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Speaker 1: Doctor Nathan Bryan. Welcome to the podcast.

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Speaker 2: Hey Paul, great to see you. Thanks for having me on.

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Speaker 1: Where do we find you?

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Speaker 2: You know, I'm not sure how our paths crossed. I

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Speaker 2: have an agent that does a lot of my media.

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Speaker 1: No sor sorry, sorry mate, I meant we're in the world.

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Speaker 1: Are you physically.

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Speaker 2: My physically? Well, today I'm in Miami, but I'm originally

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Speaker 2: from Texas. Last week i was in Brazil today, as

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Speaker 2: I'm in Miami tomorrow min Orlando and then back in

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Speaker 2: Texas on Saturday.

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Speaker 1: Wow. And yeah, that that's a bit challenging, all of

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Speaker 1: that travel. And so you are. You are a pioneering

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Speaker 1: scientist and a health innovator and also a bit of

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Speaker 1: a biotech innovator. And give our listeners a little bit

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Speaker 1: of a tour, just a two minute tour of your

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Speaker 1: career so far, and then we'll then talk about what

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Speaker 1: you're really interested in at the minute.

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Speaker 2: Yeah sure. Now, I'm a small town Texas boy. I

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Speaker 2: went to the University of Texas at Austin, where I

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Speaker 2: got a degree in biochemistry. I then went to LSU

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Speaker 2: School of Medicine. I finished a PhD in molecular in

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Speaker 2: sitular physiology. I did additional training in Boston and Boston

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Speaker 2: University Medical Center and the Whitaker Cardiovascer Institute, and everything

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Speaker 2: I've done was related to the research around nitric oxide

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Speaker 2: and indigen signaling molecule. And then from Boston I was

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Speaker 2: offered a faculty position as a professor of molecular medicine

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Speaker 2: under ferredmad one of the gentlemen who shared the Nobel

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Speaker 2: Prize for the discovery of microcoside. And that was in

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Speaker 2: two thousand and five. I started my own independent research

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Speaker 2: career and we made a lot of discoveries and fought

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Speaker 2: a lot of patents, and you know, I went from

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Speaker 2: a you know, basic science researcher into a serial entrepreneur.

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Speaker 1: Very cool and look nitric oxide. So I know a

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Speaker 1: little bit about nitric oxide. I'm sure our listeners will

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Speaker 1: have heard of it. And the things that I know

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Speaker 1: about nitric oxide they're pretty thin on the ground. But

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Speaker 1: I know it's a ves of ves of dilator. I

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Speaker 1: know it's a signaling molecule. I know that beetroot juice

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Speaker 1: enhances it, and it's actually an effective sports supplement for

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Speaker 1: particularly for aerobic performance. I know that nasal breathing is

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Speaker 1: better than mouth breathing for nitric oxide. But that's about

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Speaker 1: the limit of it. So talk us through, just at

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Speaker 1: a high level, the discovery of it and why guys

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Speaker 1: won a Nobel Prize around it.

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Speaker 2: Yeah, well you get three out of four. Palm beats

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Speaker 2: in fact, aren't a great source of nitrocoxide. Oh, we'll

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Speaker 2: actually get into that. The other three are re absolutely correct.

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Speaker 2: But you know, nitrocoxide was discovered in the late seventies

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Speaker 2: and early eighties, and it was Fred Murad's discoveries that

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Speaker 2: drugs like nitroglycerin, and these drugs have been used for

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Speaker 2: one hundred years prior to the nineteen seventies for the

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Speaker 2: treatment of acute angelin in patients with obstructive cornery art disease,

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Speaker 2: but no one knew how they worked. Are they just

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Speaker 2: physicians used them because they were very effective at dilating

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Speaker 2: the cornery arteries and improving blood flow to the heart.

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Speaker 2: And Fred's in nineteen seventy seven paper discovered that these drugs,

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Speaker 2: called organic nitrates like nitroglycrin, are metabolized into a molecule

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Speaker 2: that activates a second messenger system that causes smooth muscle

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Speaker 2: relaxation in vasodilation. That was a very important discovery in

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Speaker 2: terms of pharmacology. And then in nineteen eighty Bob Firscott,

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Speaker 2: in a completely independent research program discovered that the endothelial

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Speaker 2: cells that line all the blood belsts without the body

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Speaker 2: produced again a molecule that activated the smooth muscle of

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Speaker 2: the blood vessels and caused the blood vessels to relax

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Speaker 2: and he termed this endothelium derived relaxing factor or EDERF,

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Speaker 2: so he knew it was released from the endothelium, he

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Speaker 2: knew what it did, but he did know what it was.

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Speaker 2: And then in nineteen eighty seven Loulignaro discovered that EDERF

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Speaker 2: is nitrocoxide, and other studies were showing that nitroglistern has

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Speaker 2: been tabilized into nitrocoxide gas and that was responsible for

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Speaker 2: vaso relaxation and vaso dilation. So the story was come

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Speaker 2: together that nitrocoxide is a signaling molecule in the cardiovascar system.

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Speaker 2: So whether you activate or stimulate endogenous nitrocoxide production, or

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Speaker 2: you give exogenous nitrocoxide active medication or product technology, it

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Speaker 2: all leads to smooth muscle relaxation. Vasodilation and then you

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Speaker 2: get improved bud flow and oxygen delivery to every organ,

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Speaker 2: tissue and sell on the body. That was the basis

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Speaker 2: for the Nobel price.

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Speaker 1: And is it purely working on endesthelial cells or is

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Speaker 1: it noigh known to work on other cells in the body,

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Speaker 1: And maybe give our listeners just a bit of a

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Speaker 1: view on the importance of the interaction with endothedeal cells

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Speaker 1: why that's so important for our cardiovascular health.

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Speaker 2: Well, first we have to understand that nitrocoxide's a gas, right,

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Speaker 2: It's a gas that's produced in the endothelial cells, and

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Speaker 2: once it's produced, it's gone in less than a second.

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Speaker 2: So thirty years ago was thought that nitrocoxete could only

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Speaker 2: act in the cell in which it was produced or

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Speaker 2: a neighboring cell. So when nitrocoxide's produced in the endothelo cells,

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Speaker 2: it regulates the expression of adhesion molecules on the end

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Speaker 2: of thenol cells themselves. So we call that an auurcrine function.

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Speaker 2: The nitrocoxide is working in the cell in which it

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Speaker 2: was produced. When we look at the vase of relaxation studies,

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Speaker 2: we call this a pariicrine effect because it's affecting neighboring cells,

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Speaker 2: and then there's endocrine effects similar to hormones. And so

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Speaker 2: it wasn't thought that nitrocoxide could be a hormone or

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Speaker 2: have endocrine effects because once it's produced, it's going in

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Speaker 2: less than a second. But my two thousand and seven

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Speaker 2: paper we published in the Procedings in National Academy of

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Speaker 2: Science shown demonstrated that nitrocoxide is in fact a hormone.

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Speaker 2: That nitrocoxide produced in one cell in the body can

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Speaker 2: be transported throughout the cardiovascosystem and effects cells distally. So

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Speaker 2: now nitrocoxide is considered a hormone, but it's produced in

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Speaker 2: the end of thilo cells. It's produced in our neurons.

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Speaker 2: Our immune cells upregulated nitrocoxide enzyme about four hours after

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Speaker 2: we see an infection, four hours after a wound response

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Speaker 2: or cytokine storm, and this is what we call inducible

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Speaker 2: nitrocoxide synthase. But it's naturally and constituently produced in the

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Speaker 2: end of thyl cells in the neurons, and then it's

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Speaker 2: upregulated in the immune cells, but then it's quickly turned

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Speaker 2: off its efforts killed the infection or elicited in an

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Speaker 2: acute inflammatory response.

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Speaker 1: Interesting, it's kind of a little bit like my muscle

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Speaker 1: myokines then, because when I first did my masters in

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Speaker 1: sports science, where we knew that myokines were molecules that

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Speaker 1: were released in muscles, and they were thought only to

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Speaker 1: have autocrime effects. I so, so for the listeners, we're

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Speaker 1: getting a bit giggy here, right, But that means has

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Speaker 1: an effect on the cell in which it's produced. And

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Speaker 1: then they discovered that that maocines also had parachrome effects, which,

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Speaker 1: as you said, means that they then affect neighboring cells.

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Speaker 1: But I think the game changer around myocins was that

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Speaker 1: they actually get out of circulated, get out of the

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Speaker 1: muscle into circulation, and then have effects on different organs.

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Speaker 1: So natric oxide apparently then has followed the same pathway

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Speaker 1: in terms of discoveries, because that's an absolute game changer

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Speaker 1: that then started people to view musculital muscle is an

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Speaker 1: endocrine organ and producing its own molecules that affect other organs.

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Speaker 1: So talk to us about a little bit about So

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Speaker 1: I knew it was important in endothelial cells. I obviously

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Speaker 1: didn't know about the neurons and the immune cells. So

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Speaker 1: so look, you touched on a little bit on the

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Speaker 1: in the immune cells, but just tell us what is it,

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Speaker 1: What role does it seem to be playing in our

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Speaker 1: immune cells, our immune system overall, and what roles are

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Speaker 1: playing in neurons, because that obviously then opens up the

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Speaker 1: whole conversation abright, brain health and neurodegenitive diseases.

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Speaker 2: For sure, Well, it's part of our nate immune system.

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Speaker 2: So the best example is, you know, the first was

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Speaker 2: in bacterial infections. So when we're exposed to bacterium, you know,

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Speaker 2: our immune cells have to become mobilized, right, and so

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Speaker 2: these immune cells go to the side of infection, and

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Speaker 2: again it takes four hours from these cido kinds to

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Speaker 2: induce the nuclear expression of these This inducible nitrocoxide syntha

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Speaker 2: synzyme found primarily in macrophages and neutrophils to some extent,

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Speaker 2: and monocytes, but it goes to the side of infection.

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Speaker 2: It produces a lot of nitrocoxide over a short period

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Speaker 2: of time. That nitric oxide is designed to iron, to

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Speaker 2: bind to the iron sulfur centers of bacteria, and it

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Speaker 2: completely shuts down bacterial respiration. Oh wow, that's how that's

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Speaker 2: how innate immune responds. It also occurs when we have

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Speaker 2: a wound, you know, a cut or something, same deal,

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Speaker 2: but we have to get those immune cells there and

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Speaker 2: then you create that acute inflammation and that's what we see,

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Speaker 2: you know, the heat, the color, the signs of inflammation.

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Speaker 2: That's mediated by nitroc oxide. So if we have a

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Speaker 2: robust immune response, we have inducible nitrocoxide synthest but more importantly,

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Speaker 2: we have a functional vasculture to dilate the blood vessels

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Speaker 2: to get the immune cells to the side of infection

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Speaker 2: or the side of injury. Then the immune cells can

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Speaker 2: do their job and then a lot of nitric oxide

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Speaker 2: short period of time down regulate it, and then it's over.

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Speaker 2: It's the acute inflammatory response to infections. And then furthermore,

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Speaker 2: it shuts down virus replication. You know, in two thousand

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Speaker 2: and five, it was reported that nitric oxide prevents the

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Speaker 2: chronavirus from replicating.

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Speaker 1: Oh wow, Then fast.

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Speaker 2: Forward fifteen years. You know, you know that people that

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Speaker 2: were getting sick and dying from COVID were the ones

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Speaker 2: who couldn't make nitrocoxide, which were the elderly prior heart

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Speaker 2: attack diabetes, hypertensive kiddy disease.

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Speaker 1: And that means, sorry, Nathan, by not being able to

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Speaker 1: make nitric oxide, your immune response to those infections basically

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Speaker 1: fell through the floor. Lam.

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Speaker 2: You become severely immuno compromised, and you become highly susceptible

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Speaker 2: to respiratory viruses including coronavirus.

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Speaker 1: Wow. And then let's talk about its rolling neurons and

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Speaker 1: and when was that first identified?

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Speaker 2: You know, that was the first pathway to be discovered

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Speaker 2: because NOS one is the neuronal nitrocoxide synthesis, the first

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Speaker 2: form that was discovered in clone. But it's produced in

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Speaker 2: our neurons and it's part of this you know, retrograde messaging.

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Speaker 2: So these it's it's produced in the post synaptic terminal

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Speaker 2: in a certain post and aptic clip and then it's

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Speaker 2: it diffuses back up and then controls the regulation of

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Speaker 2: things like you know, the glutamate, the r U MDA

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Speaker 2: receptors and in signaling through that. But it's involved in

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Speaker 2: long term memory potentiation. It's a neurotransmitter, but critically important

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Speaker 2: in nerve in neurotransmission.

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Speaker 1: Yeah, So just to maybe explain that to the lay

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Speaker 1: people again, are our neurons communicate in two ways. They

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Speaker 1: communicate electrically down the neurons and then from neurons to

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Speaker 1: neuron there's this gap called the synapse, and neurotransmitters are

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Speaker 1: used across the gap. That's why neurotransmitters are important. Right,

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Speaker 1: So if it's acting on the post synaptic neuron, it's

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Speaker 1: basically helping receive the signal from the other neuron, and

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Speaker 1: without that you don't get neurocommunication, right.

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Speaker 2: That's exactly right. So there has to be regulation in

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Speaker 2: cell signaling. And that's that's what cell signing is. It's

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Speaker 2: it's regulation of certain neurotransmitters or certain hormones or certain

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Speaker 2: other signaling molecules or second messenger systems, and you turn

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Speaker 2: them on and then there has to be an off switch.

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Speaker 2: And that requires cell to cell communication and adequate communication

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Speaker 2: not just between that you know, synaptic cleft between those terminals,

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Speaker 2: but communication from one neuron to the next. And so

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Speaker 2: the interesting thing about nitrocoxides is a gas, so once

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Speaker 2: it's produced, it can diffuse in three dimensions and it

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Speaker 2: goes back and regulates you know, upstream signal.

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Speaker 1: And then is it recycled.

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Speaker 2: It is so nitric oxide is oxidized to nitrite and nitride,

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Speaker 2: and then you know, we have nitrite reductant enzymes that

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Speaker 2: re reduce the reform nitrocoxide. But there's continuing metabolic shuttling.

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Speaker 2: We published on this in twenty eleven that once nitrocoxide

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Speaker 2: is produced, you get al citrolene as a byproduct. Right,

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Speaker 2: it's a metabolic byproduct. And the partially you recycle, which

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Speaker 2: is present in every cell in the body, converts the

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Speaker 2: citrilline back to arginine. So now argentine is available to

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Speaker 2: reproduce and make microcoxide through the nitrogoxide. So there's this

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Speaker 2: beautiful intramolecular shuttling of metabolites to recycle and to completely

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Speaker 2: reform microcoxite.

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Speaker 1: How freaking cod is the human body.

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Speaker 2: It's amazing, you know everything. The more I learned, the

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Speaker 2: more I'm intrigued and just impressed by how smart the

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Speaker 2: human body is. You know, it's certainly smarter than we

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Speaker 2: are come with medicine. Is we got to get out

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Speaker 2: of the way, let the body do its job.

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Speaker 1: Yeah, well exactly. And actually, as you because you as

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Speaker 1: you're talking about this, I'm thinking about because you know,

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Speaker 1: doing research and then you just discover a little bit,

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Speaker 1: and then you start to get excited about stuff and

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Speaker 1: you're like, why doesn't everybody know about this? Like what

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Speaker 1: tell us? What was this like when you were doing

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Speaker 1: your pH d in this area, working under guys who

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Speaker 1: had actually discovered nitric oxide, and then publishing other papers

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Speaker 1: like like that is for me, that is the new

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Speaker 1: Christopher Columbus exploreer type thing, right, this is where all

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Speaker 1: the discovery is left is inside our bodies. To just

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Speaker 1: talk us through, you know, your thought processes and levels

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Speaker 1: of excitement as you're starting to study this stuff.

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Speaker 2: Now, look, I had very good and really good mentors

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Speaker 2: that really gave me a different way to think than

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Speaker 2: most people. You know, research is to see what everyone

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Speaker 2: else has seen, but think what no one else has thought.

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Speaker 2: So that's been, you know, ingrained in my mind since

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Speaker 2: I was a student. But once we started developing analytical

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Speaker 2: techniques where we could detect nitrocoxide at levels produced in

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Speaker 2: biological systems, then that provided us with tools and really

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Speaker 2: very few labs in the world had, and so you know,

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Speaker 2: we were publishing, you know, in some years, ten to

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Speaker 2: twelve peer reviewed original research papers a year.

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Speaker 1: Wow.

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Speaker 2: And then when I when I started my own research career.

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Speaker 2: You know, for the first year, all I did I

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Speaker 2: didn't hire anybody. I didn't hire any student, any postdocs,

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Speaker 2: any technicians. I just went in the lab and I

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Speaker 2: started enabling patents because I knew that if I could,

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Speaker 2: I could find a way to make microcoxide, then I

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Speaker 2: could really have a way to change in the world.

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Speaker 2: And so I've been very fortunate and blessed to have

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Speaker 2: you know, several Eureka moments, you know, these aha moments

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Speaker 2: in the lab that for a minute I knew what

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Speaker 2: no one else in the world knew.

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Speaker 1: That's pretty cool, isn't it. Now?

