WEBVTT - #1966 Migraines, Seed Oils, And Profit - David Gillespie 0:00:01.280 --> 0:00:04.560 I get at it's you project, it's gals Bow, it's cook, Oh, 0:00:04.559 --> 0:00:09.200 it's harp so and it's another day on the typ journey. 0:00:09.240 --> 0:00:13.000 We're rocketing. We're rocketing towards two thousand episodes. If you've 0:00:13.039 --> 0:00:15.000 got an idea what we might do for the two 0:00:15.040 --> 0:00:19.400 thousandth t if I was thinking of maybe doing a 0:00:19.440 --> 0:00:24.160 live episode with like fifty people or something live recorded 0:00:24.200 --> 0:00:26.119 live with people asking what are you looking at me 0:00:26.239 --> 0:00:27.720 like that? For? Is that a bad idea? 0:00:27.880 --> 0:00:30.760 What do you mean fifty people, fifty people watching? 0:00:31.040 --> 0:00:32.720 Not for me? No, no, no, I mean like a live 0:00:32.840 --> 0:00:35.200 zoom call where fifty people can sit in the zoom 0:00:35.600 --> 0:00:38.280 room like we're doing right now with Golespo, but another 0:00:38.360 --> 0:00:39.960 fifty vagabonds. 0:00:40.080 --> 0:00:41.640 Oh that would be so fun. 0:00:42.200 --> 0:00:44.800 Who can sit in, you know, on mute and then 0:00:44.840 --> 0:00:48.200 at a given time ask questions, either type questions through 0:00:48.320 --> 0:00:51.080 or ask verbally turning on the old mic. 0:00:51.440 --> 0:00:53.159 But how do you pick the fifty? 0:00:54.520 --> 0:00:56.880 Well, it's whoever sends us one thousand dollars in small 0:00:57.000 --> 0:00:59.480 unmarked bills to No, I don't know, I don't know. 0:00:59.520 --> 0:01:03.639 I haven't thought it through. Well, see here's the problem too. 0:01:03.640 --> 0:01:07.320 When you do stuff like that, sometimes people go yeah, yeah, yeah, 0:01:07.319 --> 0:01:08.600 then they don't show right. 0:01:08.680 --> 0:01:11.399 Yeah, and soon they've all got to type stuff in. 0:01:11.440 --> 0:01:13.560 I was like, that sounds way more like a Melissa 0:01:13.680 --> 0:01:16.960 level of attention to detail than a Tiff Cook. 0:01:17.560 --> 0:01:20.280 No, no, no, it's like you can type right now 0:01:20.319 --> 0:01:23.160 in the old chat you can write, hey, harps, get 0:01:23.200 --> 0:01:26.000 closer to the microphone that never works. 0:01:26.080 --> 0:01:26.920 You never listen to that. 0:01:27.840 --> 0:01:30.120 I don't read it and I don't listen to you anyway. Calls. 0:01:30.160 --> 0:01:31.440 But what do you think we should do for a 0:01:31.600 --> 0:01:33.880 thousandth two thousandth? 0:01:34.560 --> 0:01:39.479 I don't know. I have very little experience with such things. 0:01:39.680 --> 0:01:44.560 So yeah, it's not often you can catch him out 0:01:44.600 --> 0:01:45.160 to your visit. 0:01:45.959 --> 0:01:49.200 Absolutely no idea. Have you tried asking Ai? 0:01:50.640 --> 0:01:54.280 Yeah? Well maybe I asked a tipple to it right now? 0:01:54.560 --> 0:01:58.200 If asking Ai, what should a podcast do for the 0:01:58.360 --> 0:02:00.320 two thousand episode? 0:02:00.720 --> 0:02:03.360 Have you got any ideas too? Yeah? 0:02:03.840 --> 0:02:04.760 See what it comes up with. 0:02:07.320 --> 0:02:09.799 Oh I just drank some water. Very bad protocol on 0:02:09.840 --> 0:02:13.520 the bloody podcast. But who cares? Well whilst she's doing that, 0:02:13.600 --> 0:02:15.800 you put up your hand when you've got that. But GILESPO, 0:02:17.120 --> 0:02:20.160 welcome back. Thank you so much for joining us as 0:02:20.240 --> 0:02:26.280 you do once fortnite. Just so you know David's I 0:02:26.320 --> 0:02:27.680 don't know what would you call it? What do you 0:02:27.720 --> 0:02:28.720 call raisin Hell? 0:02:28.960 --> 0:02:29.200 Is that? 0:02:29.240 --> 0:02:32.600 What just were your I was going to say suppository. 0:02:33.320 --> 0:02:34.920 What I meant was repository. 0:02:34.960 --> 0:02:35.600 Repository. 