --> 0:24:51.200
<v Speaker 2>reproductive organs. Does it have an effect on fertility? Could

0:24:51.200 --> 0:24:55.119
<v Speaker 2>it be contributing to this massive decline that we are

0:24:55.200 --> 0:25:00.159
<v Speaker 2>seeing in male infertility. So that's what this news that

0:25:00.240 --> 0:25:03.639
<v Speaker 2>he tried to address. But it was but it was

0:25:04.560 --> 0:25:06.800
<v Speaker 2>it didn't, you know, just come out of the ether

0:25:06.920 --> 0:25:09.359
<v Speaker 2>all of a sudden. There have been other studies done

0:25:10.040 --> 0:25:16.760
<v Speaker 2>suggestive that toxoplasma could have some effect on fertility. So

0:25:17.480 --> 0:25:19.600
<v Speaker 2>in one of the studies my own lab did, in

0:25:19.640 --> 0:25:24.400
<v Speaker 2>collaboration with a few of my buddies at Indiana University

0:25:24.400 --> 0:25:27.600
<v Speaker 2>School of Medicine, we found for the first time that

0:25:27.640 --> 0:25:32.080
<v Speaker 2>toxoplasma can insist in the prostate too, So you have

0:25:32.200 --> 0:25:36.320
<v Speaker 2>these parasite cysts sitting in the prostate and it actually

0:25:36.440 --> 0:25:43.359
<v Speaker 2>induces a sustained inflammatory response. So inflammation of the prostate

0:25:43.640 --> 0:25:49.040
<v Speaker 2>is one of the precursors to prostate cancer. So again

0:25:49.080 --> 0:25:52.560
<v Speaker 2>this is not good news either. I wanted to call

0:25:52.600 --> 0:25:56.919
<v Speaker 2>that paper great balls of Fire, but wouldn't let me

0:25:57.040 --> 0:26:00.840
<v Speaker 2>do it. It was, you know, this parasite's called inflammation

0:26:01.080 --> 0:26:04.760
<v Speaker 2>in the prostate. But you know, and that was in

0:26:04.840 --> 0:26:07.520
<v Speaker 2>just twenty seventeen, So these are really new discoveries. Craig

0:26:07.560 --> 0:26:09.720
<v Speaker 2>and a lot more work needs to be done, but

0:26:09.840 --> 0:26:12.240
<v Speaker 2>I think there's enough data in place right now that

0:26:12.320 --> 0:26:14.280
<v Speaker 2>says we've got to look at this problem a lot

0:26:14.280 --> 0:26:17.240
<v Speaker 2>more seriously and give it a lot more attention. We

0:26:17.280 --> 0:26:20.359
<v Speaker 2>certainly don't want to defund science up to fifty percent

0:26:20.480 --> 0:26:25.240
<v Speaker 2>at this point. But toxo has been found, you know,

0:26:25.400 --> 0:26:29.560
<v Speaker 2>in the semen of a variety of animals, including humans,

0:26:30.320 --> 0:26:34.000
<v Speaker 2>so you know it's in the ejaculate, which raises another

0:26:34.600 --> 0:26:41.159
<v Speaker 2>rather terrifying question. Is toxoplasma sexually transmitted? We don't have

0:26:41.240 --> 0:26:46.560
<v Speaker 2>an answer for that, but the possibility is there. Perhaps

0:26:46.720 --> 0:26:53.359
<v Speaker 2>during acute episodes they don't last too long, but during

0:26:53.440 --> 0:26:57.520
<v Speaker 2>that window there is a possibility with toxoplasma being present

0:26:57.560 --> 0:27:01.480
<v Speaker 2>in semen, it could be sexually admit it, you know,

0:27:01.560 --> 0:27:08.160
<v Speaker 2>another another reason to engage in safe sex. So yeah, yes, sorry,

0:27:08.160 --> 0:27:09.240
<v Speaker 2>go ahead and rambling.