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Speaker 2: That is cool? And look, that's I mean, that's what

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Speaker 2: drew me to science because there's nothing like the feeling

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Speaker 2: of discovery. And as you know, in science, you have

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Speaker 2: complete intellectual freedom. We can ask any question we want

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Speaker 2: and we can design an experiment to get an answer. Now,

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Speaker 2: it may not be the answer we're looking for, but

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Speaker 2: discoveries come from getting answers that you're not looking for,

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Speaker 2: the answers that are unexpected. And so that's what, you know,

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Speaker 2: that was my passion. And then you know, just documenting

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Speaker 2: it and filling out invention disclosure, submitting it to the

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Speaker 2: university so they can have their lawyers reviewed and then

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Speaker 2: submit patents on it. Because you know, we we know

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Speaker 2: how to do things that no one else in the

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Speaker 2: world had been able to do.

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Speaker 1: That's pretty exciting and I love that what your mentor

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Speaker 1: said that that it's about seeing what other people are seeing,

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Speaker 1: but but but thinking what other people aren't thinking that differently. Yeah, yeah,

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Speaker 1: that's that's that's the whole thing around it. And so

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Speaker 1: you talk about in your book, So you've written a

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Speaker 1: book on this obviously, so a bit of an expert

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Speaker 1: in it. Let's talk about nitric oxides and both produced

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Speaker 1: in the body. So you've mentioned that enzymatic and an

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Speaker 1: n dietary nitric oxide. So talk us through the relative

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Speaker 1: contributions and the interactions between those things.

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Speaker 2: Well, in physiology, there's enormous redundancy, right, so there's more

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Speaker 2: than one way is to get to these are compensatory systems.

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Speaker 2: Because the thought is, if this is an absolutely foundational

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Speaker 2: central molecule, which we all believe it is, then it

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Speaker 2: didn't make sense that nature devised a single pathway of production.

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Speaker 2: And that single pathway through this enzyme is a very

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Speaker 2: complex complicated five electron multi step oxidation reaction. It's energetically

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Speaker 2: and kinetically unfavorable. Right, So the thought was, there has

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Speaker 2: to be a different way to get this molecule to signal.

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Speaker 2: If it is as important as we believe it is

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Speaker 2: as a fundamental SIGNI molecule, then surely there's a different backup,

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Speaker 2: kind of compensatory, redundant pathway. And the answer came from

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Speaker 2: our diet and the bacterium. So the things like a

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Speaker 2: Japanese diet or a Mediterranean diet or a plant based diet,

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Speaker 2: the cardioprotective benefits of those dietary patterns can be explained

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Speaker 2: by nitrocoxide. These dietary patterns are incorporating foods with inorganic nitrate.

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Speaker 2: So this isn't organic nitrate like nitroglycerin. It's inorganic nitrate

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Speaker 2: in a three minus. It's part of the nitrogen cycle,

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Speaker 2: like when you add fertilizer to soil or you had compost,

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Speaker 2: it's nitrogen based and the cells the plants assimilate that

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Speaker 2: as nitrate, and then when we consume these plants, we're

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Speaker 2: consuming nitrate. Now, the interesting thing about this pathway is

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Speaker 2: nitrate is inert in humans. Humans do not have a

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Speaker 2: functional nitrate reductase enzyme. So, because we have the bacteria

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Speaker 2: that live in and on our body that have these

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Speaker 2: functional nitrate reductase enzymes, as long as we have the

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Speaker 2: right bacteria in our mouth, in our gut, now the

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Speaker 2: human body or the bacteria on and in the human

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Speaker 2: body can metabolize this into nitrocoxide metabolites. And then we

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Speaker 2: swallow our own saliva. And as long as we have

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Speaker 2: sufficient stomach acid production, we're getting nitrocoxide being produced in

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Speaker 2: the lumine of the stomach. And again, nitrocoxide produced anywhere

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Speaker 2: in the body, whether it's in the end of thenal cells,

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Speaker 2: whether it's in the lumine of the acidic stomach or

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Speaker 2: in the gut, it has systemic effects and it's a

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Speaker 2: hormone that's released the ghost systemic. So there's nitrocoxide production

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Speaker 2: sites that we can capture that hormone and then it

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Speaker 2: goes to stemic. But again this is dependent upon the

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Speaker 2: right diet. It's dependent upon the optimal microbiome, primarily on

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Speaker 2: the cryps of the tongue, and it's dependent upon stomach

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Speaker 2: acid production. And now when you start to look at

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Speaker 2: the contributions of a poor diet to chronic disease. Yes,

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Speaker 2: attributions of this biosis to chronic disease. Yes, contributions to

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Speaker 2: lack of stomach acid production and the preponderance of of

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Speaker 2: or the the you know, the use, the overuse and

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Speaker 2: misuse of ant acids. It's no wonder why the globe

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Speaker 2: is sick and pretty best, disease is the number one killer.

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Speaker 1: As you were talking about that, I'm thinking about antacids.

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Speaker 1: I'm also thinking about mousewash and things like that that

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Speaker 1: affect bacteria. And if we take a step back, isn't

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Speaker 1: it interesting that bacteria that and our microbes seem to

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Speaker 1: be the mediators between and the outside waters. Like I've

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Speaker 1: often talked about, we are not just an ecosystem, we

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Speaker 1: are a super ecosystem. And without all of these bacteria,

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Speaker 1: we just don't function, do we.

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Speaker 2: Now. Look, you know, one hundred years ago, we didn't

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Speaker 2: understand what a microbiome was. We thought all bacteria were

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Speaker 2: pathogenic and harmful, and we just had to kill all

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Speaker 2: the bacteria. And unfortunately, some of those same practices, especially

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Speaker 2: in dental medicine, trying to kill all the bacteria in

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Speaker 2: our mouth has survived one hundred years despite today knowing

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Speaker 2: that the human body is actually ten times more bacteria

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Speaker 2: than we are human cells. The microbiome, the bacteria that

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Speaker 2: live in and on our body outnumber our human cells

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Speaker 2: ten to one. Furthermore, the human genome is only coding

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Speaker 2: for about twenty three thousand gene products. The bacteria the

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Speaker 2: microbiome code for three million gene products and more than

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Speaker 2: one hundred times. So these bacteria that live in and

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Speaker 2: on our body. Look, we study the nitrocoxide producing effects

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Speaker 2: of this, but you know these bacteria are there. It's

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Speaker 2: a true symbiotic relationship. They're providing the human host essential

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Speaker 2: metabolites and providing metabolic machinery that humans don't have. And

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Speaker 2: so for killing these bacteria, we get human disease. I mean,

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Speaker 2: that is indisputable today in science and medicine.

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Speaker 1: So what's the implication? And I think people should just

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Speaker 1: let that settle in their heads and maybe even just

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Speaker 1: rewind it for a minute and listen to you say

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Speaker 1: that again, because it is just so critical how all

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Speaker 1: of these microbes are our mediators between us and our environment,

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Speaker 1: and that when we change these microbes, and a lot

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Speaker 1: of that is through our diet and other practices as

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Speaker 1: you say, medications, mouthwashes. We're actually changing how our super

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Speaker 1: ecosystem works. So what's the end that take home for

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Speaker 1: people here? Right, Let's start to get into that around diet.

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Speaker 1: So you mentioned around the diet, the Japanese diet, the

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Speaker 1: Mediterranean diet, vegetarian, so basically eating lots of fruits vegetables,

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Speaker 1: which we're always told this is another reason why we

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Speaker 1: need to do it right because of those nitrates in

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Speaker 1: the interaction. So maybe just expand a little bit first

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Speaker 1: on diet, and then maybe you can get into dental

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Speaker 1: health and other ways that we can optimize or at

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Speaker 1: least not sabotize the whole nitric oxide process.

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Speaker 2: Well, I think to follow up on the take home message.

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Speaker 2: The take home message from all of this is we

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Speaker 2: have to support a healthy microbiome and we cannot kill it,

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Speaker 2: we cannot destroy it. So we have to start doing

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Speaker 2: the things that support a healthy, diverse microbiome and stop

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Speaker 2: doing the things that are destroyed. So we can take

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Speaker 2: these one by one. Diet, eighty percent of the nitric

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Speaker 2: exposure that we get that humans get eighty percent comes

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Speaker 2: from green.

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Speaker 1: Leafy vegetables Wow.

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Speaker 2: Only five percent comes from you cured and processed meats

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Speaker 2: to which nitrite and NITRATEE are added. Then the other

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Speaker 2: ten to fifteen percent comes from swallowing our own saliva

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Speaker 2: because when we make nitric oxide, it's reduced to nitor,

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Speaker 2: it's oxidized to nitrite and nitrata, and then it's recirculated

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Speaker 2: in our saliva. So that's the sources of exposure. So

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Speaker 2: and diet is not just about what we eat, but

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Speaker 2: it's about what we don't eat. And what we're finding

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Speaker 2: is the most important thing in affecting the microbiome are

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Speaker 2: high glycemic index foods and sugar. Because when we consume sugar,

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Speaker 2: it completely changes the oral microbiome. It completely changes the

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Speaker 2: gut microbiome, It lowers the pH of our saliva, It

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Speaker 2: allows for these pathogenic, opportunistic bacterium and creates an environment

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Speaker 2: where the nonpathogenic commensals have a hard time surviving. So

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Speaker 2: elimination of sugar in anything that causes an increase in

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Speaker 2: blood sugar. You know, these continuous glucose monitors are available everywhere,

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Speaker 2: and I encourage everyone to just do an experiment. We're

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Speaker 2: one for a week. Figure out how your body responds

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Speaker 2: to the foods that you're eating. Anything that causes a

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Speaker 2: surgeon festing or in blood sugar, then don't do that

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Speaker 2: because it's going to cause chronic it's going to cause

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Speaker 2: damage to your to you're into female sales into your

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Speaker 2: microbiome and completely shut down microcoxset.

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Speaker 1: Production, sorry, Nathan. As well as that, then the impact

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Speaker 1: on insulin and when you have consistently high insulin, just

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Speaker 1: the the destruction that happens throughout the human body of that.

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Speaker 1: So that's two independent pathways by which eating a high

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Speaker 1: sugar diet and particularly the ultra processed foods that are around.

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Speaker 1: And are there any other compounds, Nathan, in all processed

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Speaker 1: foods other than the sugar and the high glycemic index

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Speaker 1: foods from eight processed carbohydrates. Is there any other thing

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Speaker 1: in ultra processed foods such as preservatives, flavor enhancers, or

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Speaker 1: emulsifiers that would compromise this pathway?

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Speaker 2: You know, we haven't really looked into that in terms

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Speaker 2: of we've done a lot of studies and looking doing

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Speaker 2: tongue scrapings and doing different interventions and seeing what's disrupting

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Speaker 2: the normal microbiome. I'm sure there are, you know, there's biofilms,

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Speaker 2: there's communities of bacteria, and then these emustifiers can destroy

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Speaker 2: that healthy microbiome in the biofilm. But you know, I'm

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Speaker 2: not aware of any controlled clinical studies looking at it.

431
00:25:41,200 --> 00:25:44,320
Speaker 2: The big takeaway is sugar. I mean, sugar is the enemy.

432
00:25:44,359 --> 00:25:48,240
Speaker 2: Sugars the toxins. You said, it's the hyperglascemia, hyperinstalnemia that

433
00:25:48,359 --> 00:25:52,000
Speaker 2: drives inflammation and that drives chronic disease. So if we

434
00:25:52,000 --> 00:25:55,120
Speaker 2: can address that and the other thing in insulince signaling

435
00:25:55,600 --> 00:25:58,600
Speaker 2: and glucose up take, we published in twenty eleven that

436
00:25:58,720 --> 00:26:03,520
Speaker 2: microcoxide is part of the signaling pathway. If the cell

437
00:26:03,600 --> 00:26:07,399
Speaker 2: cannot make nitrocoxide, then glute four does not get the

438
00:26:07,440 --> 00:26:09,600
Speaker 2: signal to go to the membrane and bring glucose into

439
00:26:09,600 --> 00:26:15,040
Speaker 2: the cell. So insulin resistance is a symptom of nitrocoxide deficiency.

440
00:26:16,320 --> 00:26:19,760
Speaker 2: That's you can't you can't transduce the insulin signal into

441
00:26:19,760 --> 00:26:22,679
Speaker 2: glutephoor and glucose uptake without microcoxide.

442
00:26:23,240 --> 00:26:25,720
Speaker 1: That's really interesting. I didn't know what impacted on glute

443
00:26:25,760 --> 00:26:30,680
Speaker 1: four because I remember Geez thirty years ago and being

444
00:26:30,680 --> 00:26:33,520
Speaker 1: taught in when I was doing my Master's nutrition and

445
00:26:33,520 --> 00:26:39,520
Speaker 1: particularly sports nutrition, that glute four was basically a back

446
00:26:39,640 --> 00:26:44,240
Speaker 1: door way to get glucose into the cell. That that

447
00:26:44,240 --> 00:26:47,840
Speaker 1: that affected insulin but was independent of it. And the

448
00:26:48,280 --> 00:26:53,199
Speaker 1: sort of analogy I had was like insulin, you know

449
00:26:53,280 --> 00:26:56,439
Speaker 1: that pathway coming into the cell is one way, but

450
00:26:56,680 --> 00:26:59,960
Speaker 1: glute for was like a bouncer on the back door

451
00:27:00,480 --> 00:27:03,399
Speaker 1: and letting you in the backway into the club, right,

452
00:27:03,480 --> 00:27:05,920
Speaker 1: and it was another way to get into the sale.

453
00:27:06,119 --> 00:27:10,520
Speaker 1: I didn't realize that nitric oxide impacted on glute four. Wow,

454
00:27:10,680 --> 00:27:11,480
Speaker 1: that's interesting.

455
00:27:11,800 --> 00:27:14,640
Speaker 2: Now there's two cysteine residues that are conserved throughout evolution

456
00:27:15,119 --> 00:27:18,880
Speaker 2: on glute four, and it's nitrocoxide that binds those cysteine

457
00:27:18,920 --> 00:27:22,199
Speaker 2: residues that leads to post translational modification, and it's the

458
00:27:22,240 --> 00:27:24,720
Speaker 2: signal that tells glue ford because glute for is typically

459
00:27:24,720 --> 00:27:28,800
Speaker 2: a cytosolic protein, and only in this postpran glucose spike

460
00:27:28,840 --> 00:27:31,240
Speaker 2: does glute four go to the membrane and clear that

461
00:27:31,240 --> 00:27:34,960
Speaker 2: glucose from the circulation. So without nitrocoxide, if you have

462
00:27:35,000 --> 00:27:38,520
Speaker 2: advanced by constellation in products and the sugar is stuck

463
00:27:38,560 --> 00:27:42,080
Speaker 2: to that enzyme, it can't make nitrocoxide, and that's what

464
00:27:42,119 --> 00:27:43,160
Speaker 2: we call insimilar resistance.

465
00:27:44,000 --> 00:27:46,480
Speaker 1: Oh right, So let me translate that from people because

466
00:27:46,480 --> 00:27:49,840
Speaker 1: people will be like, what language was he just talking?

467
00:27:49,960 --> 00:27:56,160
Speaker 1: Why didn't he just say that? So basically what you're

468
00:27:56,160 --> 00:27:59,119
Speaker 1: talking about. So when you ate, you get that insulin spike,

469
00:27:59,280 --> 00:28:04,359
Speaker 1: and nitric oxide plays a critical role in getting that

470
00:28:05,200 --> 00:28:08,040
Speaker 1: into the cell, getting that glucose into the cell. And

471
00:28:08,080 --> 00:28:11,720
Speaker 1: if it's not effective, then we keep using our insulin,

472
00:28:11,800 --> 00:28:16,960
Speaker 1: then we get insulin resistance and it just destroys all

473
00:28:17,040 --> 00:28:19,960
Speaker 1: of the organs in our body. Like high levels of

474
00:28:20,000 --> 00:28:23,800
Speaker 1: insulin is an absolute killer, as you said, drives inflammation,

475
00:28:23,960 --> 00:28:29,240
Speaker 1: which drives chronic disease. So nitric oxide is really important

476
00:28:29,280 --> 00:28:34,879
Speaker 1: in that absolutely critical step of disposing of blood glucose.

477
00:28:37,200 --> 00:28:41,240
Speaker 1: So let's talk about you mentioned the oral microbiome. All right,

478
00:28:42,040 --> 00:28:45,160
Speaker 1: let's talk a little bit about that and how do

479
00:28:45,240 --> 00:28:47,560
Speaker 1: we because a lot of people now, I think, know

480
00:28:47,640 --> 00:28:51,160
Speaker 1: about the gut microbiome and the importance of a healthy,

481
00:28:51,280 --> 00:28:56,840
Speaker 1: diverse gut microbiome, but digestion and particularly of carbohydrates, actually

482
00:28:56,840 --> 00:29:01,360
Speaker 1: starts in the mouth, and you mentioned that nitric oxide

483
00:29:01,640 --> 00:29:05,320
Speaker 1: and that that process actually starts in our mouth. The exogenist.