0:02:35.720 --> 0:02:42.640 Yes, yeah, David's suppository of quality work. No, his repository 0:02:42.639 --> 0:02:46.760 of articles. Is Is it raisinhell dot com? 0:02:46.840 --> 0:02:49.120 Is it on? No? No, it's just on substack and 0:02:49.600 --> 0:02:54.239 in search for which search for raisin Hell on substack. 0:02:54.680 --> 0:02:58.760 And that is R A I S I N hble 0:02:58.960 --> 0:03:02.200 l if have you got any gold for us? Have 0:03:02.280 --> 0:03:03.640 you got any wisdom? 0:03:04.040 --> 0:03:04.560 The reverse? 0:03:04.680 --> 0:03:06.320 The creative Genius. 0:03:06.120 --> 0:03:09.960 Flip the mic two thousand and two thousand, Rapid Fire 0:03:10.000 --> 0:03:13.440 Wisdom two thousand seconds, where you give your twenty most 0:03:13.480 --> 0:03:18.440 powerful lessons from two thousand episodes. Audience in the room 0:03:20.520 --> 0:03:21.600 many a bit mare. 0:03:22.680 --> 0:03:24.160 Maybe you need to Maybe you need to give it 0:03:24.200 --> 0:03:26.200 a bit more context iff and tell it what the 0:03:26.240 --> 0:03:28.080 show is about. It might be able to do better. 0:03:28.560 --> 0:03:31.520 Chatters knows everything about my life, man. Chatters are best mates. 0:03:31.560 --> 0:03:31.679 You know. 0:03:32.040 --> 0:03:33.359 Chatters knows all about heart. 0:03:34.120 --> 0:03:36.800 That's true. If I asked my Chatters, it would say 0:03:36.800 --> 0:03:39.360 something different because it and my are besties. Although we 0:03:39.360 --> 0:03:40.000 did have a fight. 0:03:40.040 --> 0:03:43.640 The other day, Oh, harps in the hot seat, the 0:03:43.760 --> 0:03:46.240 uncensored roast and therapy session. 0:03:46.320 --> 0:03:47.080 There we go. 0:03:47.920 --> 0:03:52.880 Don't need you, Yeah, we don't need that. Already got 0:03:52.960 --> 0:03:57.640 enough issues. I'm already in therapy three times a week. 0:03:57.640 --> 0:04:01.920 All right, gillespo, welcome back to the show. As I said, 0:04:02.000 --> 0:04:05.960 so you wrote an article. There was a new one 0:04:05.960 --> 0:04:08.160 out today which I haven't read yet, apologize, but you 0:04:08.200 --> 0:04:10.720 wrote one about a week ago, I would think now 0:04:10.760 --> 0:04:15.040 called Engineered for Pain, the Untold Story of Migraine, seed, 0:04:15.080 --> 0:04:19.800 oils and profit. And yeah, that's a really good article. Everyone, 0:04:19.839 --> 0:04:21.479 if you want to go, have a read of it. 0:04:21.560 --> 0:04:23.640 But if you can't be bothered, just tune in right 0:04:23.680 --> 0:04:25.360 now because the Great Man is going to give us 0:04:25.839 --> 0:04:28.800 a little bit of a reader's digest version of what 0:04:28.839 --> 0:04:29.440 that was about. 0:04:30.360 --> 0:04:34.080 So have you have you ever suffered from migraine? Set all? 0:04:35.120 --> 0:04:37.720 I have. I've been very lucky. I don't know why, 0:04:37.760 --> 0:04:43.200 but yeah, I do have friends who absolutely crippled by them. 0:04:43.360 --> 0:04:45.480 And yeah, hole got to be in a dark room, 0:04:46.360 --> 0:04:51.120 eyes closed, no noise, no movement. Yeah, so it's I 0:04:51.160 --> 0:04:54.200 personally can't understand, but I've been around it very debility. 0:04:54.320 --> 0:04:56.240 Yeah, I've been around it quite a bit, because my 0:04:56.279 --> 0:05:00.240 wife has had them at quite bad at time in 0:05:00.240 --> 0:05:03.200 her life, and some of my kids have as well. 0:05:03.760 --> 0:05:06.000 If you ever had migraines. 0:05:05.640 --> 0:05:09.000 Yeah, I got them monthly when I hit adolescents for 0:05:09.080 --> 0:05:11.960 a period of time was horrible. 0:05:12.680 --> 0:05:14.400 There's a good reason for that, and we're going to 0:05:14.440 --> 0:05:15.480 talk about that a little bit. 0:05:16.480 --> 0:05:18.800 How long did they last? How long? Sorry, David, how 0:05:18.839 --> 0:05:19.679 long did they last? 0:05:19.920 --> 0:05:23.800 They were brutal. They were usually just twenty four hours, 0:05:23.800 --> 0:05:28.000 but I would vomit like literally every hour on the hour, 0:05:28.200 --> 0:05:31.120 and then that would just slowly pit her out longer 0:05:31.160 --> 0:05:31.599 and longer. 