0:27:08.880 --> 0:27:11.000
<v Speaker 1>Go on here, I'm just trying to Yeah, I'm not

0:27:11.080 --> 0:27:13.280
<v Speaker 1>terrified at all. Now, thanks for all of that. Back

0:27:13.320 --> 0:27:14.600
<v Speaker 1>in the therapy for harps.

0:27:15.080 --> 0:27:15.919
<v Speaker 2>That's what I'm here for.

0:27:16.480 --> 0:27:18.840
<v Speaker 1>Yeah, no good, just to come and terrorize me in

0:27:18.880 --> 0:27:22.120
<v Speaker 1>the masses. Okay, so a couple of things. I don't

0:27:22.119 --> 0:27:25.840
<v Speaker 1>even know what questions to ask, but here's one. So

0:27:25.920 --> 0:27:29.040
<v Speaker 1>thirty to fifty percent of people listening to their show

0:27:29.160 --> 0:27:37.640
<v Speaker 1>statistically have got toxoplasma gondie. So right, statistically, Yeah, yeah.

0:27:37.640 --> 0:27:40.720
<v Speaker 2>In Australia, I believe the numbers hover around twenty five

0:27:40.760 --> 0:27:41.520
<v Speaker 2>to thirty percent.

0:27:42.119 --> 0:27:45.439
<v Speaker 1>Okay, And I mean you may or may not know

0:27:45.480 --> 0:27:47.520
<v Speaker 1>the answer to this, but of the you know, if

0:27:47.560 --> 0:27:50.200
<v Speaker 1>we get ten people who have got it, how many

0:27:50.280 --> 0:27:54.879
<v Speaker 1>of them will ever show any symptoms or or be

0:27:55.800 --> 0:28:00.360
<v Speaker 1>you know, detrimentally affected, like there's some physical problem that

0:28:00.720 --> 0:28:01.720
<v Speaker 1>is because of that.

0:28:02.720 --> 0:28:04.800
<v Speaker 2>Oh yeah, no, that's a great question. And it depends

0:28:05.200 --> 0:28:09.199
<v Speaker 2>if they were congenitally infected, which means they acquired it

0:28:09.280 --> 0:28:13.800
<v Speaker 2>during birth. Yeah, those individuals tend to have problems throughout

0:28:13.800 --> 0:28:16.760
<v Speaker 2>the rest of their lives. The parasite reactivates from time

0:28:16.800 --> 0:28:19.480
<v Speaker 2>to time, and every time it does so, it does

0:28:19.520 --> 0:28:23.680
<v Speaker 2>brain damage, it does eye damage, It can inflame the heart.

0:28:24.240 --> 0:28:27.480
<v Speaker 2>Who knows, it might be damaging male reproductive organs as well,

0:28:27.760 --> 0:28:29.880
<v Speaker 2>based on what we've been learning very recently.

0:28:30.520 --> 0:28:33.960
<v Speaker 1>So and when people have episodes where things get in

0:28:34.600 --> 0:28:37.240
<v Speaker 1>like what's the treatment, Like what do they.

0:28:37.119 --> 0:28:42.320
<v Speaker 2>Do when you have an acute case of toxoplasmosis? There

0:28:42.360 --> 0:28:45.800
<v Speaker 2>are drugs called antifolates that the person can take and

0:28:45.840 --> 0:28:50.320
<v Speaker 2>they get the parasite under control fairly quickly, they'll stop

0:28:50.360 --> 0:28:56.320
<v Speaker 2>it from growing, and they'll retreat back into these insistent forms. Now, unfortunately,

0:28:56.400 --> 0:28:58.880
<v Speaker 2>the antifolates and no other drug that we know of

0:28:59.040 --> 0:29:03.360
<v Speaker 2>can get rid of the inc form. So that's the

0:29:03.400 --> 0:29:04.480
<v Speaker 2>obstacle to treatment.