484
00:29:05,800 --> 00:29:10,760
Speaker 1: So talk us through the importance of this and what

485
00:29:10,800 --> 00:29:13,080
Speaker 1: are the take homes for people? What are the dos

486
00:29:13,120 --> 00:29:15,640
Speaker 1: and don'ts around your oral microbiome.

487
00:29:17,280 --> 00:29:20,000
Speaker 2: Well, I'll kind of explain this pathw because this goes

488
00:29:20,000 --> 00:29:22,320
Speaker 2: back to nineteen seventy eight when it was first discovered

489
00:29:22,360 --> 00:29:26,840
Speaker 2: that nitrade that we get from our diet is about

490
00:29:26,880 --> 00:29:31,400
Speaker 2: twenty five percent reabsorbed in the kidneys, and so the

491
00:29:31,440 --> 00:29:34,800
Speaker 2: body reabsorbs it, right, So we're filtered and then reabsorbed.

492
00:29:34,800 --> 00:29:37,200
Speaker 2: So the body is trying to conserve this molecule, but

493
00:29:37,240 --> 00:29:40,240
Speaker 2: initially it's concentrated in our salivary glanes and so the

494
00:29:40,360 --> 00:29:43,680
Speaker 2: nineteen seventies, it was scientists couldn't describe why the body

495
00:29:43,680 --> 00:29:47,480
Speaker 2: would intentionally concentrate nitride in our salbary lanes. Well, today

496
00:29:47,520 --> 00:29:50,120
Speaker 2: we understand that because ninety minutes after we consume a meal,

497
00:29:50,720 --> 00:29:53,920
Speaker 2: we start secreting that nitratee in our saliva and this

498
00:29:53,960 --> 00:29:57,800
Speaker 2: is acting as a prebiotic for these nitrate reducing bacteria.

499
00:29:57,840 --> 00:29:59,640
Speaker 2: So these are faculty of anaerobes that live on the

500
00:29:59,640 --> 00:30:01,560
Speaker 2: dorse part of the tongue, the back of the tongue,

501
00:30:02,000 --> 00:30:05,120
Speaker 2: deep in the crypts, and so they use this nitrogen

502
00:30:05,160 --> 00:30:07,600
Speaker 2: as an energy source, and they perform this two electron

503
00:30:07,640 --> 00:30:11,040
Speaker 2: reduction of nitrate to nitrite. So now our saliva is

504
00:30:11,120 --> 00:30:15,160
Speaker 2: enriched in nitrite. Then we swallow our saliva and we

505
00:30:15,240 --> 00:30:18,400
Speaker 2: have a stomach acid and we produce nitrocoxide in the

506
00:30:18,440 --> 00:30:20,800
Speaker 2: lumin of the stone. But all that's dependent upon the

507
00:30:20,880 --> 00:30:21,560
Speaker 2: right bacteria.

508
00:30:22,160 --> 00:30:26,880
Speaker 3: Wow, so we ate stuff, then there's there's a triggering

509
00:30:26,920 --> 00:30:30,320
Speaker 3: mechanism that goes right back up to the tongue that

510
00:30:30,560 --> 00:30:34,040
Speaker 3: then produces that did you say, nitrate or nitrite that

511
00:30:34,080 --> 00:30:36,680
Speaker 3: then goes down into the stomach to help digestion.

512
00:30:36,800 --> 00:30:41,400
Speaker 1: So that's that little circular thing whole stating. Wow, jeez,

513
00:30:41,400 --> 00:30:42,960
Speaker 1: that's fascinating, nod.

514
00:30:43,080 --> 00:30:48,080
Speaker 2: Look, and the nitrite that is in our saliva, it's antibacterial,

515
00:30:48,200 --> 00:30:53,040
Speaker 2: so it'll kill things like H. Pylori the old ah kill.

516
00:30:53,200 --> 00:30:55,680
Speaker 2: If you've got a little E. Coli, our botulism or

517
00:30:55,720 --> 00:30:59,080
Speaker 2: salmonella on your food and you have adequate nitrocoxide or

518
00:30:59,120 --> 00:31:02,720
Speaker 2: something tried in your saliva, it kills these bacteria in

519
00:31:02,760 --> 00:31:05,120
Speaker 2: the lumin of the stomach. And so to me is

520
00:31:05,120 --> 00:31:09,080
Speaker 2: about chemist and physiologists. The absolute worst thing that I

521
00:31:09,080 --> 00:31:12,800
Speaker 2: could ever imagine in disrupting normal human physiology is to

522
00:31:12,800 --> 00:31:16,920
Speaker 2: suppress stomach acid production. These drugs are used two hundred

523
00:31:16,920 --> 00:31:19,440
Speaker 2: million prescriptions in the US written every year and now

524
00:31:19,440 --> 00:31:20,600
Speaker 2: you don't even have that prescription.

525
00:31:21,120 --> 00:31:25,160
Speaker 1: Yeah, talk us through that, because these those drugs are

526
00:31:25,280 --> 00:31:29,400
Speaker 1: are going crazy in terms of their use. So tell

527
00:31:29,480 --> 00:31:33,680
Speaker 1: us why that's happening. And there's an obvious thing here

528
00:31:33,920 --> 00:31:39,040
Speaker 1: in terms of understanding what the root causes and what

529
00:31:39,080 --> 00:31:42,120
Speaker 1: we're doing, as we often do in medicine, is don't

530
00:31:42,160 --> 00:31:44,800
Speaker 1: address the root cause and we put a bandy it

531
00:31:44,840 --> 00:31:47,360
Speaker 1: over it, which ends up making things worse.

532
00:31:49,160 --> 00:31:52,520
Speaker 2: Well. Number one, reflux. So these drugs called the class

533
00:31:52,520 --> 00:31:54,480
Speaker 2: of drugs were talking about are called proton pump inhibit

534
00:31:56,040 --> 00:32:00,640
Speaker 2: the poloric cells from making hyperchloric acid. And so they're

535
00:32:00,760 --> 00:32:05,520
Speaker 2: FDA approved in the US for the acute mitigation of

536
00:32:05,640 --> 00:32:09,840
Speaker 2: reflux disease acute gastrosulal reflux disease or GIRD. But when

537
00:32:09,880 --> 00:32:13,920
Speaker 2: you think about what causes reflux, it's insufficient stomach acid production.

538
00:32:14,440 --> 00:32:17,200
Speaker 2: Because when we eat protein, whether it's plant protein or

539
00:32:17,200 --> 00:32:22,240
Speaker 2: animal protein, it's foreign protein. But yet we're in we're

540
00:32:22,320 --> 00:32:25,880
Speaker 2: never designed. Humans are never designed to incorporate foreign proteins

541
00:32:26,080 --> 00:32:28,680
Speaker 2: into human protein. So what do we do. We eat

542
00:32:28,720 --> 00:32:33,240
Speaker 2: the protein. The stomach is made acidic by nature by design,

543
00:32:33,760 --> 00:32:37,080
Speaker 2: because in the acidic environment of the stomach, these proteins

544
00:32:37,080 --> 00:32:40,120
Speaker 2: are broken down in their constituent amino acids. Whether it's

545
00:32:40,120 --> 00:32:42,400
Speaker 2: plant protein or animal protein, you get the twenty one

546
00:32:42,440 --> 00:32:45,440
Speaker 2: constituent amino acids, and then these are absorbed throughout the

547
00:32:45,480 --> 00:32:48,000
Speaker 2: body and then we make human proteins out of those

548
00:32:48,000 --> 00:32:52,480
Speaker 2: amino acids. But without stomach acid, we can't break down

549
00:32:52,520 --> 00:32:55,840
Speaker 2: those proteins into amino acids because this is an acid

550
00:32:55,960 --> 00:32:59,600
Speaker 2: driven reaction. So what happens is our body is smart

551
00:32:59,760 --> 00:33:02,800
Speaker 2: right going. If we eat plant or animal proteins and

552
00:33:02,800 --> 00:33:06,320
Speaker 2: we can't break them down, then the body recognizes this

553
00:33:06,400 --> 00:33:09,480
Speaker 2: is a foreign object and I need to get it out.

554
00:33:09,680 --> 00:33:12,000
Speaker 2: And like just like if you eat, you know, the

555
00:33:12,040 --> 00:33:15,320
Speaker 2: bacterial laden lettuce, or you get food poison, what do

556
00:33:15,360 --> 00:33:18,520
Speaker 2: you do? You throw up because that's your body saying

557
00:33:18,520 --> 00:33:20,600
Speaker 2: I need to get this out of me. So in

558
00:33:20,680 --> 00:33:24,480
Speaker 2: a more subtile way than the body starts to regurgitate

559
00:33:24,600 --> 00:33:27,720
Speaker 2: or expectorate we call it, and that causes a little

560
00:33:27,720 --> 00:33:29,320
Speaker 2: bit of what little bit of acid is there into

561
00:33:29,320 --> 00:33:34,160
Speaker 2: the esophagus and you get gasrisulfhal reflux disease. But it's

562
00:33:34,160 --> 00:33:37,720
Speaker 2: a symptom of insufficient stomach acid production. So why in

563
00:33:37,760 --> 00:33:40,640
Speaker 2: the hell are we suppressing stomach acid. The solution is

564
00:33:40,680 --> 00:33:43,320
Speaker 2: to take apple side of vinegar, acidify the lumin of

565
00:33:43,360 --> 00:33:45,600
Speaker 2: the stomach so you can break down that protein int

566
00:33:45,600 --> 00:33:48,520
Speaker 2: amino acid. You don't get the reflux, you get good digestion,

567
00:33:48,680 --> 00:33:53,360
Speaker 2: you get absorption of you know, nutrients like D vitamins, iron, selenium, chromium,

568
00:33:53,840 --> 00:33:58,040
Speaker 2: you know basic micronutrients. We need stomach acid. So that's

569
00:33:58,160 --> 00:34:02,200
Speaker 2: that's the physiology. Now, these drugs have been on the

570
00:34:02,240 --> 00:34:05,440
Speaker 2: market now for several decades, and in twenty fifteen the

571
00:34:05,520 --> 00:34:10,799
Speaker 2: first kind of longitudinal prospective study came out. Because these

572
00:34:10,880 --> 00:34:14,040
Speaker 2: drugs were only approved for use for three to five days,

573
00:34:14,320 --> 00:34:18,239
Speaker 2: never daily, and never for years. So now in these

574
00:34:18,280 --> 00:34:20,799
Speaker 2: prospective studies you start to see that people have been

575
00:34:20,800 --> 00:34:24,640
Speaker 2: on these antacids for at least three years, forty percent

576
00:34:24,760 --> 00:34:28,480
Speaker 2: greater incidents of heart attack and true, Wow, this isn't risk.

577
00:34:29,160 --> 00:34:32,160
Speaker 2: I'm not talking about risk, I'm talking about actual events.

578
00:34:32,600 --> 00:34:37,280
Speaker 2: Forty percent increase in heart attach's true last year same

579
00:34:37,320 --> 00:34:42,719
Speaker 2: cohort forty percent greater incidents of Alzheimer's and dementia. So

580
00:34:42,760 --> 00:34:46,279
Speaker 2: then you go, okay, these are important clinical observations. What's

581
00:34:46,280 --> 00:34:49,360
Speaker 2: the mechanism. Let's work backwards. What's the mechanism. Why is

582
00:34:49,400 --> 00:34:52,760
Speaker 2: it causing heart attach stroke in Alzheimer's. Well, these proton

583
00:34:52,800 --> 00:34:57,960
Speaker 2: pump inhibitors are increasing what a molecule called asymmetric dimethyl

584
00:34:58,040 --> 00:35:02,400
Speaker 2: largeny or eight m A. It's a metabolite in a

585
00:35:02,480 --> 00:35:07,120
Speaker 2: market that it's measured clinically. Now that inhibits nitrocoxide production

586
00:35:07,560 --> 00:35:09,719
Speaker 2: in the neurons and in the in the ftal cells.

587
00:35:10,360 --> 00:35:12,760
Speaker 2: And if you don't have stomach acid production, you completely

588
00:35:12,840 --> 00:35:17,000
Speaker 2: inhibit the nitrocoxide being produced from swallowing run saliva. So

589
00:35:17,120 --> 00:35:21,040
Speaker 2: this one class of drugs is completely shutting down endogenous

590
00:35:21,120 --> 00:35:25,440
Speaker 2: nitrocoxide production in the human body change part a tech

591
00:35:25,480 --> 00:35:27,080
Speaker 2: stroke Alzheimer's, And.

592
00:35:29,239 --> 00:35:31,960
Speaker 1: It's where you find the nitric oxide having the effect

593
00:35:32,040 --> 00:35:34,239
Speaker 1: through the cardiovascar system and in the brain that we

594
00:35:34,320 --> 00:35:39,640
Speaker 1: talked about in the introduction. Absolutely, that is just mental.

595
00:35:40,160 --> 00:35:44,239
Speaker 1: Now you mentioned apple side of vinegar there and the

596
00:35:44,560 --> 00:35:46,480
Speaker 1: interesting study that I talked about. I don't know if

597
00:35:46,480 --> 00:35:49,200
Speaker 1: you saw the study where they had people take apple

598
00:35:49,239 --> 00:35:51,960
Speaker 1: side of vinegar in the morning. These were overwhe people

599
00:35:53,360 --> 00:35:56,200
Speaker 1: and they I think they had a few different doses,

600
00:35:56,239 --> 00:35:58,799
Speaker 1: but the people who were taking I think it was

601
00:35:59,160 --> 00:36:03,960
Speaker 1: twelve mills of apple side or vinegar and lost about

602
00:36:04,000 --> 00:36:07,480
Speaker 1: seven percent of their body weigh over twelve weeks, right,

603
00:36:07,600 --> 00:36:12,600
Speaker 1: which was just mental and for me that the there

604
00:36:12,640 --> 00:36:15,800
Speaker 1: was obviously a role of the acetate in the vinegar

605
00:36:15,920 --> 00:36:19,480
Speaker 1: being good for the gout microbiome, and I was thinking that,

606
00:36:19,600 --> 00:36:22,800
Speaker 1: but is it also then the apple side of vinegar

607
00:36:23,280 --> 00:36:27,920
Speaker 1: playing a role in better digestion and through the stomach acid.

608
00:36:27,960 --> 00:36:32,080
Speaker 1: So just expand on on that a little bit for us.

609
00:36:32,480 --> 00:36:35,600
Speaker 2: Well, this is basic GI physiology, right, we have to

610
00:36:35,600 --> 00:36:38,279
Speaker 2: have stomach acid, as I talked about to break down

611
00:36:38,280 --> 00:36:41,319
Speaker 2: proteins into amino acids, you have to have stomach acid

612
00:36:41,360 --> 00:36:43,759
Speaker 2: because many nutrients are absorbed in the gastricm coastal of

613
00:36:43,800 --> 00:36:47,759
Speaker 2: the stomach. It's like the vitamins can see irons iodide.

614
00:36:48,239 --> 00:36:51,040
Speaker 2: And then the other important component is when when the

615
00:36:51,120 --> 00:36:53,800
Speaker 2: when we have gastric empty, so when the when the

616
00:36:53,880 --> 00:36:56,480
Speaker 2: valve opens and we release the contents of the stomach

617
00:36:56,560 --> 00:36:59,520
Speaker 2: into the du autumn the proximate part of the small

618
00:36:59,560 --> 00:37:05,120
Speaker 2: intestine that acid dump signals the bile the gallbladder to

619
00:37:05,160 --> 00:37:09,920
Speaker 2: release bio the extreme pancreas to secrete sodium byicard into

620
00:37:09,960 --> 00:37:13,400
Speaker 2: that to neutralize that acid. Without an acid dump, we

621
00:37:13,440 --> 00:37:18,879
Speaker 2: don't get gallbladder function, we get gallstones. The pancreas doesn't

622
00:37:18,920 --> 00:37:21,399
Speaker 2: get the signals to secrete sodium bicards do. We get

623
00:37:21,400 --> 00:37:25,880
Speaker 2: pancrea titis, and then we lose acid base valance because

624
00:37:25,920 --> 00:37:28,920
Speaker 2: it's that acid dump it starts, and it's other hormones,

625
00:37:28,920 --> 00:37:31,680
Speaker 2: it's other secretory, it's you know, leptin in the brain

626
00:37:31,760 --> 00:37:34,920
Speaker 2: to tell you, hey, I'm full stop eating, stop grazing.

627
00:37:35,680 --> 00:37:39,200
Speaker 2: So that acid load from the gastric empty into the

628
00:37:39,280 --> 00:37:42,920
Speaker 2: duodenum is what starts that acid based balance and all

629
00:37:43,000 --> 00:37:46,320
Speaker 2: this signaling in GI physiology that we've known for you know,

630
00:37:46,360 --> 00:37:49,760
Speaker 2: at least my thirty years of education, both high school

631
00:37:49,800 --> 00:37:55,480
Speaker 2: and higher education. I mean that's basic gastric gastro intestinal physiology.

632
00:37:56,320 --> 00:38:00,200
Speaker 1: That is just pretty phenomenal. The role that stumps make

633
00:38:00,280 --> 00:38:03,759
Speaker 1: acid place in that so so apple side of bennigar

634
00:38:04,200 --> 00:38:07,400
Speaker 1: when you're taking that is just is helping the stomach

635
00:38:07,440 --> 00:38:10,920
Speaker 1: acid then then at stomach acid production or is it

636
00:38:11,040 --> 00:38:14,200
Speaker 1: just independently balance it? What what what's the what's the role.