0:05:31.640 --> 0:05:32.640 It was. 0:05:32.640 --> 0:05:34.680 Was it exactly when you got your period or was 0:05:34.720 --> 0:05:35.880 it just during that time? 0:05:36.440 --> 0:05:38.520 It was the few months before it was leading up 0:05:38.560 --> 0:05:41.000 to that time, because but I remember the school, my 0:05:41.040 --> 0:05:43.480 school teacher, one of my school teachers. I kept going 0:05:43.480 --> 0:05:46.960 home once a month and they said then they just 0:05:47.000 --> 0:05:48.919 started asking me if you got your period yet? I 0:05:48.920 --> 0:05:50.200 think this might be hormonal. 0:05:51.480 --> 0:05:55.600 Yeah, it was horrible, horr Right, So when you got 0:05:55.600 --> 0:05:56.760 your period that stopped? 0:05:57.200 --> 0:05:57.599 Yeah? 0:05:58.000 --> 0:06:02.440 Yeah, oh yeah, it is interesting. We might talk a 0:06:02.480 --> 0:06:07.200 little bit about why that might be. But let's migrains 0:06:07.200 --> 0:06:10.080 affect an awful lot of people, and they aren't just 0:06:10.240 --> 0:06:15.880 headaches there, you know, as Tiff described, really crippling can 0:06:15.920 --> 0:06:18.480 be for sort of up to twenty four hours, and 0:06:18.600 --> 0:06:21.799 they can be multiple times a month. I mean TIFFs 0:06:21.960 --> 0:06:25.159 were just once a month. But people can who suffer 0:06:25.200 --> 0:06:28.120 from this, and it is a lot of people. You know, 0:06:28.600 --> 0:06:32.080 it is debilitating and you know it can affect their career, 0:06:32.160 --> 0:06:34.120 can affect their job because it just can't work. You 0:06:34.160 --> 0:06:38.159 can't go to work, you know, you can't look after kids, 0:06:38.200 --> 0:06:42.320 you can't do anything. And so it's been, as you 0:06:42.400 --> 0:06:45.480 might imagine, a bit of a priority for the drug 0:06:45.520 --> 0:06:47.760 makers to come up with something that they can do 0:06:47.800 --> 0:06:53.000 about it, because you know, panodole and neurophin and so 0:06:53.080 --> 0:06:55.560 on just aren't going to do anything for you. If 0:06:55.600 --> 0:06:59.720 you would have experienced that taking a couple of panadol 0:06:59.720 --> 0:07:01.760 would done much for your migraine. It's just something you 0:07:01.800 --> 0:07:07.200 have to work through, right ye. Yeah. And there's a 0:07:07.200 --> 0:07:09.159 good reason for it, because there's a lot more going 0:07:09.200 --> 0:07:11.920 on than just a headache. The headache sort of the 0:07:11.960 --> 0:07:15.720 final bit of what's going on. It starts with what 0:07:15.760 --> 0:07:20.520 they call, you know, sort of a spreading well, well 0:07:20.520 --> 0:07:23.840 they call it a CSDE or cortical spreading depression, which 0:07:23.880 --> 0:07:27.000 is just a wave of electrical activity in the brain, 0:07:27.200 --> 0:07:29.920 which often is what causes the aura that a lot 0:07:29.920 --> 0:07:33.760 of people describe. So they get an aura before the 0:07:33.800 --> 0:07:36.680 pain where you know, and they know it's coming, so 0:07:36.720 --> 0:07:39.040 that it's not yet hurting, but they know it's about 0:07:39.040 --> 0:07:43.520 to hit, and that probably makes it even scarier. But 0:07:43.560 --> 0:07:45.960 I guess it gives them warning to get into a 0:07:46.040 --> 0:07:48.960 dark room, calm down, stay out of the way of 0:07:49.080 --> 0:07:53.680 noise and light and so on. But what's going on 0:07:53.760 --> 0:07:58.360 in a migraine has probably since the early nineties started 0:07:58.360 --> 0:08:01.160 to be a lot clearer since they discovered some of 0:08:01.200 --> 0:08:04.360 the peptides that were involved in the brain, and in 0:08:04.360 --> 0:08:09.560 