0:29:05.600 --> 0:29:10.240
<v Speaker 1>I love this. So twenty twenty five study exposed human

0:29:10.280 --> 0:29:13.920
<v Speaker 1>sperm to T. Goondii in vitro. Twenty two point four

0:29:13.920 --> 0:29:18.800
<v Speaker 1>percent of sperm lose their heads, that is, and then

0:29:18.840 --> 0:29:23.440
<v Speaker 1>it says in brackets that is decapitated in just five minutes. Well,

0:29:23.520 --> 0:29:27.800
<v Speaker 1>do we have to bring the word decapitated? So that's

0:29:27.840 --> 0:29:32.080
<v Speaker 1>in vitro? Is that also representative in vivo? Like, is

0:29:32.080 --> 0:29:36.160
<v Speaker 1>that that happen you know, out of the lab as well?

0:29:36.240 --> 0:29:37.000
<v Speaker 1>Or we're not sure?

0:29:38.360 --> 0:29:41.840
<v Speaker 2>Yeah, that that's that's something that needs to be followed up.

0:29:41.840 --> 0:29:46.120
<v Speaker 2>But there is evidence that animals that are infected with

0:29:46.240 --> 0:29:51.880
<v Speaker 2>toxoplasma have deformed sperm. Wow, up until the new study

0:29:51.920 --> 0:29:54.720
<v Speaker 2>that you just mentioned, all of this was done in

0:29:54.760 --> 0:29:59.479
<v Speaker 2>other species. Okay, However, there were a couple studies that

0:29:59.520 --> 0:30:03.560
<v Speaker 2>were really interesting here that kind of led the group

0:30:04.240 --> 0:30:08.200
<v Speaker 2>to look at this question. There was a small two

0:30:08.280 --> 0:30:11.719
<v Speaker 2>thousand and five study that was done in China and

0:30:11.800 --> 0:30:15.680
<v Speaker 2>it found that sterile men are more likely to test

0:30:15.760 --> 0:30:22.320
<v Speaker 2>positive for toxoplasma than fertile men. So interesting correlation, but

0:30:22.400 --> 0:30:25.720
<v Speaker 2>a small study. There was another small study done in

0:30:25.760 --> 0:30:29.640
<v Speaker 2>twenty twenty one in Czechoslovakia. Just about one hundred and

0:30:29.680 --> 0:30:33.320
<v Speaker 2>fifty men or so, all of them were infected with

0:30:33.360 --> 0:30:35.959
<v Speaker 2>toxoplasma and they looked at their semen, they looked at

0:30:35.960 --> 0:30:40.760
<v Speaker 2>their sperm, and eighty six percent of them had defects

0:30:41.400 --> 0:30:45.520
<v Speaker 2>in their sperm. Now there's there's not a direct test there.

0:30:45.760 --> 0:30:48.560
<v Speaker 2>That's what the new study addresses. You know, the study

0:30:48.640 --> 0:30:52.760
<v Speaker 2>that was just done that that I just mentioned in

0:30:52.800 --> 0:30:58.120
<v Speaker 2>Czechoslovakia showed a correlation, didn't show that toxoplasma was responsible

0:30:58.560 --> 0:31:03.880
<v Speaker 2>for those defects in the sperm. So that's where this

0:31:03.960 --> 0:31:06.480
<v Speaker 2>new study came into play. And that's the new factor

0:31:06.480 --> 0:31:09.560
<v Speaker 2>that it contributed. It said, all right, well, let's just

0:31:09.600 --> 0:31:13.240
<v Speaker 2>cut to the chase. Let's take some toxoplasma parasites, mix

0:31:13.320 --> 0:31:16.800
<v Speaker 2>them with some live human sperm in a test tube

0:31:17.040 --> 0:31:19.560
<v Speaker 2>and see what happens. You know, maybe the parasites don't

0:31:19.560 --> 0:31:22.440
<v Speaker 2>do anything to the sperm. But that wasn't true. Like

0:31:22.480 --> 0:31:26.320
<v Speaker 2>you said, almost a quarter of the sperm lost their heads,

0:31:27.680 --> 0:31:30.320
<v Speaker 2>so they're dead. You know that sperm would be dead.