637
00:38:14,280 --> 00:38:15,600
Speaker 1: Is it direct or indirect?

638
00:38:16,600 --> 00:38:18,719
Speaker 2: Well, it's it's certainly direct. I mean I don't I

639
00:38:18,760 --> 00:38:21,040
Speaker 2: don't know what effect it's having on the polleric cells

640
00:38:21,080 --> 00:38:25,400
Speaker 2: and making their own HCl, because if you look at

641
00:38:25,400 --> 00:38:29,880
Speaker 2: that biochemical reaction and in biochemistry, there's certain requirements to

642
00:38:30,320 --> 00:38:32,920
Speaker 2: make the end product right for the polar cells to

643
00:38:32,960 --> 00:38:37,160
Speaker 2: make hydrochloric as, you need idine, you need sodium chloride,

644
00:38:38,160 --> 00:38:42,480
Speaker 2: you need sodium bycar, you need zinc. And yet if

645
00:38:42,480 --> 00:38:45,080
Speaker 2: you can't make stomach acid, you're not absorbing zinc, you're

646
00:38:45,080 --> 00:38:48,080
Speaker 2: not absorbing B vitamins, you're not absorbing idel. So the

647
00:38:48,080 --> 00:38:51,000
Speaker 2: polaric cells can't make HCl. So again, if your body

648
00:38:51,040 --> 00:38:53,160
Speaker 2: can't make it, then we have how do we acidify

649
00:38:53,640 --> 00:38:56,400
Speaker 2: the stomach? And apple side of vinegar is just acetic

650
00:38:56,440 --> 00:38:58,840
Speaker 2: acid as a pH of about two, which is the

651
00:38:58,880 --> 00:39:03,279
Speaker 2: normal pH of the healthy stomach when the poller cells

652
00:39:03,280 --> 00:39:06,800
Speaker 2: are making hydrochloric acid. So I think it's just providing

653
00:39:06,840 --> 00:39:11,480
Speaker 2: an acid environment to an exogenous acid then allows the

654
00:39:11,680 --> 00:39:12,680
Speaker 2: digestion to occur.

655
00:39:13,239 --> 00:39:14,360
Speaker 1: Yeah, and if you start.

656
00:39:14,160 --> 00:39:18,560
Speaker 2: Supplementing with idine and B vitamins and ZC and attain hydrochloride,

657
00:39:19,040 --> 00:39:21,440
Speaker 2: now we can feel the power ex cells production of

658
00:39:21,440 --> 00:39:24,400
Speaker 2: their own hydrochloric acid. And that's that's what that's the

659
00:39:24,440 --> 00:39:26,440
Speaker 2: ultimate goal. Give the body what it needs so the

660
00:39:26,480 --> 00:39:28,399
Speaker 2: body can do its job and then get the hell

661
00:39:28,400 --> 00:39:28,879
Speaker 2: out of the way.

662
00:39:30,400 --> 00:39:33,760
Speaker 1: Let me take a step back, Nathan, and you mentioned

663
00:39:33,800 --> 00:39:39,000
Speaker 1: about the digestion of proteins in the stomach acid and

664
00:39:40,080 --> 00:39:43,279
Speaker 1: is there a role here if somebody is eating a

665
00:39:43,360 --> 00:39:46,160
Speaker 1: high protein diet, which is becoming I think a bit

666
00:39:46,200 --> 00:39:49,040
Speaker 1: more du rigueur, right, and then you have the extreme,

667
00:39:49,600 --> 00:39:54,200
Speaker 1: let's see the extreme of the carnivores. And is there

668
00:39:54,239 --> 00:39:57,520
Speaker 1: an issue with somebody on a carnivore diet who's not

669
00:39:57,640 --> 00:40:00,520
Speaker 1: eating a lot of leafy greens and not getting that

670
00:40:00,680 --> 00:40:06,000
Speaker 1: exogenous source of nitric oxide? What what's the implications have

671
00:40:06,320 --> 00:40:10,960
Speaker 1: you looked at this or is there a theoretical mechanism

672
00:40:11,000 --> 00:40:14,520
Speaker 1: that would be at play here or lack of mechanism.

673
00:40:15,600 --> 00:40:18,399
Speaker 2: I think what's happening, And again I don't have any

674
00:40:18,480 --> 00:40:21,920
Speaker 2: empirical data to support this, but I think what's happening

675
00:40:21,960 --> 00:40:24,640
Speaker 2: is Number One, when you eat a straight carnivore diet,

676
00:40:25,200 --> 00:40:28,440
Speaker 2: you're typically not getting that spike in blood sugar, so

677
00:40:28,480 --> 00:40:33,560
Speaker 2: your insulin sensitivity is improved, you're getting adequate breakdown of proteins,

678
00:40:33,560 --> 00:40:37,000
Speaker 2: you're getting adequate delivery as long as you're not eating

679
00:40:37,600 --> 00:40:40,160
Speaker 2: taking an an acid, which people that I know are

680
00:40:40,200 --> 00:40:43,680
Speaker 2: eating a carnivore diet typically don't take medication because they're

681
00:40:43,719 --> 00:40:46,359
Speaker 2: typically more healthy, they don't need medication. Yeah, but then

682
00:40:46,360 --> 00:40:48,920
Speaker 2: what's happening is that nitric oxide is being produced by

683
00:40:48,920 --> 00:40:52,120
Speaker 2: the lining of the boodvelts, the dial cells is reacting

684
00:40:52,120 --> 00:40:56,880
Speaker 2: with oxyhemoglobin and forming inorganic nitrate in the circulation, and

685
00:40:56,920 --> 00:40:59,480
Speaker 2: then that nitrate is going through the kidneys, it's being

686
00:40:59,520 --> 00:41:04,080
Speaker 2: reabsorbed concentrated in our salvary glands. And this is constant recycling.

687
00:41:04,719 --> 00:41:07,759
Speaker 2: So people who are healthy and have good metabolism and

688
00:41:07,800 --> 00:41:12,080
Speaker 2: have good endothelial function can recycle that nitrate that's produced

689
00:41:12,080 --> 00:41:15,319
Speaker 2: indigenally from the oxidation of microcoxide, and they can get

690
00:41:15,360 --> 00:41:20,200
Speaker 2: away with eating less. God God, all these pathways are intact.

691
00:41:20,200 --> 00:41:23,600
Speaker 1: And because those mechanisms are intact and they're not eating,

692
00:41:23,880 --> 00:41:27,040
Speaker 1: the benefit of is that they're not eating sugar and

693
00:41:27,680 --> 00:41:31,680
Speaker 1: process carbohydrates, so they're not sabotizing that. So they're actually

694
00:41:31,719 --> 00:41:34,719
Speaker 1: allowing their indigenous thing to work. The way that it's

695
00:41:34,760 --> 00:41:37,319
Speaker 1: supposed to work. Interesting.

696
00:41:37,840 --> 00:41:40,280
Speaker 2: Yeah, I think the other thing. Carnivores are very intent

697
00:41:40,400 --> 00:41:42,560
Speaker 2: the ones that I've interacted with, and I've you know,

698
00:41:42,600 --> 00:41:46,520
Speaker 2: I've tried that and I'm you know, I think I'm

699
00:41:46,560 --> 00:41:50,200
Speaker 2: more of a ketogenic type, not straight carnivore. I do

700
00:41:50,640 --> 00:41:54,759
Speaker 2: because I think my motivation is I want to optimize

701
00:41:54,800 --> 00:41:56,600
Speaker 2: my body, right, I want to work out every day.

702
00:41:56,640 --> 00:41:58,759
Speaker 2: I have to have some fuel, but I don't want

703
00:41:58,760 --> 00:42:02,080
Speaker 2: to I don't need six percent body fat right from

704
00:42:02,120 --> 00:42:05,759
Speaker 2: what I do. So, but I think what's happening is

705
00:42:06,400 --> 00:42:09,920
Speaker 2: they're they're typically doing an eighteen hour fast, so it's

706
00:42:09,920 --> 00:42:13,239
Speaker 2: completely resetting their metabolism. These people typically only eat one

707
00:42:13,239 --> 00:42:15,520
Speaker 2: meal a day or between twelve and six and six

708
00:42:15,600 --> 00:42:19,880
Speaker 2: hour period and it's that high protein, good fat, no

709
00:42:20,080 --> 00:42:24,960
Speaker 2: carb intermittent fasting that I think it's fueling that that

710
00:42:25,320 --> 00:42:27,400
Speaker 2: beneficial in cardioprotective phenotype.

711
00:42:28,200 --> 00:42:32,960
Speaker 1: Yeah, very interesting. Let's not I talk about optimizing this,

712
00:42:33,080 --> 00:42:38,719
Speaker 1: let's talk about whole foods versus supplements. So you know,

713
00:42:38,880 --> 00:42:44,040
Speaker 1: obviously anything that any molecule that is being discovered to

714
00:42:44,080 --> 00:42:48,640
Speaker 1: be advantageous, somebody is producing supplements on it. And what's

715
00:42:48,719 --> 00:42:54,400
Speaker 1: your take on the best way to get exogenous nitrate

716
00:42:54,480 --> 00:42:55,240
Speaker 1: into the body.

717
00:42:57,200 --> 00:42:59,319
Speaker 2: Well, it's a difficult ques. I mean, we asked that

718
00:42:59,400 --> 00:43:01,799
Speaker 2: question over ten years ago because the question was how

719
00:43:01,880 --> 00:43:05,120
Speaker 2: much celery, broccoli, led us, spinach or beach do I

720
00:43:05,160 --> 00:43:09,760
Speaker 2: need to eat to get enough nitrate to fuel adequate

721
00:43:09,840 --> 00:43:14,080
Speaker 2: nitroc oxide production. And so we published this in twenty fifteen.

722
00:43:14,120 --> 00:43:15,920
Speaker 2: We went to five cities in the US. We went

723
00:43:15,960 --> 00:43:18,880
Speaker 2: to New York, we went to La Chicago, Dallas, Texas,

724
00:43:18,880 --> 00:43:22,279
Speaker 2: and then Raleigh, North Carolina, and we brought the same

725
00:43:22,360 --> 00:43:25,000
Speaker 2: vegetable from the same retail grocer back to my lab

726
00:43:25,520 --> 00:43:27,760
Speaker 2: and we just analyzed it for the amount of nitrate

727
00:43:27,960 --> 00:43:31,359
Speaker 2: found in that vegetable. And what we found was that

728
00:43:31,800 --> 00:43:37,720
Speaker 2: the nitrate found in cellering in Dallas was forty times

729
00:43:37,719 --> 00:43:40,520
Speaker 2: more than the cellery bought it the same grocer in

730
00:43:40,600 --> 00:43:41,080
Speaker 2: New York.

731
00:43:42,000 --> 00:43:42,360
Speaker 1: Wow.

732
00:43:42,400 --> 00:43:45,960
Speaker 2: So there's regional differences in the same vegetable depending upon

733
00:43:46,040 --> 00:43:50,480
Speaker 2: farming practices, sole conditioned lightning storms which fixes nitrogen in

734
00:43:50,480 --> 00:43:53,840
Speaker 2: the form of nitrate in the soil, And there's difference

735
00:43:53,880 --> 00:43:57,319
Speaker 2: across vegetable categories. And now we're finding the time of

736
00:43:57,400 --> 00:44:01,920
Speaker 2: harvest is a fact, yes, and the amount of sunlight

737
00:44:02,239 --> 00:44:05,759
Speaker 2: is a variable. And then organic versus conventionally grown is

738
00:44:05,760 --> 00:44:08,719
Speaker 2: a variable because organic In that same paper we published

739
00:44:09,120 --> 00:44:12,440
Speaker 2: organically grown vegetables have about five to ten times less

740
00:44:13,440 --> 00:44:14,879
Speaker 2: nitrate than conventionally grown.

741
00:44:15,360 --> 00:44:16,359
Speaker 1: Wow, Because in.

742
00:44:16,320 --> 00:44:19,359
Speaker 2: The US to get an organic label, you can't add

743
00:44:19,440 --> 00:44:24,200
Speaker 2: nitrogen to the soil. Without nitrogen, there's less night trade.

744
00:44:25,080 --> 00:44:28,440
Speaker 2: So it's almost look, it's almost impossible. Yes, No, it

745
00:44:28,520 --> 00:44:31,200
Speaker 2: is impossible to know if you're getting enough unless you

746
00:44:31,280 --> 00:44:33,680
Speaker 2: have analytical equipment like I get where I CAD measured,

747
00:44:34,239 --> 00:44:36,600
Speaker 2: or I actually, you know, grow my own vegetables.

748
00:44:37,080 --> 00:44:40,440
Speaker 1: And that's my next question about growing your own vegetables

749
00:44:40,440 --> 00:44:42,320
Speaker 1: and what you should actually do, what you should be

750
00:44:42,360 --> 00:44:43,360
Speaker 1: adding to the soil.

751
00:44:44,440 --> 00:44:46,840
Speaker 2: Well, you can. Number one, you take a soul sample.

752
00:44:47,239 --> 00:44:49,040
Speaker 2: In the in the US, there's a US Department of

753
00:44:49,080 --> 00:44:52,640
Speaker 2: Agriculture regional office in most counties. So every couple of years,

754
00:44:52,640 --> 00:44:55,080
Speaker 2: I take a soul sample different regions of my pastors.

755
00:44:55,080 --> 00:44:58,480
Speaker 2: I got about eight hundred acres in Texas, So I

756
00:44:58,520 --> 00:45:00,359
Speaker 2: take soul samples and I take it there in tell

757
00:45:00,360 --> 00:45:02,560
Speaker 2: me what's what's in it, but they also tell me

758
00:45:02,600 --> 00:45:05,319
Speaker 2: what's missing. And then especially in the areas where I

759
00:45:05,320 --> 00:45:08,000
Speaker 2: grow my garden and plant my garden, and grow my vegetables.

760
00:45:08,440 --> 00:45:13,120
Speaker 2: I add back what's missing, and it includes fertilizer, nitrogen

761
00:45:13,160 --> 00:45:16,440
Speaker 2: based fertilizers. But so the food that I grow and

762
00:45:16,480 --> 00:45:20,320
Speaker 2: eat is nutrient dense, but it wouldn't be considered organic.

763
00:45:20,840 --> 00:45:23,360
Speaker 2: I don't put herbicides, I don't put pesticides on it.

764
00:45:23,400 --> 00:45:26,880
Speaker 2: But because I'm adding nitrogen based fertilizers to the soul

765
00:45:26,920 --> 00:45:30,720
Speaker 2: as long as potash and phosphorus and sulfur, it wouldn't

766
00:45:30,760 --> 00:45:33,400
Speaker 2: be considered organic. But I can tell you it's the

767
00:45:33,440 --> 00:45:38,360
Speaker 2: most nutrient dense food there is. We test it and

768
00:45:38,400 --> 00:45:41,239
Speaker 2: it's free of herbicides and pesticides. So you know, I'm

769
00:45:41,280 --> 00:45:45,279
Speaker 2: afforded that freedom and kind of flexibility where people who

770
00:45:45,320 --> 00:45:49,000
Speaker 2: live in big cities, I always tell them go to

771
00:45:49,040 --> 00:45:51,880
Speaker 2: the farmers market and ask your farmers how they grow it.

772
00:45:51,920 --> 00:45:56,320
Speaker 2: And you know, consumer demand changes practices and just say

773
00:45:56,360 --> 00:45:59,520
Speaker 2: I want I want nutrient dense food, but I don't

774
00:45:59,520 --> 00:46:02,600
Speaker 2: want herbis sites are pesticides. Yeah, most of the local

775
00:46:02,640 --> 00:46:04,520
Speaker 2: growers subscribe to that.

776
00:46:05,600 --> 00:46:09,680
Speaker 1: Wow, fascinating stuff. And let's jump back, because I think

777
00:46:09,719 --> 00:46:12,400
Speaker 1: we went to it and then I distracted you and

778
00:46:13,040 --> 00:46:17,640
Speaker 1: oral care practices. Oh yes, so, and should we be

779
00:46:17,760 --> 00:46:21,960
Speaker 1: using mouthwashes. Should we be cleaning our tongue? And you

780
00:46:22,000 --> 00:46:26,480
Speaker 1: know what dental hygiene things are going to impact nactec

781
00:46:26,560 --> 00:46:28,640
Speaker 1: oxide production, both good and bad.

782
00:46:29,960 --> 00:46:34,319
Speaker 2: Well, anything that's labeled antiseptic should be avoided. So that

783
00:46:34,360 --> 00:46:37,960
Speaker 2: includes fluorid, fluoride and toothpaste, right. You know in the US,

784
00:46:38,000 --> 00:46:40,120
Speaker 2: I don't know about Australia, but in the US, seventy

785
00:46:40,120 --> 00:46:43,359
Speaker 2: three percent of the municipalities in the US put fluoride

786
00:46:44,040 --> 00:46:45,640
Speaker 2: in the in the in the water supply.

787
00:46:46,080 --> 00:46:49,400
Speaker 1: Yeah, yeah, And I know there's lots of controversy about

788
00:46:49,400 --> 00:46:51,799
Speaker 1: that right now and some are starting to take it out.