particular one called CGRP, which I won't bother digging out. 0:08:09.600 --> 0:08:11.720 People can read the articles that are interested in it. 0:08:11.760 --> 0:08:15.600 But CGRP is important because the drug companies have found 0:08:16.120 --> 0:08:20.560 that they can suppress the impact of CGRP. So CGRP 0:08:20.680 --> 0:08:25.760 seems to be critically involved in the pain mechanism, so 0:08:25.800 --> 0:08:29.880 the spreading pain inside the brain, So just to be 0:08:30.440 --> 0:08:34.600 sure to be clear on what's going on, CGRP is 0:08:34.640 --> 0:08:39.640 what's known as a vasodilator, so it dilates the veins 0:08:40.480 --> 0:08:43.120 the blood vessels in the brain, particularly around the edge 0:08:43.120 --> 0:08:49.480 of the brain the Meninji's and widens and causes the throbbing, 0:08:49.559 --> 0:08:56.400 pulsating pain that's associated with migraines. Now, the drug companies, 0:08:56.600 --> 0:08:58.839 as soon as they found that, started working on are 0:08:58.880 --> 0:09:03.400 there things we can do to block CGRP, like, you know, 0:09:03.920 --> 0:09:06.640 can we interfere with the receptors for CGRP and the brain, 0:09:06.679 --> 0:09:08.920 et cetera, et cetera. Working on a lot. In the 0:09:09.000 --> 0:09:12.840 last decade or so, some powerful drugs have come out 0:09:13.600 --> 0:09:21.440 which do exactly that. So those drugs actually counteract CGRP 0:09:21.600 --> 0:09:26.320 in the brain and the result is that people who 0:09:26.360 --> 0:09:32.120 are given these drugs experience two to two and a 0:09:32.200 --> 0:09:37.000 half less migraine days per month, which is a significant impact. 0:09:37.080 --> 0:09:41.720 It's way beyond anything you know, anyone's ever managed before 0:09:41.720 --> 0:09:43.880 with any sort of standard pain killer, because it's not 0:09:43.960 --> 0:09:49.679 actually a painkiller, it's it's targeting the exact cares and 0:09:49.720 --> 0:09:53.800 so for that reason, it's powerful. It works. We know 0:09:53.880 --> 0:09:58.199 it works, and these drugs are now obviously finding themselves 0:09:58.400 --> 0:10:02.320 a very very big mark because this is something that impacts, 0:10:02.760 --> 0:10:07.040 you know, large percentages of the workforce. What's all this 0:10:07.120 --> 0:10:12.360 got to do with seag oils. The interesting thing is 0:10:13.000 --> 0:10:17.000 that you might say, Okay, well, that's all fabulous information 0:10:17.040 --> 0:10:19.880 about the CGRPs and how that impacts the brain, and 0:10:19.880 --> 0:10:22.120 it's great that we've got drugs that work on them, 0:10:22.559 --> 0:10:25.280 But what causes the CGRPs to be there in the 0:10:25.280 --> 0:10:29.400 first place is the more interesting question. What causes people 0:10:29.400 --> 0:10:31.840 to have that reaction, what causes them to need a 0:10:31.920 --> 0:10:36.559 drug to counteract them, And that's where some really interesting 0:10:36.640 --> 0:10:39.480 research has been done on what's called oxylipands, which are 0:10:39.520 --> 0:10:45.040 sort of precursors to the CGRPs, and in particular ones 0:10:45.080 --> 0:10:49.960 which are created from amiga six fats. Now amiga six fats, 0:10:50.120 --> 0:10:52.880 you will remember, so we've talked before about seed oils, 0:10:52.920 --> 0:10:58.920 so things like carnola oil, sunflower oil, you know what 0:10:59.080 --> 0:11:02.600 is generally disc as vegetable oil on the label of foods, 0:11:02.679 --> 0:11:04.880 you know, but no vegetables were harmed in the creation. 