0:31:30.360 --> 0:31:33.840
<v Speaker 2>That's not a reversible feature. But if you go to

0:31:33.920 --> 0:31:37.600
<v Speaker 2>the article that I wrote, you'll see some really awful

0:31:37.680 --> 0:31:41.200
<v Speaker 2>pictures of what these parasites have done to the sperm.

0:31:41.480 --> 0:31:44.320
<v Speaker 2>You will see if the sperm manages to keep its

0:31:44.360 --> 0:31:48.240
<v Speaker 2>head okay, it'll usually have a hole in it where

0:31:48.240 --> 0:31:51.640
<v Speaker 2>the parasite tried to invade that sperm cell okay, and

0:31:51.640 --> 0:31:54.920
<v Speaker 2>then just left this gaping hole in the sperm head.

0:31:55.160 --> 0:31:56.240
<v Speaker 2>That can't be good.

0:31:57.040 --> 0:31:59.960
<v Speaker 1>The tails, I'm nice, sperm ex I'm nice.

0:32:01.000 --> 0:32:05.520
<v Speaker 2>Yeah, yeah, that can't be good. The tails of the sperm,

0:32:05.560 --> 0:32:08.520
<v Speaker 2>which are critical for the sperm being able to move

0:32:08.720 --> 0:32:11.520
<v Speaker 2>and get to the egg. They're all bent out of shape,

0:32:11.600 --> 0:32:14.360
<v Speaker 2>you know, kind of looping back around. They look like

0:32:14.400 --> 0:32:18.280
<v Speaker 2>they're almost snapped in places. The parasite's doing some really

0:32:18.320 --> 0:32:22.280
<v Speaker 2>serious damage to both the head and the tail of

0:32:22.320 --> 0:32:26.680
<v Speaker 2>these sperms. So it's not unreasonable to question, once you

0:32:26.760 --> 0:32:31.360
<v Speaker 2>see the devastation as parasite can inflict on sperm, that

0:32:31.520 --> 0:32:36.760
<v Speaker 2>it's going to lead to troubles in fertility. To what degree, Well,

0:32:36.920 --> 0:32:40.640
<v Speaker 2>that still remains to be answered. You know, we don't

0:32:40.760 --> 0:32:44.600
<v Speaker 2>know this. Sometimes maybe a misshape and sperm can still

0:32:44.640 --> 0:32:47.320
<v Speaker 2>get to the egg and it's not a problem. But

0:32:47.440 --> 0:32:51.240
<v Speaker 2>that is a question that needs to be more closely

0:32:51.320 --> 0:32:54.440
<v Speaker 2>looked at. And we also don't know, like you said,

0:32:54.480 --> 0:33:01.400
<v Speaker 2>in vivo in the body, can toxoplasma parasites gain access

0:33:01.520 --> 0:33:05.040
<v Speaker 2>to sperm cells to do the type of damage that

0:33:05.080 --> 0:33:09.200
<v Speaker 2>we saw in the test tube. That's really hard to address.