789
00:46:53,040 --> 00:46:55,600
Speaker 2: Well, look, it should be taken out because the National

790
00:46:55,640 --> 00:46:59,520
Speaker 2: Toxicology Program published a multi year study last year showing

791
00:46:59,520 --> 00:47:02,160
Speaker 2: that flora and drinking water can lower IQ in kids

792
00:47:02,200 --> 00:47:04,600
Speaker 2: by as much as seven points. So, yes, why do

793
00:47:04,640 --> 00:47:07,200
Speaker 2: they put fluoride in the drinking water Because it kills

794
00:47:07,200 --> 00:47:09,560
Speaker 2: the bacteria in the pipes. So the water you're drinking

795
00:47:09,600 --> 00:47:12,359
Speaker 2: doesn't have any bacteria, but that same florida is gonna

796
00:47:12,440 --> 00:47:17,040
Speaker 2: kill the bacteria in your pipes. You bathe in it,

797
00:47:17,040 --> 00:47:19,719
Speaker 2: it's gonna kill all the bacteria on your skin, You're

798
00:47:19,719 --> 00:47:24,920
Speaker 2: gonna get acne, You're gonna get exema, roseationa dermatitis. It's dangerous,

799
00:47:25,040 --> 00:47:29,400
Speaker 2: it provides no benefit, so take it out. And you

800
00:47:29,400 --> 00:47:33,480
Speaker 2: know fluoride is in most toothpaste, Yes, if you read

801
00:47:33,560 --> 00:47:35,680
Speaker 2: the back of your toothpaste, and I encourage anybody to

802
00:47:35,719 --> 00:47:38,520
Speaker 2: do this, if you're taking a fluorid toothpaste, at least

803
00:47:38,560 --> 00:47:41,600
Speaker 2: in the US, it will say only use a p

804
00:47:41,800 --> 00:47:46,480
Speaker 2: size amount of this toothpaste on your toothbrush because anything

805
00:47:46,560 --> 00:47:50,480
Speaker 2: more than that is gonna cause toxicity from fluoride. And

806
00:47:50,520 --> 00:47:53,759
Speaker 2: if you swallow this, call poison control and it's got

807
00:47:53,800 --> 00:47:56,840
Speaker 2: poison controlled number only if you swallow this. Here's the

808
00:47:56,840 --> 00:47:59,279
Speaker 2: thing that they don't understand because they're not chemist or biochemist.

809
00:48:00,080 --> 00:48:02,560
Speaker 2: Can wait, a fluorid is twenty seven. You do not

810
00:48:02,680 --> 00:48:04,520
Speaker 2: have to swallow a fluorid for it to be toxic.

811
00:48:04,680 --> 00:48:07,200
Speaker 2: It's a small molecule and it's absorbed right across your

812
00:48:07,280 --> 00:48:10,280
Speaker 2: mucous membranes. So you have to get rid of fluoride

813
00:48:10,680 --> 00:48:13,360
Speaker 2: in your toothpaste, in your water because it's antiseptic.

814
00:48:13,880 --> 00:48:17,000
Speaker 1: Wow. And so I use baking so the toothpaste and

815
00:48:17,719 --> 00:48:20,560
Speaker 1: which doesn't have fluorid, and so anybody can can can

816
00:48:20,600 --> 00:48:24,920
Speaker 1: buy that. So so number one, get rid of fluoride

817
00:48:24,960 --> 00:48:30,960
Speaker 1: in your toothpaste and install some sort of water filtration system. Yeah,

818
00:48:31,200 --> 00:48:33,759
Speaker 1: which I have as well, to take that out, and

819
00:48:33,800 --> 00:48:36,200
Speaker 1: then you know, you can have other steps in the

820
00:48:36,239 --> 00:48:40,720
Speaker 1: water filtration that add other things in. Okay, So that's

821
00:48:40,760 --> 00:48:45,600
Speaker 1: that's toothpaste and water. What else. Obviously, mouthwash is a

822
00:48:45,600 --> 00:48:47,280
Speaker 1: bit of a no. No, I'm guessing then.

823
00:48:48,000 --> 00:48:49,600
Speaker 2: Now, Look, you can, you can. I don't watch a

824
00:48:49,640 --> 00:48:51,839
Speaker 2: lot of TV, but when I do, I see these

825
00:48:51,920 --> 00:48:56,279
Speaker 2: these commercials for these antiseptic mouth wash and they're advertising

826
00:48:56,320 --> 00:48:58,520
Speaker 2: this kills ninety nine point nine to nine percent of

827
00:48:58,560 --> 00:49:01,359
Speaker 2: the bacteria in your mouth, and they're proud of it.

828
00:49:01,800 --> 00:49:04,799
Speaker 2: They're proud of it, and they're advertising it for killing you.

829
00:49:06,800 --> 00:49:08,920
Speaker 2: It makes it, you know, it's it would be funny

830
00:49:09,760 --> 00:49:12,120
Speaker 2: if it wasn't such a burden on the healthcare system.

831
00:49:12,239 --> 00:49:15,640
Speaker 2: And people think this is a good idea. I mean nobody,

832
00:49:16,000 --> 00:49:19,120
Speaker 2: nobody today would think it's a good idea to take

833
00:49:19,120 --> 00:49:21,080
Speaker 2: an antibiotic every day for the rest of your life.

834
00:49:21,200 --> 00:49:24,640
Speaker 1: Yes, that's right, exactly. This will killed ninety nine percent

835
00:49:24,760 --> 00:49:26,640
Speaker 1: of your bike biome crack on.

836
00:49:27,880 --> 00:49:30,960
Speaker 2: Yeah, and we and others have published when you do this,

837
00:49:31,120 --> 00:49:33,560
Speaker 2: your blood pressure goes up. Why does your blood pressure

838
00:49:33,600 --> 00:49:37,320
Speaker 2: goes up Because it's killing the nitric oxect producing you

839
00:49:37,480 --> 00:49:41,160
Speaker 2: lose the protective benefits of exercise. I mean again, the

840
00:49:41,239 --> 00:49:43,000
Speaker 2: worst things I could think of would it's the pres

841
00:49:43,040 --> 00:49:46,480
Speaker 2: stomach acid production and use mouthwash and put florid. And

842
00:49:46,560 --> 00:49:48,759
Speaker 2: yet two out of three Americans wake up every day

843
00:49:49,360 --> 00:49:52,080
Speaker 2: and use mouth wash sometimes two three times a day.

844
00:49:52,560 --> 00:49:54,520
Speaker 2: Two out of three Americans have an unsafe elevation in

845
00:49:54,520 --> 00:49:59,840
Speaker 2: blood pressure. This is not coincidental. You have to stop wow.

846
00:50:00,480 --> 00:50:03,799
Speaker 1: And so do you think that if people stop using

847
00:50:03,840 --> 00:50:07,200
Speaker 1: mouthwash and stop using fluoride to his pace and stop

848
00:50:07,320 --> 00:50:12,680
Speaker 1: drinking fluoride, that we would see a significant impact, positive

849
00:50:12,719 --> 00:50:17,560
Speaker 1: impact on both blood pressure and then to buy extension,

850
00:50:17,640 --> 00:50:21,360
Speaker 1: cardiovascular disease and even neurodegender diseases.

851
00:50:22,160 --> 00:50:24,080
Speaker 2: I don't think it. I know it because I've seen it.

852
00:50:24,640 --> 00:50:27,440
Speaker 2: You know. We published a paper in twenty nineteen showing

853
00:50:27,960 --> 00:50:31,560
Speaker 2: that if we take normal tensive patients healthy, We did

854
00:50:31,600 --> 00:50:33,600
Speaker 2: a full oral microp We did this in collaboration with

855
00:50:33,640 --> 00:50:36,680
Speaker 2: the dental school at the Texas Medical Center. Took young

856
00:50:36,760 --> 00:50:40,600
Speaker 2: dental students, dental hygienic students, did a full period exam

857
00:50:40,719 --> 00:50:42,840
Speaker 2: oral exam. We gave them mouthwashed twice a day for

858
00:50:42,880 --> 00:50:46,840
Speaker 2: seven days. After seven days, in some of these kids,

859
00:50:46,880 --> 00:50:50,440
Speaker 2: we saw an a twenty six millimeters of mercury increase

860
00:50:50,480 --> 00:50:53,640
Speaker 2: in their blood pressure. Get seven days of using mouthwash,

861
00:50:54,000 --> 00:50:57,480
Speaker 2: we made people clinically hypertensive. Like We didn't change their diet.

862
00:50:57,680 --> 00:50:59,399
Speaker 2: They were on no medication. The only thing we did

863
00:50:59,480 --> 00:51:04,480
Speaker 2: was kill their microbioden. Blood pressure went up. Later, four

864
00:51:04,560 --> 00:51:07,120
Speaker 2: days later we stop the mouthwashed. Within four days, their

865
00:51:07,120 --> 00:51:11,480
Speaker 2: blood pressure comes down. Their microbiome had completely repopulated. We

866
00:51:11,560 --> 00:51:16,239
Speaker 2: do tongue scrapings and quantify and culture the bacteria. So

867
00:51:16,320 --> 00:51:19,120
Speaker 2: we see this. This isn't association. This is now we

868
00:51:19,239 --> 00:51:24,480
Speaker 2: established causation. You eradicate the bacteria, you decrease nitric oxide production,

869
00:51:24,520 --> 00:51:28,040
Speaker 2: blood pressure goes up. Hypertension is the number one driver

870
00:51:28,160 --> 00:51:30,759
Speaker 2: of the number one killer of the Yeah.

871
00:51:30,760 --> 00:51:33,719
Speaker 4: Absolutely, if you think about the public health effects of that,

872
00:51:34,120 --> 00:51:37,760
Speaker 4: get rid of fluoride, stop using mouthwash, restore your nitroc

873
00:51:37,760 --> 00:51:42,000
Speaker 4: oxide production, blood pressure comes down, The incidents and impact

874
00:51:42,080 --> 00:51:44,319
Speaker 4: on cardiovaster disease will go away.

875
00:51:44,320 --> 00:51:47,200
Speaker 2: And that's what we're seeing. It explains resistant hypertension.

876
00:51:48,120 --> 00:51:52,680
Speaker 1: You need Sorry, did you publish that paper, that intervention.

877
00:51:54,440 --> 00:51:59,560
Speaker 1: Why was this not front page news all around the

878
00:51:59,600 --> 00:52:00,400
Speaker 1: freaking worded.

879
00:52:02,120 --> 00:52:04,759
Speaker 2: You know, we got a little bit of pressed. I

880
00:52:04,800 --> 00:52:06,600
Speaker 2: was on the Doctor show here in the US, and

881
00:52:07,200 --> 00:52:10,520
Speaker 2: you know, a couple of news segments picked it up.

882
00:52:10,520 --> 00:52:13,160
Speaker 2: But no, it wasn't. I mean, it kind of fizzle.

883
00:52:13,360 --> 00:52:17,080
Speaker 2: But you know, this is disruptive. Think about if what

884
00:52:17,120 --> 00:52:19,680
Speaker 2: we say is true, and it absolutely is because it's

885
00:52:19,680 --> 00:52:23,040
Speaker 2: been reproduced by many other labs. We have to change

886
00:52:23,040 --> 00:52:25,560
Speaker 2: the way we're doing things. Dental medicine has to change.

887
00:52:25,600 --> 00:52:27,560
Speaker 2: We got to stop the fluoride rentism and go for

888
00:52:27,560 --> 00:52:30,279
Speaker 2: our annual checkups. These companies have to get rid of

889
00:52:30,280 --> 00:52:33,440
Speaker 2: fluoride from their toothpaste. It provides no benefit and it's

890
00:52:33,440 --> 00:52:36,799
Speaker 2: all risk. And antiseptic mouthwashes have to be taken off

891
00:52:36,800 --> 00:52:39,120
Speaker 2: the market. I mean, I say that, but there has

892
00:52:39,120 --> 00:52:42,600
Speaker 2: to be more judicious use of this because in people

893
00:52:42,640 --> 00:52:47,120
Speaker 2: with oral pathogens that lead to systemic inflammation and translocation,

894
00:52:47,239 --> 00:52:52,080
Speaker 2: increaphysical heart attack and stroke, and you know, valular problems

895
00:52:52,080 --> 00:52:55,000
Speaker 2: and myocarditis and things like that, there has to be

896
00:52:55,120 --> 00:52:59,840
Speaker 2: judicious use of antiseptics and antibiotics in the patients. But

897
00:53:00,080 --> 00:53:03,960
Speaker 2: it's not something you should do prophylactically everybody for no

898
00:53:04,040 --> 00:53:04,840
Speaker 2: reason whatsoever.

899
00:53:05,080 --> 00:53:08,960
Speaker 1: Yeah, gotcha? Okay, And what about tongue scraping?

900
00:53:09,719 --> 00:53:10,279
Speaker 2: Should people?

901
00:53:10,400 --> 00:53:12,640
Speaker 1: Should people do that or not? No?

902
00:53:12,800 --> 00:53:16,640
Speaker 2: Interestingly, in that same paper, you know, we provide diaries

903
00:53:16,640 --> 00:53:20,480
Speaker 2: for these kids, and interestingly, some of these dental students

904
00:53:20,840 --> 00:53:22,800
Speaker 2: maybe twenty thirty I think go back can read the paper.

905
00:53:23,040 --> 00:53:26,319
Speaker 2: We're doing tongue scrapings, and what we found was the

906
00:53:26,400 --> 00:53:30,359
Speaker 2: people who were tongue scraping tongue scraping alone had better

907
00:53:30,440 --> 00:53:33,440
Speaker 2: blood pressure management, and they had a greater diversity of

908
00:53:33,480 --> 00:53:36,440
Speaker 2: the oral microbiome that we could culture from tongue scrapings.

909
00:53:36,960 --> 00:53:39,400
Speaker 2: But if you tongue scrape the people who did the

910
00:53:39,400 --> 00:53:42,360
Speaker 2: tongue scraping and then were given the aniseptic had the

911
00:53:42,440 --> 00:53:47,279
Speaker 2: highest increase in pressure. So tongue scraping alone is good.

912
00:53:47,920 --> 00:53:53,040
Speaker 2: Tongue scraping with use of aniseptic is it exacerbates the damage?

913
00:53:53,560 --> 00:53:57,760
Speaker 1: Yeah, as many things in signs, and the answer should

914
00:53:57,760 --> 00:53:59,840
Speaker 1: start with it depends.

915
00:54:00,120 --> 00:54:03,919
Speaker 2: Pins There is no one size fits all, no matter

916
00:54:03,920 --> 00:54:04,640
Speaker 2: how hard we try.

917
00:54:05,320 --> 00:54:09,000
Speaker 1: So what do you think are Let's talk about habits

918
00:54:09,000 --> 00:54:12,520
Speaker 1: then that people can do. I think anybody listening to

919
00:54:12,600 --> 00:54:17,080
Speaker 1: this is nigh on the nitric oxide tree, and we'll

920
00:54:17,120 --> 00:54:20,960
Speaker 1: talk about your book, because obviously they should be behind

921
00:54:21,040 --> 00:54:26,920
Speaker 1: your book. But give us the lifestyle practices that you recommend,

922
00:54:26,920 --> 00:54:30,279
Speaker 1: all that you do right in order to optimize your

923
00:54:30,360 --> 00:54:32,719
Speaker 1: nitric oxide I'm always interested in talking to people who

924
00:54:32,719 --> 00:54:34,880
Speaker 1: are experts in a particular way and say, what do

925
00:54:34,920 --> 00:54:37,000
Speaker 1: you do about this in terms of your life style.

926
00:54:37,760 --> 00:54:41,120
Speaker 2: Well, I'm the inequal one guinea pig for the past

927
00:54:41,160 --> 00:54:43,520
Speaker 2: twenty five years, so yeah, I've worked through a lot

928
00:54:43,560 --> 00:54:45,560
Speaker 2: of this to figure out what works for me. But

929
00:54:45,760 --> 00:54:47,879
Speaker 2: I think these are I think for the most part,

930
00:54:47,920 --> 00:54:51,239
Speaker 2: these are generally accepted principles. But number one, I do

931
00:54:51,280 --> 00:54:54,239
Speaker 2: an eighteen hour fast every day. I typically eat my

932
00:54:54,320 --> 00:54:56,919
Speaker 2: last meal at six pm, and I don't eat until noon.

933
00:54:56,960 --> 00:54:59,400
Speaker 2: The next thing, I don't eat breakfast. I drink two

934
00:54:59,440 --> 00:55:01,400
Speaker 2: cups of coffe with just a tad bit of honey

935
00:55:01,719 --> 00:55:03,960
Speaker 2: in a local honey that helps my allergies.

936
00:55:05,400 --> 00:55:09,560
Speaker 1: Can I ask, is that purely for the metabolic effects

937
00:55:09,600 --> 00:55:12,920
Speaker 1: and the metabolic flexibility of fasting and all the benefits

938
00:55:12,920 --> 00:55:17,280
Speaker 1: of fasting, or is that also to stimulate nitric oxide

939
00:55:17,320 --> 00:55:19,600
Speaker 1: production in some mechanism.