0:11:05.000 --> 0:11:10.320 They're actually fats that are created from seeds. So there's 0:11:10.400 --> 0:11:16.800 three classes of oil. There's animal fats, there's seed fats, 0:11:17.720 --> 0:11:22.560 and there's oil that you put in your car mineral 0:11:22.600 --> 0:11:29.440 from minerals. So vegetable oils largely created from seeds. Some flowers, aflower, canola, 0:11:29.520 --> 0:11:32.960 et cetera. All of them are very very high in 0:11:33.000 --> 0:11:38.960 AMEGA six polyunsaturated fats. And one of the problems is 0:11:39.040 --> 0:11:44.640 that the rate of growth in migraines, So migraines have 0:11:44.840 --> 0:11:49.120 increased in the population since nineteen ninety, since they started 0:11:49.120 --> 0:11:53.400 counting this sort of thing, by almost sixty percent. So 0:11:53.480 --> 0:11:57.800 since nineteen ninety, the incidence of migraine in the population 0:11:59.160 --> 0:12:05.440 has increased by almost sixty percent. So something's going on 0:12:05.960 --> 0:12:09.800 in the environment. And the interesting thing, and what prompted 0:12:09.840 --> 0:12:12.080 me to write this piece is that I saw I 0:12:12.120 --> 0:12:15.920 came across, just quite by chance, a really excellent piece 0:12:15.960 --> 0:12:20.200 of research. In nutrition science, you rarely see really high 0:12:20.320 --> 0:12:24.320 quality research. It's usually sort of, you know, associative type stuff. 0:12:24.920 --> 0:12:30.240 You know, men who have big cars, you know, have headaches, 0:12:30.480 --> 0:12:32.280 and Tiff was going somewhere else with that one, but 0:12:32.360 --> 0:12:35.400 you know that sort of like associating two things and 0:12:35.440 --> 0:12:38.760 saying these two things correlate, therefore one causes the other. 0:12:39.280 --> 0:12:41.120 That's the kind of research you tend to get in 0:12:41.240 --> 0:12:44.280 nutrition because doing any other kind of research and nutrition 0:12:44.400 --> 0:12:46.199 is really really hard. It's hard to do a double 0:12:46.200 --> 0:12:50.960 blind trial in nutrition because you know, the person knows 0:12:51.000 --> 0:12:53.520 whether they're eating a steak or whether they're eating ice cream, 0:12:54.000 --> 0:12:58.000 so you tend to get mostly rubbish. But there was 0:12:58.040 --> 0:13:05.240 this really really high quality done targeting this question, published 0:13:05.280 --> 0:13:08.920 in the British Medical journal, very good publication. The people 0:13:08.960 --> 0:13:11.560 doing the trial was the National Institute's of Health in 0:13:11.600 --> 0:13:14.080 the United States, in particular a fellow by the name 0:13:14.120 --> 0:13:17.240 of Chris Ramsden who has been assigned as there for 0:13:17.320 --> 0:13:19.960 decades and has been looking at amiga six fats for 0:13:20.000 --> 0:13:23.320 a long time, and he asked the question, is there 0:13:23.360 --> 0:13:26.280 a way we could run a trial to show whether 0:13:26.360 --> 0:13:30.080 or not amiga six fats in some way implicated in 0:13:30.200 --> 0:13:34.480 this massive rise in migraines. And what he did was 0:13:34.559 --> 0:13:38.040 organized exactly that. So he broke a trial group of 0:13:38.080 --> 0:13:43.040 people into three groups. One group ate exactly the way 0:13:43.080 --> 0:13:46.360 they always did, nothing unusual. The second group was asked 0:13:46.400 --> 0:13:49.120 to increase the amount of fish they ate, so therefore 0:13:49.160 --> 0:13:52.319 increased the Amega three in their diet. And the third 0:13:52.360 --> 0:13:57.000 group were asked to do that and swap out all 0:13:57.080 --> 0:14:00.560 the vegetable oils and seed oils in their diet instead 0:14:00.559 --> 0:14:03.280 of using sunflowl oil or canol oils, which olive oil 0:14:03.800 --> 0:14:07.920 or animal fats and intentionally avoid seed oils in the diet. 0:14:07.960 --> 0:14:11.440 And it reduced the amount of Amega six containing fats 0:14:11.440 --> 0:14:14.959 they were consuming by about a third, sorry, so by 0:14:14.960 --> 0:14:17.439 about two thirds. So I dropped them from seven percent 0:14:17.440 --> 0:14:21.240 of calories to two percent of calories. So it was 0:14:21.240 --> 0:14:24.400 a fairly effective trial. It ran for sixteen weeks. All 0:14:24.440 --> 