0:33:09.680 --> 0:33:13.040
<v Speaker 2>But we do know for a fact that toxoplasma can

0:33:13.840 --> 0:33:17.120
<v Speaker 2>invade the testes. It can get into the testicles, and

0:33:17.200 --> 0:33:20.000
<v Speaker 2>the new study showed evidence that it also gets into

0:33:20.520 --> 0:33:24.880
<v Speaker 2>a tube called the epididymous. This is where sperm cells

0:33:24.960 --> 0:33:30.560
<v Speaker 2>mature and get stored. So if toxoplasma can get access

0:33:30.680 --> 0:33:36.400
<v Speaker 2>to that tube, it could come in direct contact with sperm. Now,

0:33:37.440 --> 0:33:40.800
<v Speaker 2>something we want to get across so that people aren't

0:33:40.800 --> 0:33:45.360
<v Speaker 2>freaking out here, is that toxoplasma is not in its

0:33:45.440 --> 0:33:49.120
<v Speaker 2>active state, you know, for very long. You know, if

0:33:49.160 --> 0:33:53.840
<v Speaker 2>people become infected, you're usually you know, you usually can't

0:33:53.880 --> 0:33:55.720
<v Speaker 2>even tell, you don't get a lot of symptoms. But

0:33:55.760 --> 0:34:00.280
<v Speaker 2>the parasite develops into its cyst form very quickly, so

0:34:00.320 --> 0:34:04.120
<v Speaker 2>there's not free parasites floating around in your body all

0:34:04.160 --> 0:34:08.000
<v Speaker 2>the time. It would probably be limited to seven to

0:34:08.120 --> 0:34:11.960
<v Speaker 2>fourteen days maximum where you might have free parasites in

0:34:12.000 --> 0:34:16.600
<v Speaker 2>your body before they're all in the insisted stage. So

0:34:17.800 --> 0:34:20.239
<v Speaker 2>it's hard to believe that once they're in the late

0:34:20.280 --> 0:34:22.760
<v Speaker 2>and CIS stage that a lot of this sperm damage

0:34:22.760 --> 0:34:26.160
<v Speaker 2>could be happening. But like I said before, we did

0:34:26.239 --> 0:34:29.799
<v Speaker 2>show that at least in the prostate, even in its

0:34:29.800 --> 0:34:34.359
<v Speaker 2>insistent form, there's a sustained low level of inflammation in

0:34:34.400 --> 0:34:39.879
<v Speaker 2>these organs, and inflammation in male reproductive organs has been

0:34:40.000 --> 0:34:45.120
<v Speaker 2>linked to infertility as well, So that's another mechanism by

0:34:45.160 --> 0:34:50.560
<v Speaker 2>which toxoplasma could be adversely affecting fertility, not coming into

0:34:50.600 --> 0:34:56.680
<v Speaker 2>contact with sperm directly, but just by inducing inflammation down

0:34:56.719 --> 0:34:57.880
<v Speaker 2>in the gonad region.

0:35:00.680 --> 0:35:03.600
<v Speaker 1>Oh, this is just ruined my hall day. I don't know.

0:35:03.800 --> 0:35:05.960
<v Speaker 1>I don't know if I'm going to be able to think.

0:35:06.000 --> 0:35:08.000
<v Speaker 1>I have to kind of have a lie down and

0:35:08.320 --> 0:35:12.080
<v Speaker 1>kill the cat. No, I'm not everyone, I'm joking everyone.

0:35:12.080 --> 0:35:13.840
<v Speaker 1>I don't have a cat. If I did, I wouldn't

0:35:13.880 --> 0:35:19.280
<v Speaker 1>kill it. I wonder if there's like a a toxoplasma

0:35:19.480 --> 0:35:24.120
<v Speaker 1>dose threshold needed to harm sperm because it's got maybe

0:35:24.320 --> 0:35:27.080
<v Speaker 1>under a certain point it doesn't do damage. But I

0:35:27.120 --> 0:35:29.000
<v Speaker 1>don't know. I don't even know if that makes sense.

0:35:29.040 --> 0:35:32.600
<v Speaker 2>But that makes that makes perfect sense. That's one of

0:35:32.640 --> 0:35:35.000
<v Speaker 2>the variables that needs to be tested in a future

0:35:35.040 --> 0:35:39.520
<v Speaker 2>study because at the moment, you know, how do you

0:35:39.680 --> 0:35:42.720
<v Speaker 2>know that the number of parasites that you put into

0:35:42.719 --> 0:35:45.880
<v Speaker 2>that test tube with the sperm is anything close to

0:35:45.920 --> 0:35:49.840
<v Speaker 2>what actually happens in the body. That's an unanswered question.