940
00:55:21,000 --> 00:55:23,920
Speaker 2: I don't have any evidence that it's affecting nitric oxide

941
00:55:23,960 --> 00:55:27,840
Speaker 2: production per se. But if you look at the science

942
00:55:27,960 --> 00:55:31,320
Speaker 2: and the longevity genes that are turned on by chloric restriction,

943
00:55:31,440 --> 00:55:36,239
Speaker 2: intermittent fasting and mitochondri biogenesis and improving your metabolic flexibility,

944
00:55:36,520 --> 00:55:38,960
Speaker 2: and I just know, for me, it just made me

945
00:55:39,000 --> 00:55:42,040
Speaker 2: feel better. You know, the hunger pan I don't get hungry,

946
00:55:42,040 --> 00:55:45,920
Speaker 2: the hunger, and then my belly fat just I mean,

947
00:55:46,000 --> 00:55:48,480
Speaker 2: it was like it melted off, and that's the most stubborn,

948
00:55:48,880 --> 00:55:50,880
Speaker 2: difficult fat to get rid of. And just the intermittent

949
00:55:50,880 --> 00:55:53,880
Speaker 2: fasting and then watching what I eat. So typically I

950
00:55:53,880 --> 00:55:56,360
Speaker 2: eat a lot of protein. I raise my own beef,

951
00:55:56,440 --> 00:55:59,440
Speaker 2: I grow my own vegetables, and then I drink a

952
00:55:59,480 --> 00:56:03,280
Speaker 2: lot of good filtered water. And then I exercise every morning.

953
00:56:03,320 --> 00:56:04,840
Speaker 2: So every morning when I wake up, I spend the

954
00:56:04,880 --> 00:56:08,759
Speaker 2: first fifteen twenty minutes doing high intensity interval training. So

955
00:56:08,880 --> 00:56:12,600
Speaker 2: that gets my blood splow going, it gets my heart pumping.

956
00:56:12,680 --> 00:56:15,840
Speaker 2: I'm breathing, I'm focusing on nasal breathing and mouth breathing.

957
00:56:16,360 --> 00:56:18,160
Speaker 2: And then I go sit in an infrared SNA for

958
00:56:18,200 --> 00:56:20,120
Speaker 2: thirty minutes at one hundred and seventy degrees because that

959
00:56:20,200 --> 00:56:24,800
Speaker 2: infrared light is activating mitochondria, it's improving microcotside release.

960
00:56:25,600 --> 00:56:28,240
Speaker 1: Yes, can we can we do a little dive into

961
00:56:28,280 --> 00:56:35,960
Speaker 1: this because the world of photobiomodulation will absolutely spin people

962
00:56:36,160 --> 00:56:41,960
Speaker 1: out right. And the impact on the mitochondria through cytochrome

963
00:56:42,000 --> 00:56:46,800
Speaker 1: c oxides and other mechanisms, and even some of the

964
00:56:46,840 --> 00:56:50,719
Speaker 1: stuff that's coming out about neurodegenerative diseases and how they're

965
00:56:50,760 --> 00:56:56,360
Speaker 1: reacting to near infrared light and the quantum effects of

966
00:56:56,480 --> 00:57:01,319
Speaker 1: light will just fucking spin people. I put it so quick,

967
00:57:01,320 --> 00:57:03,719
Speaker 1: could do another whole podcast of this, but maybe just

968
00:57:03,760 --> 00:57:09,120
Speaker 1: give us the five minute view on light and particularly

969
00:57:09,120 --> 00:57:12,760
Speaker 1: red and near infrared and the impacts on our body

970
00:57:12,760 --> 00:57:14,840
Speaker 1: in a mitochondria and nitric oxide production.

971
00:57:15,719 --> 00:57:17,760
Speaker 2: Well, I'll take you back to nineteen fifty seven and

972
00:57:17,800 --> 00:57:21,320
Speaker 2: Bob Firschcott, who was won the Nobel Pride for discovery nitrocoxide,

973
00:57:21,560 --> 00:57:25,280
Speaker 2: introduced this concept of photo relaxation. So he could take

974
00:57:25,360 --> 00:57:28,160
Speaker 2: isolated blood vessels and shine certain wavelengths of light and

975
00:57:28,200 --> 00:57:32,240
Speaker 2: you could see this transient relaxation. And then if he

976
00:57:32,280 --> 00:57:35,840
Speaker 2: preloaded those with nitrocoxide and then shine that same light

977
00:57:36,240 --> 00:57:40,000
Speaker 2: wavelength of light, you could potentiate the vaso dilatory responses

978
00:57:40,880 --> 00:57:43,000
Speaker 2: We published on this in two thousand and two, over

979
00:57:43,320 --> 00:57:46,520
Speaker 2: almost twenty five years ago, that these photo labile stores

980
00:57:46,520 --> 00:57:49,680
Speaker 2: of nitrocoxide can be modulated. So once nyitrocoxide's produced, they

981
00:57:49,680 --> 00:57:53,520
Speaker 2: can be stored and then activated upon by light and

982
00:57:53,560 --> 00:57:57,640
Speaker 2: then released to initiate vaso relaxation. And that's why sunlight,

983
00:57:57,840 --> 00:58:00,720
Speaker 2: you know, the entire visible spectrum of sun and why

984
00:58:00,760 --> 00:58:03,480
Speaker 2: sunlight twenty thirty minutes direct sunlight a day is important

985
00:58:03,960 --> 00:58:08,160
Speaker 2: because it's releasing these nitrocoxide stores and lowering blood pressure.

986
00:58:08,680 --> 00:58:12,000
Speaker 2: And if you look epidemiologically, people live in Scandinavian the

987
00:58:12,120 --> 00:58:14,920
Speaker 2: Arctic have lower bod or higher blood pressures than people

988
00:58:14,920 --> 00:58:16,200
Speaker 2: live at the equator.

989
00:58:16,320 --> 00:58:22,280
Speaker 1: And no than Northern Island where I'm from, than the creature.

990
00:58:23,680 --> 00:58:27,800
Speaker 2: Yeah you got cloudy, rainy days, you're right. But now

991
00:58:27,800 --> 00:58:30,680
Speaker 2: that the infrared, the full infrared spectrum is part of

992
00:58:30,800 --> 00:58:34,720
Speaker 2: what this is. And you know the mitochondria are like chloroplast, right,

993
00:58:34,720 --> 00:58:39,840
Speaker 2: they're chromophores, and so this light is initiating biochemistry and

994
00:58:39,880 --> 00:58:43,280
Speaker 2: it's as you call it, photo biomodulation. So when you

995
00:58:43,280 --> 00:58:46,800
Speaker 2: have adequate nitrocoxiding to go to an infrared sonam it's

996
00:58:46,880 --> 00:58:50,040
Speaker 2: not just part of detoxification, but it's improving blood flow

997
00:58:50,120 --> 00:58:54,840
Speaker 2: and you know, detoxing and mobilizing these toxins, but that

998
00:58:54,960 --> 00:58:59,320
Speaker 2: light energy is improving mitochondri function, is releasing nitrocoxide gas.

999
00:59:00,360 --> 00:59:03,680
Speaker 1: Yeah, it's really interesting because there's a massive debate in

1000
00:59:03,720 --> 00:59:09,800
Speaker 1: the whole sauna world about traditional versus infrared saunas, right,

1001
00:59:09,840 --> 00:59:13,920
Speaker 1: and most of them will will quite rightly say, you know,

1002
00:59:14,000 --> 00:59:17,280
Speaker 1: the diehards will go most of the research around the

1003
00:59:17,320 --> 00:59:20,480
Speaker 1: benefits are from a traditional sauna. Now I have an

1004
00:59:20,560 --> 00:59:24,280
Speaker 1: infrared sauna and I himmed and had over which one

1005
00:59:24,360 --> 00:59:28,200
Speaker 1: to actually get, but I and I ended up going

1006
00:59:28,240 --> 00:59:32,000
Speaker 1: for the infrared and just and I think the reason

1007
00:59:32,040 --> 00:59:35,600
Speaker 1: why people are so pro the traditional it's just that

1008
00:59:35,680 --> 00:59:40,040
Speaker 1: there's decades more research on that type of sauna. And

1009
00:59:40,400 --> 00:59:43,600
Speaker 1: you know, the hardcore ones are going, well, it is

1010
00:59:43,720 --> 00:59:46,920
Speaker 1: about the activation of heat shock proteins. And you have

1011
00:59:46,960 --> 00:59:49,960
Speaker 1: to raise your core body temperature by one degree, I

1012
00:59:50,040 --> 00:59:54,120
Speaker 1: tell you, and my infrared sauna, I and it only

1013
00:59:54,120 --> 00:59:57,080
Speaker 1: goes up to seventy This is centigrade. I can't remember

1014
00:59:57,160 --> 01:00:01,880
Speaker 1: what that is fahrenheit, but it's below significantly below. But

1015
01:00:02,080 --> 01:00:05,240
Speaker 1: I sweat way more in an infrared so on that

1016
01:00:05,320 --> 01:00:09,400
Speaker 1: than I do in a traditional sauna, and I think

1017
01:00:09,440 --> 01:00:11,880
Speaker 1: there's going to be more and more research coming out

1018
01:00:12,040 --> 01:00:16,480
Speaker 1: about the independent benefits of the infrared sona.

1019
01:00:17,320 --> 01:00:19,480
Speaker 2: Well, I think it's I think so, I mean, it's

1020
01:00:19,520 --> 01:00:22,720
Speaker 2: what we call biostacking. Right, So traditional sna' is just

1021
01:00:22,720 --> 01:00:25,240
Speaker 2: gonna heat you up, yes, right, and you're breathing in

1022
01:00:25,240 --> 01:00:27,880
Speaker 2: that air, and most pathogens, whether the viral bacteria, can't

1023
01:00:27,920 --> 01:00:30,960
Speaker 2: survive that high heat. So it's it's helping your immune function.

1024
01:00:31,040 --> 01:00:33,800
Speaker 2: It's helping and you know, induction heat chop proteins and

1025
01:00:33,800 --> 01:00:36,760
Speaker 2: things like that. When you combine the heat with the

1026
01:00:36,800 --> 01:00:40,400
Speaker 2: infrared light, it's kind of it's biostacking. You're getting an

1027
01:00:40,400 --> 01:00:42,280
Speaker 2: additional benefit from them. And then what I do is

1028
01:00:42,280 --> 01:00:45,640
Speaker 2: I put an ozone generator in my sauna. So now

1029
01:00:45,680 --> 01:00:50,200
Speaker 2: I'm creating ozone superoxygenating my blood and it's helping with

1030
01:00:50,280 --> 01:00:55,880
Speaker 2: any you know, bacteria problem or dys biosis. And you know,

1031
01:00:55,920 --> 01:00:58,160
Speaker 2: I breathe it in. It's not it's a very low dose.

1032
01:00:59,240 --> 01:01:01,280
Speaker 2: And then after that, I mean that it's one hundred

1033
01:01:01,320 --> 01:01:03,280
Speaker 2: and seventy degrees fahrenheit, which I think is a little

1034
01:01:03,280 --> 01:01:05,560
Speaker 2: bit more than seven degrees centigrade and then I go

1035
01:01:05,600 --> 01:01:07,680
Speaker 2: from one hundred and seventy degrees to a thirty seven

1036
01:01:07,680 --> 01:01:09,760
Speaker 2: degree ice bath, and then I do yeah, yeah, and

1037
01:01:09,800 --> 01:01:11,920
Speaker 2: a half minutes or try to get three minutes. But

1038
01:01:12,360 --> 01:01:13,400
Speaker 2: it's so painful.

1039
01:01:13,440 --> 01:01:16,919
Speaker 1: Yeah, that's that. Yeah, that's hard. And look, I think

1040
01:01:16,960 --> 01:01:19,840
Speaker 1: a lot of those benefits. I interviewed Professor Mike Tipton

1041
01:01:20,280 --> 01:01:23,640
Speaker 1: on my podcast. He's done a lot of the actual

1042
01:01:23,680 --> 01:01:28,040
Speaker 1: studies on coldwater therapy, and he said that the majority

1043
01:01:28,120 --> 01:01:31,520
Speaker 1: of the benefits we actually get in the first ten

1044
01:01:31,640 --> 01:01:37,919
Speaker 1: or fifteen seconds, and even below around ten degrees centigrade water,

1045
01:01:37,960 --> 01:01:40,640
Speaker 1: which I think is about fifty ish, he said, is

1046
01:01:41,080 --> 01:01:42,800
Speaker 1: enough to trigger. So I don't think we need to

1047
01:01:42,800 --> 01:01:45,200
Speaker 1: go as hardcore in the cold as we used to

1048
01:01:45,280 --> 01:01:49,880
Speaker 1: think that we did. But it is, it's beneficial, and

1049
01:01:49,960 --> 01:01:52,680
Speaker 1: anybody does it feels prigging amazing.

1050
01:01:53,360 --> 01:01:56,000
Speaker 2: Now, Look I hate it. I do it every morning

1051
01:01:56,120 --> 01:01:59,400
Speaker 2: and I absolutely hate it. You know, it's just it's

1052
01:01:59,400 --> 01:02:02,480
Speaker 2: two and a half minutes. But for me, it's a

1053
01:02:02,520 --> 01:02:06,040
Speaker 2: mental preparation and it prepares me. You know, life is hard.

1054
01:02:06,600 --> 01:02:09,280
Speaker 2: You have to mentally prepare ourselves for the tough times

1055
01:02:09,280 --> 01:02:11,680
Speaker 2: in life. So for me, it's that mental exercise where

1056
01:02:11,680 --> 01:02:14,240
Speaker 2: I'm preparing myself. I'm coming into my breath and I

1057
01:02:14,400 --> 01:02:16,200
Speaker 2: just do it. You just you do it. It's like

1058
01:02:16,240 --> 01:02:17,680
Speaker 2: the Nike commercial, Just do it.

1059
01:02:17,880 --> 01:02:19,680
Speaker 1: Yeah, it was get in there.

1060
01:02:19,600 --> 01:02:21,880
Speaker 2: And suck it up. You come into your breath, and

1061
01:02:21,920 --> 01:02:24,480
Speaker 2: then once the shivering stops, you know, five minutes after him,

1062
01:02:24,800 --> 01:02:27,760
Speaker 2: you feel amazing that. What I've noticed is again it's

1063
01:02:27,800 --> 01:02:32,280
Speaker 2: it's helping that that white inflammatory fat turn into brown fat,

1064
01:02:32,320 --> 01:02:36,320
Speaker 2: which is thermogenic, and then you lose the fat, especially

1065
01:02:36,360 --> 01:02:41,200
Speaker 2: the visceral fat, and it's amazing transformation. So that's my morning.

1066
01:02:41,280 --> 01:02:43,919
Speaker 2: That's one hour. If I waited till I had time

1067
01:02:43,960 --> 01:02:45,240
Speaker 2: to do it, I would never do it. So what

1068
01:02:45,280 --> 01:02:47,240
Speaker 2: I do. I wake up an hour earlier than I

1069
01:02:47,280 --> 01:02:49,640
Speaker 2: typically did, and that's the first hour of the day.

1070
01:02:49,680 --> 01:02:53,080
Speaker 2: It's focused on me physical health, it's my spiritual health.

1071
01:02:53,120 --> 01:02:57,080
Speaker 2: I'm I'm praying, I'm meditating, I'm reading scripture, and I'm

1072
01:02:57,480 --> 01:03:00,480
Speaker 2: I'm getting my motive. How do I start the day?

1073
01:03:00,520 --> 01:03:02,960
Speaker 2: How do I execute my plan? And how do I

1074
01:03:03,080 --> 01:03:04,600
Speaker 2: outwork everybody on the planet.

1075
01:03:05,040 --> 01:03:07,960
Speaker 1: Yeah, and you are starting your day with a very

1076
01:03:08,000 --> 01:03:11,800
Speaker 1: good dose of hormetic stressors. And I'll tell you I

1077
01:03:11,840 --> 01:03:15,600
Speaker 1: can see as you said, you know, it's mental prep

1078
01:03:15,640 --> 01:03:17,160
Speaker 1: and and and it's hard and you've got to do

1079
01:03:17,200 --> 01:03:20,000
Speaker 1: hard stuff. I know about half of my listeners are going,

1080
01:03:20,080 --> 01:03:23,440
Speaker 1: oh fuck, don't start Paul on what we have to

1081
01:03:23,480 --> 01:03:25,920
Speaker 1: do hard stuff, because he's got to go on for

1082
01:03:26,000 --> 01:03:27,320
Speaker 1: about three rds.

1083
01:03:27,960 --> 01:03:30,520
Speaker 2: I will not looking for the easy life. This is

1084
01:03:30,600 --> 01:03:32,480
Speaker 2: living on this planet. Isn't for you.

1085
01:03:32,520 --> 01:03:35,880
Speaker 1: No, that's right, that's right exactly. But I think to

1086
01:03:35,960 --> 01:03:39,600
Speaker 1: your point that that you know, doing the hard stuff

1087
01:03:40,400 --> 01:03:42,720
Speaker 1: in the morning, whether it's you're turning your lovely warm

1088
01:03:42,760 --> 01:03:44,640
Speaker 1: short of cold, or you're getting in this song and

1089
01:03:44,640 --> 01:03:49,520
Speaker 1: you're getting in an ice bath, there's a huge psychological

1090
01:03:49,640 --> 01:03:53,680
Speaker 1: benefit I think, as well as the physiological benefit from

1091
01:03:53,720 --> 01:03:58,560
Speaker 1: the hormetic stressors that that I don't think can be overstated.