0:14:27.680 of them were pre screened to be migraine sufferers. The 0:14:27.720 --> 0:14:31.080 effects in the group that dropped the Amega six were 0:14:31.160 --> 0:14:35.440 truly massive. Now remember that what I said before about 0:14:35.800 --> 0:14:38.760 the drugs. The most powerful drug that's ever been invented, 0:14:39.080 --> 0:14:43.080 took out two and a half migraine days per month. Yes, 0:14:44.200 --> 0:14:47.360 the group that all they did, they didn't do anything else. 0:14:47.400 --> 0:14:51.720 They just stopped consuming Amega three sorry Amega six fats, 0:14:51.760 --> 0:14:58.680 so stopped consuming seed oils. Four less migraine days per month. 0:14:59.440 --> 0:15:00.960 That's bloody, I mean, no. 0:15:01.000 --> 0:15:05.600 Drugs, nothing. All they did was reduced the amount of 0:15:05.640 --> 0:15:11.400 seed oils they consumed and they got four less days 0:15:11.400 --> 0:15:14.520 per month. Now, I came across this because I happened 0:15:15.000 --> 0:15:17.000 to see it in a story in the New York 0:15:17.040 --> 0:15:21.760 Times about this trial, and the story featured the lady 0:15:21.800 --> 0:15:23.800 that I put in my article, which was. She was 0:15:23.840 --> 0:15:25.680 one of the participants in the trial. This is now 0:15:26.160 --> 0:15:28.360 three years late after the trial. The trial was completed 0:15:28.400 --> 0:15:31.120 in twenty twenty one and published I think in twenty 0:15:31.120 --> 0:15:35.080 twenty two, and she's been doing it ever since. She said, 0:15:35.120 --> 0:15:37.400 there's no way I am going back to eating the 0:15:37.400 --> 0:15:40.200 way I was, because I've been paying free now for 0:15:40.360 --> 0:15:42.640 years and never been paying free my entire life. She's 0:15:42.680 --> 0:15:43.160 fifty eight. 0:15:43.920 --> 0:15:44.240 Wow. 0:15:45.040 --> 0:15:50.640 And this accords with something that I've seen mentioned every 0:15:50.720 --> 0:15:55.400 now and then by people who follow paleo diets. Quite 0:15:55.480 --> 0:15:59.560 by accident. Part of the paleo diet is you tend 0:15:59.640 --> 0:16:04.400 to eat animal fats and avoid seed oils. And a 0:16:04.440 --> 0:16:07.080 lot of people have sort of anecdotally said you see 0:16:07.080 --> 0:16:08.640 it in the chat groups and sign people say, oh, 0:16:08.640 --> 0:16:11.800 I haven't had migraines since I stopped started eating this way. 0:16:12.920 --> 0:16:14.840 You know, has anyone else experience that? And a lot 0:16:14.840 --> 0:16:17.680 of people say, yeah, actually I have, And it accords 0:16:17.720 --> 0:16:21.920 with my own experience from the moment we stopped eating 0:16:21.960 --> 0:16:24.760 seed oils. As a household, my wife has not had 0:16:24.760 --> 0:16:30.760 a migraine, my kids have not had migraines. So that's 0:16:30.800 --> 0:16:31.560 all mabulous. 0:16:31.960 --> 0:16:34.200 How long has that, mate, overwhell. 0:16:35.000 --> 0:16:36.960 I put toxic oil. The book I wrote about this 0:16:37.280 --> 0:16:41.720 out in twenty fourteen, so that's yeah, so that's over 0:16:41.800 --> 0:16:48.200 eleven ten years now and the hang on, no. 0:16:48.320 --> 0:16:50.080 I just I want to ask a couple of questions. 0:16:50.120 --> 0:16:54.360 So sorry, So that's eleven years. That's fucking amazing. On 0:16:54.880 --> 0:16:57.680 how often was your wife having migraines? 0:16:58.280 --> 0:17:00.200 Ah, look, I'd say it to a couple of time. Times 0:17:00.240 --> 0:17:02.560 a month. Would have been a couple of times a month. 0:17:02.720 --> 0:17:05.119 Yeah, so she was having give or take twenty to 0:17:05.160 --> 0:17:09.080 twenty five migraines a year and hasn't had one migraine 0:17:09.280 --> 0:17:16.920 in any year, no sense, that's incredible. And yeah, that's incredible. 