0:35:50.000 --> 0:35:53.919
<v Speaker 2>We don't know that this is an artificial setup, right,

0:35:54.239 --> 0:35:57.760
<v Speaker 2>and it's just to assess. It's to just answer the question,

0:35:57.880 --> 0:36:03.160
<v Speaker 2>Ken toxoplasma damaged sperm, does it do it in the body? Maybe?

0:36:04.440 --> 0:36:10.920
<v Speaker 1>Okay, So managing catlet a personal hygiene, washing fruit and veggies, produce,

0:36:11.760 --> 0:36:18.200
<v Speaker 1>cooking meat, thoroughly avoiding raw shellfish, shout out to the

0:36:18.200 --> 0:36:24.319
<v Speaker 1>shellfish eaters, and obviously just good hygiene in general. Are

0:36:24.360 --> 0:36:28.360
<v Speaker 1>they that? Are they that kind of preventative pieces of advice?

0:36:29.480 --> 0:36:32.480
<v Speaker 2>Yeah, you said that just as well as I do.

0:36:32.719 --> 0:36:37.080
<v Speaker 2>You must have heard about toxoplasma before from somebody who

0:36:37.120 --> 0:36:37.480
<v Speaker 2>could that.

0:36:37.640 --> 0:36:40.800
<v Speaker 1>Or I might have notes on an article that you wrote.

0:36:40.840 --> 0:36:43.800
<v Speaker 1>So I will I will take none of your praise.

0:36:44.520 --> 0:36:48.480
<v Speaker 1>I just I just read what you wrote. And but

0:36:48.600 --> 0:36:52.920
<v Speaker 1>also I mean, and I know telling someone not to

0:36:52.960 --> 0:36:56.960
<v Speaker 1>worry doesn't stop anyone from worrying. But I mean, this

0:36:57.000 --> 0:37:01.120
<v Speaker 1>is something that's been around. It's prevalent anyway, you know,

0:37:01.320 --> 0:37:04.520
<v Speaker 1>half an hour earlier than right now, our audience, so

0:37:04.880 --> 0:37:07.880
<v Speaker 1>many of them didn't know about it. So it's nothing

0:37:07.920 --> 0:37:11.040
<v Speaker 1>to panic about, but just rather something to be aware of.

0:37:11.160 --> 0:37:15.400
<v Speaker 2>Right, Yeah, if you follow the simple steps that Craig

0:37:15.560 --> 0:37:19.800
<v Speaker 2>just outlined, your chances of getting toxoplasma go way down,

0:37:20.520 --> 0:37:23.200
<v Speaker 2>so you really don't have anything to worry about if

0:37:23.280 --> 0:37:26.440
<v Speaker 2>you take those simple precautions, and you know, it's not

0:37:26.560 --> 0:37:30.040
<v Speaker 2>much of a big ask, so you'll be fine. And

0:37:30.080 --> 0:37:33.040
<v Speaker 2>there's other reasons why you don't want toxoplasma. You know,

0:37:33.280 --> 0:37:37.040
<v Speaker 2>we already talked about congenital infection. But this parasite insists

0:37:37.040 --> 0:37:39.880
<v Speaker 2>in your brain, and there's evidence that it could cause

0:37:40.000 --> 0:37:44.840
<v Speaker 2>personality and behavioral changes. There's links to schizophrenia, links to

0:37:44.960 --> 0:37:47.960
<v Speaker 2>rage disorder. It's just a bad parasite to have in

0:37:48.000 --> 0:37:51.319
<v Speaker 2>your body, despite the fact that most people do. So

0:37:51.480 --> 0:37:55.680
<v Speaker 2>we are trying to do our best with educational campaigns

0:37:55.960 --> 0:37:59.319
<v Speaker 2>to minimize transmission of this parasite, and they do seem

0:37:59.320 --> 0:38:02.479
<v Speaker 2>to be working in a lot of countries around the world.