1092
01:03:59,200 --> 01:04:00,000
Speaker 1: Are really doing.

1093
01:04:00,360 --> 01:04:02,600
Speaker 2: Now for me. I'm addicted to it now. I mean

1094
01:04:02,880 --> 01:04:05,920
Speaker 2: I have to. If I don't do it, it's I

1095
01:04:05,920 --> 01:04:08,640
Speaker 2: have a guilt number one and number two, I just

1096
01:04:08,680 --> 01:04:11,560
Speaker 2: don't feel as good. So I wake up every morning

1097
01:04:11,680 --> 01:04:14,320
Speaker 2: and actually look forward to that routine. I don't look

1098
01:04:14,360 --> 01:04:17,600
Speaker 2: forward to the code plunge that that whole routine I

1099
01:04:17,720 --> 01:04:20,560
Speaker 2: look forward to, but it forces me to do it.

1100
01:04:20,600 --> 01:04:23,760
Speaker 2: Because the way that I feel since doing that over

1101
01:04:23,800 --> 01:04:27,080
Speaker 2: the past probably maybe a year, year and a half. Yeah,

1102
01:04:27,160 --> 01:04:28,560
Speaker 2: I mean I don't I don't want to go back

1103
01:04:28,600 --> 01:04:30,960
Speaker 2: to before that. So I continue to do it every morning,

1104
01:04:30,960 --> 01:04:33,240
Speaker 2: whether I want to or not. But now I want to.

1105
01:04:33,360 --> 01:04:33,880
Speaker 2: It's a habit.

1106
01:04:34,720 --> 01:04:37,720
Speaker 1: Yeah, they appreciate the pudding. And given that I've got you,

1107
01:04:37,960 --> 01:04:41,320
Speaker 1: I want to ask your opinion on other stuff because

1108
01:04:41,360 --> 01:04:46,840
Speaker 1: you you clearly know physiology very deeply. What you're thinking

1109
01:04:47,160 --> 01:04:52,000
Speaker 1: on some of the other longevity bio hacks out there, right,

1110
01:04:52,080 --> 01:04:56,080
Speaker 1: So particularly let's talk about a few compounds, So ANIMN

1111
01:04:56,120 --> 01:04:59,760
Speaker 1: and an R have you have you formulated any thoughts

1112
01:05:00,200 --> 01:05:01,880
Speaker 1: those at the minute?

1113
01:05:02,640 --> 01:05:04,560
Speaker 2: You know what I do. I mean, I certainly understand

1114
01:05:04,640 --> 01:05:08,520
Speaker 2: NAD and nadph and all these these are essentral cofactors.

1115
01:05:08,560 --> 01:05:11,000
Speaker 2: And you know a degree in biochemistry and a PhD

1116
01:05:11,080 --> 01:05:14,400
Speaker 2: molector and sound physiology. Certainly these are important cofactors in

1117
01:05:14,440 --> 01:05:18,720
Speaker 2: biochemical reactions. But again, just like in most physiological mailochemical systems,

1118
01:05:18,760 --> 01:05:22,560
Speaker 2: they'll recycle. So what do you take what's in the blood,

1119
01:05:22,600 --> 01:05:24,560
Speaker 2: does it actually get into the cell? And is it biology?

1120
01:05:24,720 --> 01:05:28,480
Speaker 1: Does effect? And these more better? Right?

1121
01:05:28,760 --> 01:05:33,560
Speaker 2: And unless you have some you know genetic deficiency or polymorphism.

1122
01:05:33,920 --> 01:05:37,320
Speaker 2: You know that your body can't produce it, and taking

1123
01:05:37,320 --> 01:05:40,080
Speaker 2: its supplemental may provide benefit. You know, I can tell

1124
01:05:40,120 --> 01:05:42,640
Speaker 2: you when things like this come out. I try them,

1125
01:05:43,200 --> 01:05:45,200
Speaker 2: and I'm pretty in tune with my body. So I've

1126
01:05:45,200 --> 01:05:48,320
Speaker 2: taken NAD, I've done iv NA D. I take in

1127
01:05:48,360 --> 01:05:51,840
Speaker 2: and in as a daily supplement. Do I notice any different?

1128
01:05:53,120 --> 01:05:56,040
Speaker 2: Probably not. Do I think it's you know, I take

1129
01:05:56,080 --> 01:05:57,600
Speaker 2: it because a lot of these companies give it to

1130
01:05:57,640 --> 01:05:58,840
Speaker 2: me free. If I had to buy it when I

1131
01:05:58,920 --> 01:06:06,240
Speaker 2: take it, maybe I don't know. One am I have

1132
01:06:06,360 --> 01:06:09,400
Speaker 2: with biohacking is you've got these biohackers have millions of followers,

1133
01:06:09,400 --> 01:06:15,480
Speaker 2: influencing millions of people who have no pedigree, no education,

1134
01:06:16,320 --> 01:06:19,280
Speaker 2: no degree. They're not scientists, they're not doctors. They're making

1135
01:06:19,840 --> 01:06:24,040
Speaker 2: recommendations and influencing millions of people, and many times it's

1136
01:06:24,080 --> 01:06:25,520
Speaker 2: not based on valid science.

1137
01:06:25,800 --> 01:06:28,960
Speaker 1: Yeah, and they're getting pedi chetoad of money to produce them. Right.

1138
01:06:29,080 --> 01:06:35,040
Speaker 1: This is the thing that I'm sitting on the fence

1139
01:06:35,200 --> 01:06:38,760
Speaker 1: on the on the NAD stuff because I looked at

1140
01:06:38,760 --> 01:06:40,640
Speaker 1: that I did ticket earlier, and I thought, Jesus, this

1141
01:06:40,760 --> 01:06:43,480
Speaker 1: shit's expensive, and I don't actually know what it's doing.

1142
01:06:43,680 --> 01:06:47,760
Speaker 1: And the studies, you know, the studies currently are mostly

1143
01:06:47,960 --> 01:06:50,680
Speaker 1: animal biists and there are some human ones, but they

1144
01:06:50,720 --> 01:06:54,720
Speaker 1: are industry sponsored, which always gives me into of skepticism.

1145
01:06:55,600 --> 01:06:58,680
Speaker 1: But having said that, you know, there is a a

1146
01:06:58,920 --> 01:07:01,840
Speaker 1: row of any obviously in the body, and it does

1147
01:07:01,920 --> 01:07:05,200
Speaker 1: decline with you. So it's it's interesting, but for me,

1148
01:07:05,920 --> 01:07:07,840
Speaker 1: I'm not going to spend my heart or in cash

1149
01:07:07,880 --> 01:07:12,880
Speaker 1: on it until I start to see more bigger human studies.

1150
01:07:12,960 --> 01:07:16,840
Speaker 1: Like if you look at nitric oxide and the research

1151
01:07:16,920 --> 01:07:20,720
Speaker 1: around that, the NAD stuff, it's nowhere near that ship.

1152
01:07:20,840 --> 01:07:22,880
Speaker 1: And as I always say, a lot of these people

1153
01:07:23,200 --> 01:07:26,280
Speaker 1: are taking frigging NAD, N and N and they're taking

1154
01:07:26,320 --> 01:07:29,800
Speaker 1: this supplement and that supplement this, and they're not frigging exercising,

1155
01:07:29,920 --> 01:07:32,320
Speaker 1: and they're not going in a in a cold plunt

1156
01:07:32,360 --> 01:07:34,640
Speaker 1: and they're not they're not using a sauna. It's like,

1157
01:07:35,400 --> 01:07:38,600
Speaker 1: you know, these are the really big things over here

1158
01:07:38,680 --> 01:07:41,920
Speaker 1: that you're not doing, and you're you're you're wanting all

1159
01:07:42,040 --> 01:07:45,000
Speaker 1: these little tiny things to make up for it. It's like,

1160
01:07:45,560 --> 01:07:48,600
Speaker 1: so for me, these are potential add ons when you

1161
01:07:48,720 --> 01:07:51,000
Speaker 1: get that foundations right.

1162
01:07:51,800 --> 01:07:53,720
Speaker 2: Well, I look at the people and the health and

1163
01:07:53,720 --> 01:07:57,040
Speaker 2: the body composition of the people selling this, and if

1164
01:07:57,040 --> 01:07:59,560
Speaker 2: they're not healthy, if they're overweight and not in good health,

1165
01:08:00,160 --> 01:08:04,720
Speaker 2: what do I want to emulate what you're doing physition? Yeah,

1166
01:08:05,120 --> 01:08:09,800
Speaker 2: that's right, But here's the solution. Chronic disease is caused

1167
01:08:09,800 --> 01:08:12,680
Speaker 2: by two things, and two things only. Your body is

1168
01:08:12,680 --> 01:08:14,840
Speaker 2: missing something that it needs, or it's exposed to a

1169
01:08:14,880 --> 01:08:17,759
Speaker 2: toxin that it doesn't need. And if we eat whole foods,

1170
01:08:17,840 --> 01:08:22,240
Speaker 2: nutrient dense food and we support healthy digestion and nutrient

1171
01:08:23,400 --> 01:08:29,360
Speaker 2: uptake and assimilation, and we remove from the body toxins, medications, antiseptics,

1172
01:08:30,080 --> 01:08:35,920
Speaker 2: bacterial infections, maybe oral infections, latent viral infections. The body

1173
01:08:36,000 --> 01:08:38,599
Speaker 2: is regenerative by nature. You give the body what it needs,

1174
01:08:38,640 --> 01:08:42,479
Speaker 2: the body heels itself. And so that's the answer. You know,

1175
01:08:42,520 --> 01:08:45,560
Speaker 2: I'm a big proponent of micronutrient analysis to see what's

1176
01:08:45,600 --> 01:08:48,599
Speaker 2: in your diet that's not providing the basic optimal levels

1177
01:08:48,640 --> 01:08:51,360
Speaker 2: of a nutrient and then you can supplement that. Then

1178
01:08:51,400 --> 01:08:55,680
Speaker 2: that makes sense, but it's targeted personalized nutrition. But you know,

1179
01:08:55,680 --> 01:08:57,720
Speaker 2: these people are taking one hundred and fifty pills a day.

1180
01:08:58,320 --> 01:09:00,800
Speaker 2: I mean, I could think of better things to do

1181
01:09:00,840 --> 01:09:03,880
Speaker 2: with that money and better practices to you know, optimize

1182
01:09:03,920 --> 01:09:09,000
Speaker 2: the human body, eat good whole foods and exercise minutes

1183
01:09:09,040 --> 01:09:09,920
Speaker 2: and brick sunlighted in.

1184
01:09:12,720 --> 01:09:17,160
Speaker 1: Out reigious claims that you're making to do the ship right,

1185
01:09:17,439 --> 01:09:19,920
Speaker 1: because I mean, I think the other thing is that

1186
01:09:20,320 --> 01:09:22,400
Speaker 1: when people are spending so much money in all these

1187
01:09:22,400 --> 01:09:25,200
Speaker 1: different supplements, they don't know how they interact with each other.

1188
01:09:25,680 --> 01:09:28,240
Speaker 1: They don't know the right timing. You know, as you

1189
01:09:28,280 --> 01:09:31,680
Speaker 1: said earlier on I remember you talked about the harvest

1190
01:09:32,479 --> 01:09:35,640
Speaker 1: at the time of the harvest. I've seen research that

1191
01:09:35,760 --> 01:09:40,400
Speaker 1: the time of the harvest massively influences the activity of

1192
01:09:40,439 --> 01:09:44,599
Speaker 1: a particular supplement. Right, So we just and there's all

1193
01:09:44,640 --> 01:09:49,120
Speaker 1: sorts of companies grandfathering off research of other companies that

1194
01:09:49,240 --> 01:09:51,639
Speaker 1: are producing a really good molecule and then they're doing

1195
01:09:51,720 --> 01:09:56,080
Speaker 1: a shitty cheap version of it that people are taking

1196
01:09:56,120 --> 01:09:58,760
Speaker 1: and just not knowing whether this is actually having an

1197
01:09:58,760 --> 01:10:02,120
Speaker 1: effect and how it's interact Well.

1198
01:10:02,120 --> 01:10:04,479
Speaker 2: The other problem is a study published I think last

1199
01:10:04,560 --> 01:10:07,400
Speaker 2: year maybe early this year, a third party company went

1200
01:10:07,400 --> 01:10:12,000
Speaker 2: in and bought supplements off the shelf that supplements stores

1201
01:10:12,040 --> 01:10:16,000
Speaker 2: and you know, pharmacies analyze it in seventy something percent

1202
01:10:16,120 --> 01:10:18,960
Speaker 2: of the products they tested didn't even have what was

1203
01:10:18,960 --> 01:10:19,519
Speaker 2: on the label.

1204
01:10:19,800 --> 01:10:21,080
Speaker 1: Fucking yeah, it's crazy.

1205
01:10:21,160 --> 01:10:23,080
Speaker 2: I mean it's the wild wild West. And then you

1206
01:10:23,080 --> 01:10:25,280
Speaker 2: know it's even worse than the nitrocoxide field. And going

1207
01:10:25,280 --> 01:10:27,439
Speaker 2: back to when we opened this up, you know beats

1208
01:10:28,040 --> 01:10:30,160
Speaker 2: ninety nine percent of the beat products on the market

1209
01:10:30,200 --> 01:10:32,280
Speaker 2: provides zero nitric oxide benefit.

1210
01:10:32,600 --> 01:10:33,599
Speaker 1: Is that right?

1211
01:10:34,160 --> 01:10:34,479
Speaker 4: That's right.

1212
01:10:34,520 --> 01:10:36,559
Speaker 2: I've tested all these In fact, we use them as

1213
01:10:36,560 --> 01:10:41,040
Speaker 2: placebos and our randomized placebo control clinical trials. All they

1214
01:10:41,080 --> 01:10:43,160
Speaker 2: do is turn your pee and your poop pink. There

1215
01:10:43,240 --> 01:10:46,719
Speaker 2: is no nitrocoxide benefit to them. Because again, think about

1216
01:10:47,040 --> 01:10:49,599
Speaker 2: and most of these companies buying the cheapest beat powder

1217
01:10:50,200 --> 01:10:53,439
Speaker 2: out there to put in a castle. And I'm gonna

1218
01:10:53,439 --> 01:10:56,320
Speaker 2: take it through the math. The highest concentration of beats

1219
01:10:56,400 --> 01:10:59,120
Speaker 2: that's on the market that you can actually get from

1220
01:10:59,200 --> 01:11:03,479
Speaker 2: the field is about six to nine percent nitree. So

1221
01:11:03,479 --> 01:11:07,880
Speaker 2: if you've got say one gram of beat powder, then

1222
01:11:07,960 --> 01:11:10,200
Speaker 2: only about six to nine percent is going to be nitrite.

1223
01:11:10,240 --> 01:11:13,200
Speaker 2: You need three hundred to four hundred milligrams of nitrate,

1224
01:11:13,320 --> 01:11:16,080
Speaker 2: so that means you would need five to six grams

1225
01:11:16,880 --> 01:11:20,599
Speaker 2: of that highly concentrated beat powder to get sufficient amounts

1226
01:11:20,640 --> 01:11:25,400
Speaker 2: of nitrate to fuel microcoxite. A capsule is seven hundred milligrams,

1227
01:11:25,439 --> 01:11:27,400
Speaker 2: and they're saying, oh, take one or two capsules of

1228
01:11:27,439 --> 01:11:28,080
Speaker 2: this beet powder.

1229
01:11:29,120 --> 01:11:30,960
Speaker 1: The math work, Yeah and two.

1230
01:11:31,600 --> 01:11:34,000
Speaker 2: Most of these beat powders don't even contain any nitrate

1231
01:11:34,080 --> 01:11:37,000
Speaker 2: because when they take the high bricks concentrate that comes

1232
01:11:37,000 --> 01:11:38,960
Speaker 2: from the manufacturer, then they make it into a powder.

1233
01:11:39,680 --> 01:11:42,519
Speaker 2: It's a high heat, high pressure system. These are water

1234
01:11:42,600 --> 01:11:45,599
Speaker 2: soluble nutrients that come out. There's nothing left in the powder.

1235
01:11:46,320 --> 01:11:48,680
Speaker 2: It's just beat fiber with a lot of oxillates that

1236
01:11:48,720 --> 01:11:49,679
Speaker 2: cause kidney stones.

1237
01:11:50,040 --> 01:11:56,559
Speaker 1: It's just expansive pests. Basically beat this at that. It's

1238
01:11:56,640 --> 01:12:00,800
Speaker 1: pretty expensive fists.

1239
01:12:01,080 --> 01:12:02,120
Speaker 2: I guess.

1240
01:12:02,240 --> 01:12:06,599
Speaker 1: So, Nathan, what are you excited about for the next

1241
01:12:06,720 --> 01:12:10,519
Speaker 1: sort of ten or twenty years in this space and

1242
01:12:10,720 --> 01:12:13,679
Speaker 1: in the general bio hiking space.