0:17:17.640 --> 0:17:20.800 The interesting thing about this is this is the first 0:17:20.800 --> 0:17:25.080 time I've seen real high quality evidence about this. So 0:17:25.440 --> 0:17:27.679 this is one of those things where drug companies have 0:17:27.720 --> 0:17:30.160 been really interested in it because as soon as they 0:17:30.200 --> 0:17:32.199 discovered something you could you know, nail you could hit 0:17:32.240 --> 0:17:35.119 with a hammer, which is the CGRP, they said, well, 0:17:35.520 --> 0:17:38.320 there's a drug target, let's do that. Yes, but they 0:17:38.320 --> 0:17:42.679 stopped there thinking there, Well, this research has done. They said, okay, 0:17:42.720 --> 0:17:46.400 but where's the CGRP come from? And this is where 0:17:46.440 --> 0:17:49.480 they've dug into the mechanism and said, what's really going 0:17:49.520 --> 0:17:53.520 on here is that Amiga six fats, uniquely a Mega 0:17:53.560 --> 0:17:55.119 six fats. These are the only things that can do 0:17:55.160 --> 0:18:02.240 it create a precursor to CGRP prostaglandin or it's a 0:18:02.280 --> 0:18:08.680 class of oxylipins which causes the CGRP to be created. 0:18:10.000 --> 0:18:12.280 And they've said, what if we took the A Mega 0:18:12.280 --> 0:18:15.359 six fats out, what would happen? Their theory was, what 0:18:15.400 --> 0:18:18.720 would happen is it's stopped migraines. Turns out they're right, 0:18:20.480 --> 0:18:24.960 So there is a very simple solution here. Now, as 0:18:25.000 --> 0:18:27.119 with all things about seed oils, there's always going to 0:18:27.119 --> 0:18:30.800 be people to have a propensity for the particular condition 0:18:30.880 --> 0:18:32.840 no matter what, and there'll be people who try this 0:18:32.920 --> 0:18:35.280 and they still get migraines. Maybe not as many, but 0:18:35.320 --> 0:18:39.800 they still get them. But what this shows is that 0:18:39.960 --> 0:18:45.760 the non drug based solution to this is more powerful 0:18:47.280 --> 0:18:51.520 than even the most powerful drug based solution, the miraculous 0:18:51.600 --> 0:18:56.199 one that they've already released. And I just find that fascinating. 0:18:57.520 --> 0:18:59.760 So the full write up, as you say, is in 0:18:59.800 --> 0:19:02.119 that is in that post and people can go and 0:19:02.160 --> 0:19:03.840 look at the read the article if they want to 0:19:04.000 --> 0:19:07.639 read the study if they're interested in that funny? 0:19:07.840 --> 0:19:10.920 Isn't that funny? How? Okay, So you've known this for 0:19:10.960 --> 0:19:12.840 at least eleven years, and I'm sure a lot of 0:19:12.880 --> 0:19:17.199 other people have known it. How I mean, I've been 0:19:17.240 --> 0:19:21.000 in and around health, wellness, fitness, owning gyms, blah blah blah. 0:19:21.119 --> 0:19:25.200 I've never heard of this like this is like, I mean, 0:19:25.280 --> 0:19:27.640 until I saw the article, Like have you ever heard 0:19:27.640 --> 0:19:32.880 of this tip? Like, isn't it funny that there's something 0:19:33.000 --> 0:19:37.800 that's basically twice as good as the best drug? But 0:19:37.840 --> 0:19:41.840 it's not making any one money? Right, So it's not 0:19:42.119 --> 0:19:46.000 it's you know, it doesn't get you know, for whatever reason. 0:19:46.040 --> 0:19:48.000 But it would seem to me there's a correlation there, 0:19:48.000 --> 0:19:50.480 and that's a that's a very inconvenient truth for a 0:19:50.560 --> 0:19:52.760 lot of people who are trying to sell the drug 0:19:52.800 --> 0:19:55.760 that works half as well as removing Mega six oils 0:19:55.760 --> 0:19:56.080 from you. 0:19:56.119 --> 0:20:00.760 But significantly better than any other drug. I mean, you know, 0:20:01.720 --> 0:20:05.040 with good reason. It is put forward as a miracle, 0:20:05.080 --> 0:20:08.159 and it is as far as drug goes. What this 0:20:08.240 --> 0:20:11.320 is study is telling us is, yeah, that's great, but 0:20:11.400 --> 0:20:15.520 we can do even better than that without the drug. Now, 0:20:16.040 --> 0:20:18.760 just before, just before we go on. I just wanted 0:20:18.800 --> 0:20:20.560 to mention the thing I said to Tiff before we 0:20:20.640 --> 0:20:25.960 might talk about the reason why so migrains disproportionately affect women. 