0:38:02.480 --> 0:38:05.920
<v Speaker 2>In the States, for example, toxoplasma zero prevalence used to

0:38:06.000 --> 0:38:09.759
<v Speaker 2>be twenty five percent in the nineties and the two thousands,

0:38:10.400 --> 0:38:13.600
<v Speaker 2>and the latest figures, now that more people know about it,

0:38:13.840 --> 0:38:17.120
<v Speaker 2>show in the United States toxoplasma zero prevalence is down

0:38:17.120 --> 0:38:21.120
<v Speaker 2>to about eleven percent, So you know these these educational

0:38:21.120 --> 0:38:25.000
<v Speaker 2>campaigns work. France used to have a zero prevalence of

0:38:25.280 --> 0:38:30.080
<v Speaker 2>ninety percent. Wow, isn't that crazy? Almost everybody in France

0:38:30.480 --> 0:38:33.440
<v Speaker 2>used to be infected with this parasite, but the latest

0:38:33.480 --> 0:38:36.960
<v Speaker 2>numbers show that's down to fifty percent. So we're making

0:38:37.000 --> 0:38:40.560
<v Speaker 2>a lot of progress, not with new cures, but just

0:38:40.800 --> 0:38:41.719
<v Speaker 2>with prevention.

0:38:43.080 --> 0:38:46.120
<v Speaker 1>Perfect Now you can find that article. It is a

0:38:46.200 --> 0:38:49.600
<v Speaker 1>really good article. It's on the Conversation and the website

0:38:49.600 --> 0:38:54.960
<v Speaker 1>address is all one word, the conversation dot com and

0:38:55.440 --> 0:38:58.360
<v Speaker 1>the name of the article is a common parasite that

0:38:58.600 --> 0:39:03.640
<v Speaker 1>can decapitite human sperm with implications for male fertility, and

0:39:03.680 --> 0:39:06.080
<v Speaker 1>that's written on May twenty eight, So go have a

0:39:06.120 --> 0:39:09.000
<v Speaker 1>look at that. And also for some of you, obviously

0:39:09.280 --> 0:39:13.600
<v Speaker 1>you might want to share this conversation perhaps with somebody

0:39:13.680 --> 0:39:17.040
<v Speaker 1>who you think might find it interesting, if not a

0:39:17.080 --> 0:39:19.920
<v Speaker 1>little terrifying, send it to them anyway. But also that

0:39:20.080 --> 0:39:24.760
<v Speaker 1>article is on the conversation dot com. We appreciate you, Doc,

0:39:24.880 --> 0:39:28.839
<v Speaker 1>It's always enlightening, a little bit scary, and a lot

0:39:28.880 --> 0:39:29.879
<v Speaker 1>of fun to chat with.

0:39:29.800 --> 0:39:33.279
<v Speaker 2>You well as always thanks for having me on, Craig

0:39:33.320 --> 0:39:34.440
<v Speaker 2>It's great to be here.

0:39:35.200 --> 0:39:37.400
<v Speaker 1>And before we go, if people want to find you,

0:39:37.440 --> 0:39:39.960
<v Speaker 1>follow you, connect with you, read more of your work

0:39:41.080 --> 0:39:42.480
<v Speaker 1>where and how can they do that?

0:39:43.200 --> 0:39:46.799
<v Speaker 2>Yeah, they can simply go to my website Wwwauthor Bill

0:39:46.880 --> 0:39:48.839
<v Speaker 2>Sullivan dot com.

0:39:48.840 --> 0:39:50.680
<v Speaker 1>Perfect. Thanks Doc, see you next time.