1243
01:12:14,800 --> 01:12:16,960
Speaker 2: Well, look, I've been in academ I spent twenty five

1244
01:12:17,000 --> 01:12:19,799
Speaker 2: years in academ and it wasn't my objective to develop

1245
01:12:20,040 --> 01:12:23,320
Speaker 2: dietary supplements. My objective was to understand the mechanism of

1246
01:12:23,360 --> 01:12:26,120
Speaker 2: disease to the extent that we could develop drug therapy

1247
01:12:26,760 --> 01:12:30,679
Speaker 2: and actually show safe and effective nitrocoxide product technology. Obviously,

1248
01:12:30,720 --> 01:12:33,479
Speaker 2: we make dietary supplements. We've been very successful. We make

1249
01:12:33,520 --> 01:12:36,640
Speaker 2: topical nitrocoxide products for skin care and beauty. But what

1250
01:12:36,760 --> 01:12:39,200
Speaker 2: still gets me up in the morning is our drug

1251
01:12:39,240 --> 01:12:42,320
Speaker 2: discovery program. We've got drugs we're about to put through

1252
01:12:42,320 --> 01:12:45,640
Speaker 2: the FDA for a schemic card disease. These are vasodilators.

1253
01:12:45,640 --> 01:12:48,040
Speaker 2: They dilate the cornery artis and patients with the schemic

1254
01:12:48,080 --> 01:12:51,799
Speaker 2: card disease. We're going to start that clinical trial probably

1255
01:12:51,840 --> 01:12:54,679
Speaker 2: early next year. We've got a drug where we're making

1256
01:12:54,720 --> 01:12:58,559
Speaker 2: for Alzheimer's. I think nitrocoxide drug therapy will completely eradicate

1257
01:12:58,560 --> 01:13:03,719
Speaker 2: Alzheimer's because it addresses the vascular and metabolic root cause

1258
01:13:04,040 --> 01:13:07,840
Speaker 2: of dimension Alzheimer's. As as I mentioned, it's a vasodilator.

1259
01:13:07,880 --> 01:13:10,760
Speaker 2: It's going to improve oxygenation of the blood. It's gonna

1260
01:13:10,760 --> 01:13:14,040
Speaker 2: get insulin into the brain. Alzheimer's is what we call

1261
01:13:14,120 --> 01:13:16,360
Speaker 2: diabetes type three. Yes in resistance.

1262
01:13:16,520 --> 01:13:16,840
Speaker 1: Yes.

1263
01:13:17,120 --> 01:13:19,640
Speaker 2: If we give nitrocoxide, we dilate the blood vessels, we

1264
01:13:19,680 --> 01:13:23,200
Speaker 2: perfuse the brain, We improve insulin sensitivity. When you don't

1265
01:13:23,240 --> 01:13:25,400
Speaker 2: do When you do that, you don't get misfolding of

1266
01:13:25,439 --> 01:13:27,880
Speaker 2: proteins and there's no tall tangles, there's no amloid plaque

1267
01:13:27,920 --> 01:13:31,920
Speaker 2: and people maintain memory and cognition. It's root cause medicine,

1268
01:13:32,520 --> 01:13:34,839
Speaker 2: and then we have a topical drug for diabetic ulcers

1269
01:13:34,840 --> 01:13:39,360
Speaker 2: and non healing wounds. You know, sixty five thousand Americans

1270
01:13:39,400 --> 01:13:41,639
Speaker 2: die in nursing homes every year from wounds that get

1271
01:13:41,680 --> 01:13:45,400
Speaker 2: infected and divecepsis not to mention the number of diabetic

1272
01:13:45,439 --> 01:13:48,720
Speaker 2: wounds and diabetic foot ulcers and non healing wounds. I mean,

1273
01:13:48,800 --> 01:13:52,360
Speaker 2: nitrocoxide gets blood float to the wound, it kills the

1274
01:13:52,360 --> 01:13:55,160
Speaker 2: infection that's in the wound, and the wound heals itself.

1275
01:13:55,200 --> 01:13:57,640
Speaker 2: We've not seen a wound that our nitrocoxide hasn't been

1276
01:13:57,680 --> 01:13:58,080
Speaker 2: able to heal.

1277
01:13:58,920 --> 01:14:02,160
Speaker 1: I'm going to buy it's the nitchek oxide on the wound.

1278
01:14:02,200 --> 01:14:05,320
Speaker 1: What about red light, because I know red light is

1279
01:14:05,360 --> 01:14:08,519
Speaker 1: good for wound healing, it's good for burns. Would that

1280
01:14:08,640 --> 01:14:13,320
Speaker 1: potentiate the nitchic oxide or have a synergistic effect? It would?

1281
01:14:13,400 --> 01:14:15,320
Speaker 2: In fact, you know, I came up with this concept

1282
01:14:15,360 --> 01:14:17,479
Speaker 2: from treating my dad. My dad's a peer pelegic from

1283
01:14:17,479 --> 01:14:19,679
Speaker 2: a car accident he had nineteen eighty four. Dad's seventy

1284
01:14:19,840 --> 01:14:22,040
Speaker 2: six years old today. But he's been rolling around in

1285
01:14:22,040 --> 01:14:24,360
Speaker 2: a wheelchair for forty something years. But you know, developed

1286
01:14:24,360 --> 01:14:27,280
Speaker 2: pressure ulcers to keep the sorcers. In twenty fourteen, he

1287
01:14:27,360 --> 01:14:32,880
Speaker 2: had a non healing osteolocrotic osteomylitis stage four wound that

1288
01:14:32,920 --> 01:14:35,000
Speaker 2: wouldn't heal and he almost died from it, got infected

1289
01:14:35,000 --> 01:14:35,960
Speaker 2: and became sipted.

1290
01:14:36,400 --> 01:14:36,679
Speaker 1: Wow.

1291
01:14:36,720 --> 01:14:38,719
Speaker 2: So the other wound care docs told me we would

1292
01:14:38,720 --> 01:14:40,800
Speaker 2: never heal this wound on a sixty five year old

1293
01:14:40,840 --> 01:14:44,599
Speaker 2: peer polegic diabetic patient, and I just refused to accept that.

1294
01:14:44,680 --> 01:14:49,439
Speaker 2: So that's when I started looking into developing a topical

1295
01:14:49,520 --> 01:14:51,680
Speaker 2: nitric oxide that I could put into the wound bed

1296
01:14:52,400 --> 01:14:54,400
Speaker 2: and I could see tissue growth, I could see the

1297
01:14:54,439 --> 01:14:57,800
Speaker 2: tissue granulation. I could see that kind of gray, kind

1298
01:14:57,840 --> 01:15:01,880
Speaker 2: of discolored wound bed turned bright pink. But just to

1299
01:15:01,960 --> 01:15:04,200
Speaker 2: your question, I actually used red light on it too.

1300
01:15:04,800 --> 01:15:06,960
Speaker 2: So I put the nitric oxide wound dressing in there,

1301
01:15:07,000 --> 01:15:09,280
Speaker 2: and then I would shine red light on it. And

1302
01:15:09,320 --> 01:15:11,599
Speaker 2: I did also did ozone to kind of killed the infection.

1303
01:15:11,720 --> 01:15:13,600
Speaker 2: But I did a number of things. But you know,

1304
01:15:13,640 --> 01:15:15,360
Speaker 2: we healed that four year old, non healing wound in

1305
01:15:15,400 --> 01:15:16,639
Speaker 2: eight months. Wow.

1306
01:15:17,120 --> 01:15:21,200
Speaker 1: Wow, that's pretty amazing. Just while I have you one

1307
01:15:21,720 --> 01:15:26,400
Speaker 1: last question, and just because you mentioned Alzheimer's disease and

1308
01:15:27,479 --> 01:15:31,840
Speaker 1: I'm totally on board with the whole nitric oxide. What's

1309
01:15:31,880 --> 01:15:35,600
Speaker 1: your take on the recent study about lithium or a

1310
01:15:35,680 --> 01:15:39,360
Speaker 1: tate and Ali you have you seen that study and

1311
01:15:39,439 --> 01:15:40,920
Speaker 1: do you have any thoughts on it?

1312
01:15:42,760 --> 01:15:44,840
Speaker 2: I think lithium is one of Look, it's an element.

1313
01:15:44,880 --> 01:15:47,360
Speaker 2: It's number seven on the periodic table. Was the original

1314
01:15:47,360 --> 01:15:49,519
Speaker 2: development of seven up? You know seven up was rich.

1315
01:15:51,520 --> 01:15:54,280
Speaker 2: That's really but no, I think it's a it's a

1316
01:15:54,400 --> 01:15:58,160
Speaker 2: nutrient or mineral that's missing in some people. Mechanistically, I'm

1317
01:15:58,200 --> 01:16:02,559
Speaker 2: not sure how it's affecting Alzheimer's and neurotransmission, but you know,

1318
01:16:02,600 --> 01:16:04,519
Speaker 2: the data or the data and it seemed to get better.

1319
01:16:04,600 --> 01:16:08,600
Speaker 2: You know. I started experimenting myself with taking low dose lithium,

1320
01:16:08,640 --> 01:16:11,280
Speaker 2: and so I take about twenty five milligrams of lithium

1321
01:16:11,360 --> 01:16:15,080
Speaker 2: ortate a day. When I first started, probably six or

1322
01:16:15,080 --> 01:16:17,360
Speaker 2: eight months ago, I took it in the afternoon. I mean,

1323
01:16:17,560 --> 01:16:20,280
Speaker 2: my brain was firing and I had trouble sleeping, and

1324
01:16:20,280 --> 01:16:22,240
Speaker 2: then I took it that morning when I woke up.

1325
01:16:22,320 --> 01:16:24,400
Speaker 2: And you know, it's just part of my daily regiment

1326
01:16:24,479 --> 01:16:26,920
Speaker 2: now because I felt the difference of that and things

1327
01:16:26,920 --> 01:16:28,880
Speaker 2: that I feel the difference when I'm in tune with

1328
01:16:29,320 --> 01:16:31,240
Speaker 2: what I'm doing. So you know, I actually give it

1329
01:16:31,280 --> 01:16:35,679
Speaker 2: to my dad who has kind of Parkinsonium type tremors,

1330
01:16:35,680 --> 01:16:41,960
Speaker 2: not Parkinson's disease, but it's helped him. It's helped is cognition.

1331
01:16:42,280 --> 01:16:44,760
Speaker 2: So I've seen I've seen it, waitness it personally end

1332
01:16:44,800 --> 01:16:45,400
Speaker 2: with my family.

1333
01:16:46,040 --> 01:16:49,599
Speaker 1: Yeah. Interesting, do you take creating just start of interest?

1334
01:16:49,840 --> 01:16:52,760
Speaker 2: I do take creating before my workouts in the morning. Yeah,

1335
01:16:52,800 --> 01:16:54,880
Speaker 2: just started that probably maybe three or four months ago,

1336
01:16:54,920 --> 01:16:58,520
Speaker 2: because again, the data coming out on creating to mention Alzheimer's,

1337
01:16:59,280 --> 01:17:01,559
Speaker 2: the science, Yeah, and mood.

1338
01:17:01,640 --> 01:17:03,719
Speaker 1: I mean, I mean, geez, we've known for decades about

1339
01:17:03,760 --> 01:17:06,439
Speaker 1: its benefits in terms of exercise, but I guess it's

1340
01:17:06,479 --> 01:17:08,879
Speaker 1: one of those things that when I saw the impact

1341
01:17:08,880 --> 01:17:12,000
Speaker 1: on brain health and on mood, and you kind of go, actually,

1342
01:17:12,040 --> 01:17:14,920
Speaker 1: when you think about the biochemistry, it freaking makes sense,

1343
01:17:15,000 --> 01:17:20,680
Speaker 1: doesn't it? ATPPC right, and it's deep and effective. This

1344
01:17:20,720 --> 01:17:25,320
Speaker 1: has been bloody awesome. I've thoroughly enjoyed this, and I'm

1345
01:17:25,360 --> 01:17:28,200
Speaker 1: sure my listeners will all have enjoyed it. And now work.

1346
01:17:28,280 --> 01:17:30,719
Speaker 1: Can they go to find out more about your work

1347
01:17:30,880 --> 01:17:33,400
Speaker 1: and tell us about your book and tell us about

1348
01:17:33,800 --> 01:17:35,559
Speaker 1: and you know what made you want to write the

1349
01:17:35,560 --> 01:17:38,400
Speaker 1: book and where can they get it? Just give us

1350
01:17:38,600 --> 01:17:40,280
Speaker 1: a bit of an overview of the book and all

1351
01:17:40,320 --> 01:17:41,120
Speaker 1: the stuff that you do.

1352
01:17:41,920 --> 01:17:43,680
Speaker 2: Well, you know, I give thirty or forty lectures a

1353
01:17:43,760 --> 01:17:46,719
Speaker 2: year all around the world, and you know the audience

1354
01:17:46,760 --> 01:17:51,080
Speaker 2: is typically mesmerized and really excited about the future of nitrocoxide.

1355
01:17:51,120 --> 01:17:54,160
Speaker 2: And you know these are typically physicians, and you know,

1356
01:17:54,280 --> 01:17:56,479
Speaker 2: consumers need to know about this. So my motivation for

1357
01:17:56,520 --> 01:17:59,720
Speaker 2: writing the book was to tell the entire story of nitrocoxide,

1358
01:17:59,760 --> 01:18:02,800
Speaker 2: how discovered, what led to a Nobel prize, and what

1359
01:18:02,840 --> 01:18:04,880
Speaker 2: it does in the body way everybody should be concerned

1360
01:18:04,920 --> 01:18:08,080
Speaker 2: about it. But I also integrate in that book my

1361
01:18:08,120 --> 01:18:11,599
Speaker 2: own personal journey of discovery, kind of my background, my education,

1362
01:18:11,760 --> 01:18:13,800
Speaker 2: and how we were able to see what everyone else

1363
01:18:13,800 --> 01:18:15,559
Speaker 2: has seen, but to think what no one else has thought.

1364
01:18:15,600 --> 01:18:18,679
Speaker 2: So the book is really it's a must read. Obviously

1365
01:18:18,680 --> 01:18:22,280
Speaker 2: have a very strong personal bias, but it's It's nathan'sbook.

1366
01:18:22,320 --> 01:18:24,559
Speaker 2: Dot com and get an Amazon, Barnes, Noble, wherever books

1367
01:18:24,560 --> 01:18:27,760
Speaker 2: are sold. I must read the Secret of Nitrocoxide, Bring

1368
01:18:27,800 --> 01:18:30,400
Speaker 2: the Science to Life. I have a copy here that

1369
01:18:30,479 --> 01:18:36,439
Speaker 2: we just this is in portug translated. That's the only

1370
01:18:36,560 --> 01:18:39,200
Speaker 2: version I have with me, but it's called the Secret

1371
01:18:39,200 --> 01:18:41,479
Speaker 2: of nitric Oxide Bring the Science to Life. I've got

1372
01:18:41,520 --> 01:18:47,160
Speaker 2: a YouTube channel providing education, real science, real information, real

1373
01:18:47,200 --> 01:18:50,400
Speaker 2: knowledge on nitrocoxide to kind of, you know, filter through

1374
01:18:50,439 --> 01:18:53,599
Speaker 2: the misinformation all the myths out there. That's doctor Nathan

1375
01:18:53,680 --> 01:18:57,559
Speaker 2: s Brian Nitrocoxide. I'm on Instagram, doctor Nathan s Brian,

1376
01:18:58,040 --> 01:19:03,759
Speaker 2: LinkedIn Twitter, doctor Nittrick. See I'm searchable my most search engines.

1377
01:19:03,920 --> 01:19:07,880
Speaker 1: Wow, you certainly are. And so Nathan, look, this has

1378
01:19:07,880 --> 01:19:11,120
Speaker 1: been bloody awesome. I will certainly be diving into the

1379
01:19:11,120 --> 01:19:14,400
Speaker 1: book and and going onto your YouTube channel because, like

1380
01:19:14,439 --> 01:19:18,360
Speaker 1: you said earlier, there's so many influencers out there that

1381
01:19:18,439 --> 01:19:23,559
Speaker 1: have got no frigging background in terms of the education

1382
01:19:23,600 --> 01:19:26,080
Speaker 1: and what they're talking about. But but but you, with

1383
01:19:26,320 --> 01:19:31,360
Speaker 1: your deep research in physiology and biochemistry, I think, really

1384
01:19:31,439 --> 01:19:35,400
Speaker 1: understand the body and are and can communicate it very well,

1385
01:19:35,400 --> 01:19:38,599
Speaker 1: which is a rare skill. So thank you for everything

1386
01:19:38,720 --> 01:19:41,799
Speaker 1: you do and and keep on being a trail blazer

1387
01:19:41,880 --> 01:19:45,120
Speaker 1: and an explorer and seeing what everybody else is seeing

1388
01:19:45,120 --> 01:19:47,240
Speaker 1: but thinking differently. That's fregaging awesome.

1389
01:19:47,520 --> 01:19:54,120
Speaker 2: Thank you very much, Thank you, With you,