0:20:26.480 --> 0:20:29.760 It's the leading cause of disability for women under fifty. 0:20:31.280 --> 0:20:35.400 And the under fifty bit is important there because they're 0:20:35.440 --> 0:20:37.920 the women who are likely to be having periods. And 0:20:38.600 --> 0:20:44.000 we know that estrogen plays a key role in the 0:20:44.040 --> 0:20:49.919 pathway that influences the release of CGRP. So there's particular 0:20:50.000 --> 0:20:54.600 parts of the menstrual cycle and pregnancy and menopause that 0:20:54.800 --> 0:21:02.200 can provide really predictable cycles of vulnerability. So we know that. 0:21:02.280 --> 0:21:04.159 The other interesting thing we know is that men are 0:21:04.160 --> 0:21:05.719 catching up really really fast. 0:21:07.080 --> 0:21:10.240 So is that because men have got more and more 0:21:10.359 --> 0:21:12.000 estrogen and less testosterone? 0:21:12.359 --> 0:21:14.720 No, no, I wish, I wish I could come up 0:21:14.760 --> 0:21:18.320 with you a spectacular acclaim as that for you, Craig, 0:21:18.400 --> 0:21:21.159 But unfortunately it just means that we're now eating so 0:21:21.240 --> 0:21:25.560 much seed oil that it's overwhelming that the limited defense 0:21:25.680 --> 0:21:29.080 is the testosterone play, right, So testosterone waters down the 0:21:29.119 --> 0:21:33.160 effect and we're overcoming that by the amount of seed 0:21:33.160 --> 0:21:34.160 oil that we're consuming. 0:21:35.080 --> 0:21:39.240 Yeah. Yeah, Now, just there's some people who are new 0:21:39.280 --> 0:21:42.200 to you and new to the show and they're going, 0:21:42.280 --> 0:21:44.879 fucking he fuck, this is the best thing I've ever heard, 0:21:45.359 --> 0:21:48.560 because my sister, my son, my daughter, my cousin, my boss, 0:21:48.680 --> 0:21:50.040 my employee needs to know. 0:21:50.119 --> 0:21:50.280 This. 0:21:51.160 --> 0:21:54.920 Just remind everyone what what the seed oils are? 0:21:56.119 --> 0:21:59.560 Oil? Yeah, yeah, Well, basically, if you go onto a 0:21:59.560 --> 0:22:02.320 supermarket and it says vegetable oil on the label, it's 0:22:02.400 --> 0:22:06.439 probably a seed oil. So the seed oils are oils 0:22:06.440 --> 0:22:09.880 that come from seed, so canola seeds, stoy bean, which 0:22:09.920 --> 0:22:19.000 is a legume but let's just go with that, and peanuts, almonds, sunflowers, safflower. 0:22:20.080 --> 0:22:22.240 I think I probably missed one or two, but you 0:22:22.280 --> 0:22:24.960 get the gear, the drift the ones that aren't. So 0:22:25.000 --> 0:22:28.280 there's a couple of vegetables which aren't seed oils, and 0:22:28.320 --> 0:22:31.399 that is olive oil. And so these as a class 0:22:31.400 --> 0:22:33.680 are what I would call fruit oils. So olive is 0:22:33.680 --> 0:22:37.200 a fruit, so is coconut, so coconut oil, olive oil, 0:22:37.359 --> 0:22:40.720 palm oil. Palm is a fruit as well. So those 0:22:40.880 --> 0:22:45.560 three are described as vegetable oils as well, but they 0:22:45.800 --> 0:22:49.320 are generally fine because they're quite low in a Mega 0:22:49.359 --> 0:22:50.240 six m. 0:22:52.160 --> 0:22:54.120 It's funny. The other day I went into the old 0:22:54.160 --> 0:22:57.399 soupy to try and find some of the world famous 0:22:57.440 --> 0:23:02.040 Gillespie good fat I think it's called good fat mayo. 0:23:02.280 --> 0:23:03.120 Is that the one? Yeah? 0:23:03.160 --> 0:23:04.720 Yeah, that's the one. Yeah, yeah, ye know that. 0:23:04.760 --> 0:23:09.280 It's in that short squat yes, round, of course, it's round, 0:23:09.280 --> 0:23:13.080 but it's it's it's like a really relatively small jar 0:23:13.119 --> 0:23:14.240